scholarly journals CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Ruocheng Dong ◽  
Burcu F. Darst ◽  
Yuetiva Deming ◽  
Yue Ma ◽  
Qiongshi Lu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Status

Hippocampal and amygdalar morphological abnormalities in Alzheimer’s disease based on three Chinese MRI datasets

2021 ◽  
Vol 18 ◽  
Author(s):  
Yuanyuan Wei ◽  
Nianwei Huang ◽  
Yong Liu ◽  
Xi Zhang ◽  
Silun Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Shape Analysis ◽  
Early Stage ◽  
Disease Status ◽  
Brain Structures ◽  
Statistical Shape Analysis ◽  
Social Significance ◽  
Statistical Shape ◽  
Shape Characteristics

Background: Early detection of Alzheimer’s disease (AD) and its early stage, the mild cognitive impairment (MCI), has important scientific, clinical and social significance. Magnetic resonance imaging (MRI) based statistical shape analysis provides an opportunity to detect regional structural abnormalities of brain structures caused by AD and MCI. Objective: In this work, we aimed to employ a well-established statistical shape analysis pipeline, in the framework of large deformation diffeomorphic metric mapping, to identify and quantify the regional shape abnormalities of the bilateral hippocampus and amygdala at different prodromal stages of AD, using three Chinese MRI datasets collected from different domestic hospitals. Methods: We analyzed the region-specific shape abnormalities at different stages of the neuropathology of AD by comparing the localized shape characteristics of the bilateral hippocampi and amygdalas between healthy controls and two disease groups (MCI and AD). In addition to group comparison analyses, we also investigated the association between the shape characteristics and the Mini Mental State Examination (MMSE) of each structure of interest in the disease group (MCI and AD combined) as well as the discriminative power of different morphometric biomarkers. Results: We found the strongest disease pathology (regional atrophy) at the subiculum and CA1 subregions of the hippocampus and the basolateral, basomedial as well as centromedial subregions of the amygdala. Furthermore, the shape characteristics of the hippocampal and amygdalar subregions exhibiting the strongest AD related atrophy were found to have the most significant positive associations with the MMSE. Employing the shape deformation marker of the hippocampus or the amygdala for automated MCI or AD detection yielded a significant accuracy boost over the corresponding volume measurement. Conclusion: Our results suggested that the amygdalar and hippocampal morphometrics, especially those of shape morphometrics, can be used as auxiliary indicators for monitoring the disease status of an AD patient.

scholarly journals Neural Correlates of the Impulse Dyscontrol Domain of Mild Behavioral Impairment

2020 ◽  
Author(s):  
Sascha Gill ◽  
Meng Wang ◽  
Pauline Mouches ◽  
Deepthi Rajashekar ◽  
Tolulope Sajobi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Disease Status ◽  
Evidence Base ◽  
Parahippocampal Gyrus ◽  
Radial Diffusivity ◽  
Behavioral Impairment ◽  
Mixed Effect

Abstract Background: Agitation and aggression are common in dementia and pre-dementia. The dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the impulse dyscontrol domain. However, the neural circuitry associated with impulse dyscontrol in neurodegenerative disease is not well understood. The aim of this work is to investigate if regional micro- and macro-structural brain properties are associated with impulse dyscontrol symptoms in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s disease. Methods: Clinical, neuropsychiatric, and T1-weighted and diffusion-tensor MRI (DTI) data from 80 individuals with and 123 individuals without impulse dyscontrol, were obtained from the Alzheimer’s Disease Neuroimaging Initiative. Linear mixed effect (LME) models were used to assess if impulse dyscontrol was related to regional DTI and volumetric parameters. Results: Impulse dyscontrol was present in 17% of participants with NC, 43% with MCI, and 66% with AD. Impulse dyscontrol was associated with: 1) lower fractional anisotropy, and greater mean, axial, and radial diffusivity in the fornix; 2) lesser fractional anisotropy, and greater radial diffusivity in the superior fronto-occipital fasciculus; 3) greater axial diffusivity in the cingulum; 4) grey matter atrophy, specifically, lower cortical thickness and greater surface area in the parahippocampal gyrus. Conclusion: Our findings provide evidence that well-established atrophy patterns of AD are prominent in the presence of impulse dyscontrol, even when disease status is controlled for, and possibly in advance of dementia. Our findings support the growing evidence base for impulse dyscontrol symptoms as an early manifestation of Alzheimer’s disease.

scholarly journals Plasma Biomarkers of Alzheimer’s Disease in African Americans

2021 ◽  
Vol 79 (1) ◽  
pp. 323-334
Author(s):  
Kaancan Deniz ◽  
Charlotte C.G. Ho ◽  
Kimberly G. Malphrus ◽  
Joseph S. Reddy ◽  
Thuy Nguyen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
African Americans ◽  
Plasma Proteins ◽  
Plasma Concentrations ◽  
Disease Status ◽  
Lower Plasma ◽  
Plasma Biomarkers ◽  
Pairwise Correlations ◽  
Inflammatory Proteins

Background/Objective: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer’s disease (AD) pathology and neuroinflammation are associated with disease status in African Americans. Methods: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer’s Disease Studies (FCA3DS). Five plasma proteins reflecting AD neuropathology or inflammation (Aβ42, tau, IL6, IL10, TNFα) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations. Results: Plasma tau levels were higher in AD when adjusted for biological and technical covariates. APOE ɛ4 was associated with lower plasma Aβ42 and tau levels. Older age was associated with higher plasma Aβ42, tau, and TNFα. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with Aβ42. Conclusion: We identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and Aβ42 may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population.

scholarly journals Continuous and risk‐score‐based predictors of ATN Alzheimer's disease status among cognitively healthy individuals: Findings from the EPAD‐LCS study

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Catherine M Calvin ◽  
Casper de Boer ◽  
Vanessa Raymont ◽  
John Gallacher ◽  
Ivan G Koychev ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Score ◽  
Disease Status ◽  
Healthy Individuals

P4-071: CELL-FREE, SINGLE-STRANDED DNA CONCENTRATION IN CSF AS BIOMARKER TO DIAGNOSE ALZHEIMER'S DISEASE STATUS

2006 ◽  
Vol 14 (7S_Part_27) ◽  
pp. P1460-P1461
Author(s):  
Josue D. Gonzalez Murcia ◽  
Lyndsay Staley ◽  
Meganne Ferrel ◽  
Henrik Zetterberg ◽  
John Kauwe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Status ◽  
Single Stranded Dna ◽  
Dna Concentration

Emerging two-dimensional materials-enabled diagnosis and treatments of Alzheimer's disease: Status and future challenges

2021 ◽  
Vol 23 ◽  
pp. 101028
Author(s):  
Shiting Song ◽  
Jingwen Wu ◽  
Ying Cheng ◽  
Lixiang Ma ◽  
Tao Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Status ◽  
Two Dimensional ◽  
Two Dimensional Materials ◽  
Future Challenges
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