Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones

2015 ◽  
Vol 76 (7) ◽  
pp. 799-816 ◽  
Author(s):  
Shruti Jain ◽  
Kristy Welshhans
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Axonal Growth ◽  
Growth Cones ◽  
Local Translation

scholarly journals Translation of the cell adhesion molecule ALCAM in axonal growth cones – regulation and functional importance

2012 ◽  
Vol 125 (4) ◽  
pp. 1003-1014 ◽  
Author(s):  
Karsten Thelen ◽  
Bettina Maier ◽  
Marc Faber ◽  
Christian Albrecht ◽  
Paulina Fischer ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Axonal Growth ◽  
Growth Cones ◽  
Functional Importance

scholarly journals Alternatively spliced down syndrome cell adhesion molecule (Dscam) controls innate immunity in crab

2019 ◽  
Vol 294 (44) ◽  
pp. 16440-16450 ◽  
Author(s):  
Dan Li ◽  
Zhicheng Wan ◽  
Xuejie Li ◽  
Ming Duan ◽  
Lei Yang ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Alternatively Spliced

Herpes virus OsHV-1 and the protistPerkinsus marinusmodify the expression of the Down syndrome cell adhesion molecule gene in gill and mantle ofCrassostreaspp.

2018 ◽  
Vol 49 (11) ◽  
pp. 3638-3646 ◽  
Author(s):  
Lilián Arzeta-Pino ◽  
Armando Acosta ◽  
Maria E. Sarmiento ◽  
Maurilia Rojas-Contreras ◽  
Carmen Rodríguez-Jaramillo ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Herpes Virus ◽  
Adhesion Molecule Gene ◽  
Herpès Virus

scholarly journals Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1

2015 ◽  
Vol 71 (6) ◽  
pp. 775-778 ◽  
Author(s):  
Linna Cheng ◽  
Shu-Ang Li ◽  
Yamei Yu ◽  
Qiang Chen
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Rna Splicing ◽  
Cell Adhesion Molecule ◽  
Crystallographic Analysis ◽  
Homophilic Binding ◽  
Ig Superfamily ◽  
Cell Adhesion Molecule 1 ◽  
Insight Into

Down syndrome cell adhesion molecule 1 (Dscam1), a member of the immunoglobulin (Ig) superfamily, plays important roles in both the nervous and the immune systems. Via alternative RNA splicing,DrosophilaDscam1 encodes a vast family of Ig-containing proteins that exhibit isoform-specific homophilic binding. Whether different Dscam1 isoforms adopt the same dimerization mode is under debate, and the detailed mechanism of Dscam1 specificity remains unclear. In this study, eight different isforms of Dscam1 Ig1–4 have been cloned, overexpressed, purified to homogeneity and crystallized. X-ray data were collected to 1.9–4.0 Å resolution. These structures will provide the opportunity to perform extensive structural comparisons of different Dscam1 isoforms and provide insight into its specificity.

Homophilic synaptic target recognition mediated by immunoglobulin-like cell adhesion molecule Fasciclin III

Development ◽  
1997 ◽  
Vol 124 (20) ◽  
pp. 4143-4152 ◽  
Author(s):  
H. Kose ◽  
D. Rose ◽  
X. Zhu ◽  
A. Chiba
Keyword(s):  
Neural Network ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Growth Cone ◽  
Cell Adhesion Molecule ◽  
Network Formation ◽  
Target Recognition ◽  
Basic Mechanism ◽  
Growth Cones ◽  
Homophilic Interaction

We demonstrate that the cell adhesion molecule Fasciclin III (FAS3) mediates synaptic target recognition through homophilic interaction. FAS3 is expressed by the RP3 motoneuron and its target muscles during synaptic target recognition. The RP3 growth cone can form synapses on muscles that ectopically express FAS3. This mistargeting is dependent on FAS3 expression in the motoneurons. In addition, when the FAS3-negative aCC and SNa motoneuron growth cones ectopically express FAS3, they gain the ability to recognize FAS3-expressing muscles as alternative targets. We propose that homophilic synaptic target recognition serves as a basic mechanism of neural network formation.

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