Testing for AB‐PINACA in human hair: Distribution in head hair versus pubic hair

2019 ◽  
Vol 11 (4) ◽  
pp. 610-616 ◽  
Author(s):  
Nadia Arbouche ◽  
Jean‐Sebastien Raul ◽  
Delphine Garnier ◽  
Pascal Kintz ◽  
Alice Ameline
Keyword(s):  
Human Hair ◽  
Pubic Hair ◽  
Head Hair

scholarly journals Comparative Dispositions of Ofloxacin in Human Head, Axillary, and Pubic Hairs

1998 ◽  
Vol 42 (5) ◽  
pp. 1298-1302 ◽  
Author(s):  
Kazuhiro Kosuge ◽  
Toshihiko Uematsu ◽  
Sei-Ichi Araki ◽  
Hiroyuki Matsuno ◽  
Kyoichi Ohashi ◽  
...  
Keyword(s):  
Growth Rate ◽  
Human Head ◽  
Pubic Hair ◽  
Hair Shaft ◽  
The Other ◽  
Healthy Male ◽  
Head Hair ◽  
Hair Type ◽  
Axillary Hair ◽  
Hair Shafts

ABSTRACT The distribution of ofloxacin (OFLX) along the shaft of each of three hair types, i.e., head, axillary and pubic, was investigated and compared among five healthy male volunteers 1 to 4 months after ingestion of OFLX for 1 or 2 days (total dose, 200 or 600 mg). Five strands of each hair type were sectioned together into successive 0.5-cm lengths starting from the dermal end, over a length of ≤6 cm, and the OFLX concentration in each hair section was measured by high-pressure liquid chromatography with fluorescence detection. The distribution of OFLX along the head hair shaft was narrow, having a single peak even 3 to 4 months after administration, suggesting a rather uniform growth rate among hair strands. On the other hand, the OFLX distribution along axillary or pubic hair shafts tended to be broad, even having two apparent peaks, and the growth rate did not seem uniform. Since axillary hair seemed to stop growing after having gained a length of ≤4 to 5 cm, it was suggested to enter a resting stage after the growth of ≤3 cm over the 2 to 4 months after OFLX incorporation. These findings indicate that head hair is the most suitable for analysis of individual drug use and the larger growth rate and cycle stage variabilities of strands of the other types of hair should be taken into account.

Testing for Stanozolol, Using UPLC–MS-MS and Confirmation by UPLC–q-TOF-MS, in Hair Specimens Collected from Five Different Anatomical Regions

2020 ◽  
Vol 44 (8) ◽  
pp. 834-839
Author(s):  
Laurie Gheddar ◽  
Jean-Sébastien Raul ◽  
Pascal Kintz
Keyword(s):  
Drug Exposure ◽  
Internal Standard ◽  
Anatomical Variations ◽  
Pubic Hair ◽  
Body Hair ◽  
Head Hair ◽  
Alkaline Conditions ◽  
Axillary Hair ◽  
First Time ◽  
Large Distribution

Abstract An athlete challenged the result from an in-competition doping test which returned with an adverse analytical finding for stanozolol, claiming it was due to supplement contamination. Her lawyer asked the laboratory to analyze several hair specimens simultaneously collected from five different anatomical regions, head, arm, leg, pubis and armpit, to document the pattern of drug exposure. A specific UPLC–MS-MS method was developed. After decontamination with dichloromethane, stanozolol was extracted from hair in the presence of stanozolol-d3 used as internal standard, under alkaline conditions, with diethyl ether. Linearity was observed for concentrations ranging from 5 pg/mg to 10 ng/mg. The method has been validated according to linearity, precision and matrix effect. Concentrations of stanozolol in head hair, pubic hair, arm hair, leg hair and axillary hair were 73, 454, 238, 244 and 7,100 pg/mg, respectively. The concentration of stanozolol in head hair is in accordance with data published in the literature. When comparing the concentrations, body hair concentrations were higher than the concentration found in head hair. These results are consistent with a better incorporation rate of stanozolol in body hair when compared to head hair. The simultaneous positive concentrations in different hair types confirm the adverse analytical finding in urine of the top athlete, as the measured concentrations do not support the theory of contamination. For the first time, an anabolic agent was simultaneously tested in hair collected from five different anatomical regions from the same subject, with a large distribution of concentrations, due to anatomical variations, and these findings will help interpretation in further doping cases when documented with hair.

scholarly journals Human infestation with pubic lice

2020 ◽  
Vol 6 (4) ◽  
pp. 567
Author(s):  
Ankush Maheshwary
Keyword(s):  
Human Blood ◽  
Human Hair ◽  
Scalp Hair ◽  
Pubic Hair ◽  
Sexual Contact ◽  
Review Of Literature ◽  
Middle Aged ◽  
Aged Woman ◽  
Middle Aged Woman ◽  
Pediculosis Pubis

Pediculosis pubis is caused by Phthirus pubis (diptera: anoplura) commonly known as crab louse, an obligatory ectoparasite, found on human hair and requires human blood to survive. Pubic lice can be found on pubic hair, underarms, thigh and leg hair, beard and rarely on eyebrows and eyelashes. They are rarely found on scalp hair. Spread of lice occurs mostly by sexual contact but spread via non-sexual contact although rare has also been reported. I present the case of a middle-aged woman with pubic lice. No lice/nits were found in underarm hair, eyebrows or eyelashes. A review of literature is enclosed.

Trace-Element Analysis in Hair: An Evaluation

1974 ◽  
Vol 20 (2) ◽  
pp. 148-151 ◽  
Author(s):  
David C Hilderbrand ◽  
Dari H White
Keyword(s):  
Sample Preparation ◽  
Trace Element ◽  
Human Hair ◽  
Trace Element Analysis ◽  
Pubic Hair ◽  
Cosmetic Products ◽  
Element Analysis ◽  
Hair Samples ◽  
Cu And Zn

Abstract The use of hair as an index to the concentration of certain elements in tissues has been evaluated with regard to the effect of prior cosmetic and sample-washing treatments on the results. Untreated rat-hair samples were subjected to selected grooming or cosmetic products and then washed by various commonly cited sample-preparation procedures. The hair samples were then analyzed for Ca, Mg, Cu, and Zn, and the concentrations found were compared to those in untreated samples. The results indicate that the values observed can be greatly altered by typical treatments given to human hair, and that such changes are not corrected by the commonly used sample-wash procedures. Thus, obtainable samples of human hair, including pubic hair, cannot be expected to indicate accurately the concentration of these metals that would otherwise be present. Other elements should be similarly studied before confidence can be placed in the validity of data for them.

Methadone concentrations in human hair of the head, axillary and pubic hair

1989 ◽  
Vol 102 (5) ◽  
Author(s):  
S. Balabanova ◽  
H.U. Wolf
Keyword(s):  
Human Hair ◽  
Pubic Hair

Ethyl glucuronide: Unusual distribution between head hair and pubic hair

2008 ◽  
Vol 176 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Pascal Kintz ◽  
Marion Villain ◽  
Emilie Vallet ◽  
Mathieu Etter ◽  
Guillaume Salquebre ◽  
...  
Keyword(s):  
Pubic Hair ◽  
Ethyl Glucuronide ◽  
Head Hair ◽  
Unusual Distribution

Pathogenesis of Human Hair Defects

1974 ◽  
Vol 32 ◽  
pp. 12-13
Author(s):  
P.S. Porter ◽  
T. Aoyagi ◽  
R. Matta
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Human Hair ◽  
Standard Techniques ◽  
Scanning Electron

Using standard techniques of scanning electron microscopy (SEM), over 1000 human hair defects have been studied. In several of the defects, the pathogenesis of the abnormality has been clarified using these techniques. It is the purpose of this paper to present several distinct morphologic abnormalities of hair and to discuss their pathogenesis as elucidated through techniques of scanning electron microscopy.

Ruthenium Red Staining of Human Hard Keratin Fibers

1982 ◽  
Vol 40 ◽  
pp. 278-279
Author(s):  
M. C. Buhrer ◽  
R. A. Mathews
Keyword(s):  
Human Hair ◽  
Ruthenium Red ◽  
Acid Mucopolysaccharides ◽  
Biochemical Studies ◽  
Keratin Fibers ◽  
Ruthenium Red Staining ◽  
Extracellular Materials

Ruthenium red has been used as a stain to demonstrate a variety of extracellular materials, especially acid mucopolysaccharides. It also reacts with certain intracellular and extracellular lipids. Since biochemical studies in our laboratory demonstrated the presence of a variety of monosaccharides in human hair ruthenium red staining procedures were adopted in order to evaluate the presence and morphological location of acid oligosaccharides in the keratinized aspect of hair.

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