scholarly journals Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: a post hoc analysis of the SHIFT trial

2017 ◽  
Vol 5 (3) ◽  
pp. 249-256 ◽  
Author(s):  
Edimar Alcides Bocchi ◽  
Salvador Rassi ◽  
Guilherme Veiga Guimarães ◽  
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Safety Profile ◽  
Post Hoc Analysis ◽  
Shift Trial ◽  
Chagas Heart Disease ◽  
Post Hoc

scholarly journals Post hoc analyses of SHIFT and PARADIGM-HF highlight the importance of chronic Chagas' cardiomyopathy Comment on: “Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: a post hoc analysis of the SHIFT trial” by Bocchi et

2018 ◽  
Vol 5 (6) ◽  
pp. 1069-1071 ◽  
Author(s):  
Felix J.A. Ramires ◽  
Felipe Martinez ◽  
Efraín A. Gómez ◽  
Caroline Demacq ◽  
Claudio R. Gimpelewicz ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Safety Profile ◽  
Post Hoc Analysis ◽  
Chagas Cardiomyopathy ◽  
Shift Trial ◽  
Chagas Heart Disease ◽  
Post Hoc

scholarly journals Additive beneficial effects of beta blockers in the prevention of symptomatic heart failure

2016 ◽  
Vol 72 (1) ◽  
Author(s):  
Alberto Genovesi Ebert ◽  
Furio Colivicchi ◽  
Marco Malvezzi Caracciolo ◽  
Carmine Riccio
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Heart Disease ◽  
Beta Blockers ◽  
Structural Heart Disease ◽  
Symptomatic Heart Failure ◽  
Post Hoc Analysis ◽  
Lv Dysfunction ◽  
History Of ◽  
Post Hoc

The prevention of symptomatic heart failure represents the treatment of patients in the A and B stages of AHA/ACC heart failure classification. Stage A refers to patients without structural heart disease but at risk to develop chronic heart failure. The major risk factors in stage A are hypertension, diabetes, atherosclerosis, family history of coronary artery disease and history of cardiotoxic drug use. In this stage, blockers hypertension is the primary area in which beta blockers may be useful. Beta blockers seem not to be superior to other medication in reducing the development of heart failure due to hypertension. Stage B heart failure refers to structural heart disease but without symptoms of heart failure. This includes patients with asymptomatic valvular disease, asymptomatic left ventricular (LV) dysfunction, previous myocardial infarction with or without LV dysfunction. In asymptomatic valvular disease no data are available on the efficacy of beta blockers to prevent heart failure. In asymptomatic LV dysfunction only few asymptomatic patients have been enrolled in the trials which tested beta blockers. NYHA I patients were barely 228 in the MDC, MERIT and ANZ trials altogether. The REVERT trial was the only trial focusing on NYHA I patients with LV ejection fraction less than 40%. Metoprolol extended release on top of ACE inhibitors ameliorated LV systolic volume and ejection fraction. A post hoc analysis of the SOLVD Prevention trial demonstrated that beta blockers reduced death and development of heart failure. Similar results were reported in post MI patients in a post hoc analysis of the SAVE trial (Asymptomatic LV failure post myocardial infarction). In the CAPRICORN trial about 65% of the patients were not taking diuretics and then could be considered asymptomatic. The study revealed a reduction in mortality and a non-significant trend toward reduction of death and hospital admission for heart failure. Conclusions: beta blockers are not specifically indicated in stage A heart failure. On the contrary, in most of the stage B patients, and particularly after MI, beta blockers are indicated to reduce mortality and, probably, also the progression toward symptomatic heart failure.

scholarly journals Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial

2017 ◽  
Vol 5 (5) ◽  
pp. 333-340 ◽  
Author(s):  
Jelena P Seferovic ◽  
Brian Claggett ◽  
Sara B Seidelmann ◽  
Ellen W Seely ◽  
Milton Packer ◽  
...  
Keyword(s):  
Heart Failure ◽  
Glycaemic Control ◽  
Post Hoc Analysis ◽  
Patients With Heart Failure ◽  
Post Hoc

scholarly journals Which statin worked best to achieve lipid level targets in a European registry? A post-hoc analysis of the EUROASPIRE III for coronary heart disease patients

2014 ◽  
Vol 26 (4) ◽  
pp. 183-191 ◽  
Author(s):  
Fahad Alnouri ◽  
David Wood ◽  
Kornelia Kotseva ◽  
Mohamed E.A. Ibrahim
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Level ◽  
Post Hoc Analysis ◽  
Euroaspire Iii ◽  
Post Hoc ◽  
European Registry

scholarly journals Body fat phenotypes and treatment response to spironolactone in ambulatory patients with heart failure and preserved ejection fraction: a post‐hoc analysis of the Aldo‐DHF trial

2020 ◽  
Vol 22 (3) ◽  
pp. 559-561
Author(s):  
Johannes Petutschnigg ◽  
João Pedro Ferreira ◽  
Volker Holzendorf ◽  
Tobias D. Trippel ◽  
Djawid Hashemi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Treatment Response ◽  
Body Fat ◽  
Preserved Ejection Fraction ◽  
Post Hoc Analysis ◽  
Patients With Heart Failure ◽  
Ambulatory Patients ◽  
Post Hoc

scholarly journals The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure

2019 ◽  
Vol 109 (3) ◽  
pp. 331-338 ◽  
Author(s):  
Bernadet T. Santema ◽  
Michelle M. Y. Chan ◽  
Jasper Tromp ◽  
Martin Dokter ◽  
Haye H. van der Wal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Plasma Levels ◽  
Validation Cohort ◽  
Post Hoc Analysis ◽  
Patients With Heart Failure ◽  
History Of ◽  
Post Hoc ◽  
Multivariable Adjustment

Abstract Background In heart failure (HF), levels of NT-proBNP are influenced by the presence of concomitant atrial fibrillation (AF), making it difficult to distinguish between HF versus AF in patients with raised NT-proBNP. It is unknown whether levels of GDF-15 are also influenced by AF in patients with HF. In this study we compared the plasma levels of NT-proBNP versus GDF-15 in patients with HF in AF versus sinus rhythm (SR). Methods In a post hoc analysis of the index cohort of BIOSTAT-CHF (n = 2516), we studied patients with HF categorized into three groups: (1) AF at baseline (n = 733), (2) SR at baseline with a history of AF (n = 183), and (3) SR at baseline and no history of AF (n = 1025). The findings were validated in the validation cohort of BIOSTAT-CHF (n = 1738). Results Plasma NT-proBNP levels of patients who had AF at baseline were higher than those of patients in SR (both with and without a history of AF), even after multivariable adjustment (3417 [25th–75th percentile 1897–6486] versus 1788 [682–3870], adjusted p < 0.001, versus 2231 pg/mL [902–5270], adjusted p < 0.001). In contrast, after adjusting for clinical confounders, the levels of GDF-15 were comparable between the three groups (3179 [2062–5253] versus 2545 [1686–4337], adjusted p = 0.36, versus 2294 [1471–3855] pg/mL, adjusted p = 0.08). Similar patterns of both NT-proBNP and GDF-15 were found in the validation cohort. Conclusion These data show that in patients with HF, NT-proBNP is significantly influenced by underlying AF at time of measurement and not by previous episodes of AF, whereas the levels of GDF-15 are not influenced by the presence of AF. Therefore, GDF-15 might have additive value combined with NT-proBNP in the assessment of patients with HF and concomitant AF. Graphic abstract

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

The Lancet ◽  
2010 ◽  
Vol 376 (9756) ◽  
pp. 1916-1922 ◽  
Author(s):  
Vasilios G Athyros ◽  
Konstantinos Tziomalos ◽  
Thomas D Gossios ◽  
Theodora Griva ◽  
Panagiotis Anagnostis ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Statin Treatment ◽  
Safety And Efficacy ◽  
Post Hoc Analysis ◽  
Post Hoc ◽  
Liver Tests
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