scholarly journals A Novel Approach for Evaluation of Hydrodynamic Model by Integrating Performance for Multiple Variables

2021 ◽  
Author(s):  
Prakat Modi ◽  
Menaka Revel ◽  
Dai Yamazaki
Keyword(s):  
Hydrodynamic Model ◽  
Novel Approach ◽  
Multiple Variables

scholarly journals A Novel Objective Function DYNO for Automatic Multi-variable Calibration and Application to Assess Effects of Velocity versus Temperature Data for 3D Lake Models Calibration

2021 ◽  
Author(s):  
Wei Xia ◽  
Taimoor Akhtar ◽  
Christine A. Shoemaker
Keyword(s):  
Objective Function ◽  
Hydrodynamic Model ◽  
Model Calibration ◽  
Goodness Of Fit ◽  
Optimization Method ◽  
Parallel Optimization ◽  
Velocity Versus ◽  
Observation Data ◽  
Multiple Variables ◽  
Optimization Search

Abstract. This study introduced a novel Dynamically Normalized objective function (DYNO) for multi-variable (i.e., temperature and velocity) model calibration problems. DYNO combines the error metrics of multiple variables into a single objective function by dynamically normalizing each variable's error terms using information available during the search. DYNO is proposed to dynamically adjust the weight of the error of each variable hence balancing the calibration to each variable during optimization search. The DYNO is applied to calibrate a tropical hydrodynamic model where temperature and velocity observation data are used for model calibration simultaneously. We also investigated the efficiency of DYNO by comparing the result of using DYNO to results of calibrating to either temperature or velocity observation only. The result indicates that DYNO can balance the calibration in terms of water temperature and velocity and that calibrating to only one variable (e.g., temperature or velocity) cannot guarantee the goodness-of-fit of another variable (e.g., velocity or temperature). Our study suggested that both temperature and velocity measures should be used for hydrodynamic model calibration in real practice. Our example problems were computed with a parallel optimization method PODS but DYNO can also be easily used in serial applications.

scholarly journals A Novel Approach for Outlier Detection in Multivariate Data

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Saima Afzal ◽  
Ayesha Afzal ◽  
Muhammad Amin ◽  
Sehar Saleem ◽  
Nouman Ali ◽  
...  
Keyword(s):  
Outlier Detection ◽  
Multivariate Data ◽  
Evaluation Criteria ◽  
Real Life ◽  
Simulation Experiments ◽  
Novel Approach ◽  
Multiple Variables ◽  
Components Analysis ◽  
Detection Of Outliers ◽  
F Measure

Outlier detection is a challenging task especially when outliers are defined by rare combinations of multiple variables. In this paper, we develop and evaluate a new method for the detection of outliers in multivariate data that relies on Principal Components Analysis (PCA) and three-sigma limits. The proposed approach employs PCA to effectively perform dimension reduction by regenerating variables, i.e., fitted points from the original observations. The observations lying outside the three-sigma limits are identified as the outliers. This proposed method has been successfully employed to two real life and several artificially generated datasets. The performance of the proposed method is compared with some of the existing methods using different performance evaluation criteria including the percentage of correct classification, precision, recall, and F-measure. The supremacy of the proposed method is confirmed by abovementioned criteria and datasets. The F-measure for the first real life dataset is the highest, i.e., 0.6667 for the proposed method and 0.3333 and 0.4000 for the two existing approaches. Similarly, for the second real dataset, this measure is 0.8000 for the proposed approach and 0.5263 and 0.6315 for the two existing approaches. It is also observed by the simulation experiments that the performance of the proposed approach got better with increasing sample size.

The Need for a Comprehensive Cement Database - A Novel Approach to Best Practices by Cataloging Cement Properties

2021 ◽  
Author(s):  
Jocin James Abraham ◽  
Cameron Devers ◽  
Catalin Teodoriu ◽  
Mahmood Amani
Keyword(s):  
Best Practices ◽  
Best Practice ◽  
Data Entry ◽  
Strength Development ◽  
Optimal Method ◽  
Well Design ◽  
Novel Approach ◽  
Controlled Environments ◽  
Multiple Variables ◽  
Over Time

Abstract In conventional well design, the cement sheath acts as one of the primary barriers of protection in the well integrity matrix. Once the wellbore cement is set, the well is exposed to various conditions and environments over time which can impact the integrity of the cement, the results of which are poorly studied and documented. Given that there are also multiple cement recipes and formulations – the task of studying downhole cement performance and categorizing said results becomes more complicated, requiring the need for an integrated database of information. The objective of this paper is to document desirable cement properties, develop an optimal method for presenting this data, and construct a database which integrates this information and allows streamlined data entry and retrieval. Multiple variables must be considered when aggregating cement recipes and its corresponding properties over time. To test the behavior of these cement recipes over time, samples are created and aged in various controlled environments, and the properties tested periodically. The database was developed with a suitable interface to provide intuitive data entry and practical analysis capability, with proper inputs for the types of cement used, additives added, properties of the cement mixtures over time and any corresponding analysis performed on the samples in order to maximize best practice. Differences in geology, drilling techniques and standards often require the use of different cement recipes with varied additives to cater to each job. These include accelerators, retarders, extenders, weighing agents, fluid and loss control additives, as well as special additives such as latex, fiber additives and foam cements. The database interface is designed to accommodate these variations in the cement recipes and track the properties of samples over time and give a comprehensive understanding of the behavior of the samples as they age. With information from the industry, literature, and laboratory experiments, properties such as the Unconfined Compressive Strength (UCS), thickening times, gel strength development, densities, to name few will be integrated in the data base. Data analytics strategies will also be applied on the information aggregated, and the properties of the samples over time will be correlated to field data as well as literature to ensure proper representation and accuracy of the data. The database and the knowledge collected will be utilized as a source of information to enhance common cementing practices, as well as develop and refine industry best practices, which will be applicable to any cement job in the world. Currently, the database presented in this paper contains over 1000 unique cement samples, prepared and documented by multiple individuals with an aim to create a unique cement repository and database that focuses on long term cement properties.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach

Abusive Men's Use of Children to Control Their Partners and Ex-Partners

2007 ◽  
Vol 12 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Marisa L. Beeble ◽  
Deborah Bybee ◽  
Cris M. Sullivan
Keyword(s):  
United States ◽  
Intimate Partner Violence ◽  
Partner Violence ◽  
Emotional Abuse ◽  
The United States ◽  
Intimate Partner ◽  
Anecdotal Evidence ◽  
Multiple Variables ◽  
The Relationship

While research has found that millions of children in the United States are exposed to their mothers being battered, and that many are themselves abused as well, little is known about the ways in which children are used by abusers to manipulate or harm their mothers. Anecdotal evidence suggests that perpetrators use children in a variety of ways to control and harm women; however, no studies to date have empirically examined the extent of this occurring. Therefore, the current study examined the extent to which survivors of abuse experienced this, as well as the conditions under which it occurred. Interviews were conducted with 156 women who had experienced recent intimate partner violence. Each of these women had at least one child between the ages of 5 and 12. Most women (88%) reported that their assailants had used their children against them in varying ways. Multiple variables were found to be related to this occurring, including the relationship between the assailant and the children, the extent of physical and emotional abuse used by the abuser against the woman, and the assailant's court-ordered visitation status. Findings point toward the complex situational conditions by which assailants use the children of their partners or ex-partners to continue the abuse, and the need for a great deal more research in this area.

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