Impact of sample collection participation on the validity of estimated measures of association in the National Birth Defects Prevention Study when assessing gene-environment interactions

Objective: The primary objective of this study was to evaluate whether there were differences in the characteristics and outcomes of care for children with oral clefts (OCs) among population-based samples in three states. Design: Data on the health status and on speech and esthetic outcomes were collected using structured telephone interviews conducted during 2005–2006 with mothers of children with OCs aged 2 to 7 in Arkansas, Iowa, and New York. Participants: Mothers of children born with nonsyndromic OCs on or after January 1, 1998, and on or before December 31, 2003, in Arkansas, Iowa, or New York. Subjects were identified through their participation in the ongoing National Birth Defects Prevention Study. Main Outcome Measures: Demographic characteristics, rating of cleft care, severity of condition, health status, esthetic outcomes, and speech problems were evaluated by state of residence. Results: Children with OCs from Arkansas were from lower income families, and their parents were less likely to be married. Children with OCs from Arkansas were more likely to have special health care needs and to require mental health care. Few differences were found across states in type of cleft, severity of cleft, or outcomes of cleft care. Conclusions: Combining results from population-based samples across multiple studies increases the variability of sample characteristics. Including multiple states can be an efficient way to learn more about the outcomes of medical care for less common conditions such as oral cleft.

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Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011

The Journal of Pediatrics ◽

10.1016/j.jpeds.2021.09.005 ◽

2021 ◽

Author(s):

Elijah H. Bolin ◽

Yevgeniya Gokun ◽

Paul A. Romitti ◽

Sarah C. Tinker ◽

April D. Summers ◽

...

Keyword(s):

Birth Defects ◽

Congenital Heart Defects ◽

Maternal Smoking ◽

Congenital Heart ◽

Heart Defects ◽

Prevention Study

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Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997–2011

Occupational and Environmental Medicine ◽

10.1136/oemed-2021-107561 ◽

2021 ◽

pp. oemed-2021-107561

Author(s):

Miriam R Siegel ◽

Carissa M Rocheleau ◽

Kendra Broadwater ◽

Albeliz Santiago-Colón ◽

Candice Y Johnson ◽

...

Keyword(s):

Birth Defects ◽

Cleft Lip ◽

Population Based ◽

Small Samples ◽

Prevention Study ◽

Control Data ◽

Reproductive Effects ◽

Race Ethnicity ◽

Maternal Occupation ◽

Pregnancy And Birth

ObjectiveNail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investigated associations between selected birth defects and maternal occupation as a nail technician or hairdresser versus a non-cosmetology occupation during pregnancy.MethodsWe analysed population-based case–control data from the multisite National Birth Defects Prevention Study, 1997–2011. Cases were fetuses or infants with major structural birth defects; controls were live-born infants without major birth defects. Expert raters classified self-reported maternal jobs as nail technician, combination nail technician-hairdresser, hairdresser, other cosmetology work or non-cosmetology work. We used logistic regression to calculate adjusted ORs and 95% CIs for associations between occupation during pregnancy and birth defects, controlling for age, smoking, education and race/ethnicity.ResultsSixty-one mothers worked as nail technicians, 196 as hairdressers, 39 as combination nail technician-hairdressers and 42 810 as non-cosmetologists. The strongest associations among nail technicians included seven congenital heart defect (CHD) groups (ORs ranging from 2.7 to 3.5) and neural tube defects (OR=2.6, CI=0.8 to 8.4). Birth defects most strongly associated with hairdressing included anotia/microtia (OR=2.1, CI=0.6 to 6.9) and cleft lip with cleft palate (OR=2.0, CI=1.1 to 3.7). All oral cleft groups were associated with combination nail technician-hairdresser work (ORs ranging from 4.2 to 5.3).ConclusionsSmall samples resulted in wide CIs. Still, results suggest associations between maternal nail technician work during pregnancy and CHDs and between hairdressing work and oral clefts.

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Fish consumption prior to pregnancy and pregnancy outcomes in the National Birth Defects Prevention Study, 1997–2011

Public Health Nutrition ◽

10.1017/s1368980018002641 ◽

2018 ◽

Vol 22 (2) ◽

pp. 336-343

Author(s):

Renata H Benjamin ◽

Laura E Mitchell ◽

Mark A Canfield ◽

Adrienne T Hoyt ◽

Dejian Lai ◽

...

Keyword(s):

Preterm Birth ◽

Birth Defects ◽

Pregnancy Outcomes ◽

Fish Consumption ◽

Large Population ◽

Population Based ◽

Prevention Study ◽

Preparation Methods ◽

The Usa ◽

Early Preterm Birth

AbstractObjectiveTo evaluate the relationships between maternal fish consumption and pregnancy outcomes in a large, population-based sample of women in the USA.DesignWe collected average fish consumption prior to pregnancy using a modified version of the semi-quantitative Willett FFQ. We estimated adjusted OR (aOR) and 95 % CI for associations between different levels of fish consumption and preterm birth (<37 weeks), early preterm birth (<32 and <35 weeks) and small-for-gestational-age infants (SGA; <10th percentile).SettingThe National Birth Defects Prevention Study (NBDPS).SubjectsControl mother–infant pairs with estimated delivery dates between 1997 and 2011 (n 10 919).ResultsNo significant associations were observed between fish consumption and preterm birth or early preterm birth (aOR = 0·7–1·0 and 0·7–0·9, respectively). The odds of having an SGA infant were elevated (aOR = 2·1; 95 % CI 1·2, 3·4) among women with daily fish consumption compared with women consuming fish less than once per month. No associations were observed between other levels of fish consumption and SGA (aOR = 0·8–1·0).ConclusionsHigh intake of fish was associated with twofold higher odds of having an SGA infant, while moderate fish consumption prior to pregnancy was not associated with preterm or SGA. Our study, like many other studies in this area, lacked information regarding preparation methods and the specific types of fish consumed. Future studies should incorporate information on nutrient and contaminant contents, preparation methods and biomarkers to assess these relationships.

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Impact of Time to Maternal Interview on Interview Responses in the National Birth Defects Prevention Study

American Journal of Epidemiology ◽

10.1093/aje/kws352 ◽

2013 ◽

Vol 177 (11) ◽

pp. 1225-1235 ◽

Cited By ~ 14

Author(s):

S. C. Tinker ◽

C. Gibbs ◽

M. J. Strickland ◽

O. J. Devine ◽

K. S. Crider ◽

...

Keyword(s):

Birth Defects ◽

Prevention Study

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Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study

Birth Defects Research ◽

10.1002/bdr2.1664 ◽

2020 ◽

Vol 112 (6) ◽

pp. 503-514 ◽

Cited By ~ 1

Author(s):

Kristin J. Moore ◽

Suzan L. Carmichael ◽

Nina E. Forestieri ◽

Tania A. Desrosiers ◽

Robert E. Meyer ◽

...

Keyword(s):

Risk Factor ◽

Birth Defects ◽

Maternal Diet ◽

Anterior Segment ◽

Congenital Glaucoma ◽

Prevention Study ◽

Primary Congenital Glaucoma

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Maternal report of fever from cold or flu during early pregnancy and the risk for noncardiac birth defects, National Birth Defects Prevention Study, 1997-2011

Birth Defects Research ◽

10.1002/bdr2.1147 ◽

2017 ◽

Vol 110 (4) ◽

pp. 342-351 ◽

Cited By ~ 13

Author(s):

Dorothy Kim Waller ◽

Syed Shahrukh Hashmi ◽

Adrienne T. Hoyt ◽

Hao T. Duong ◽

Sarah C. Tinker ◽

...

Keyword(s):

Birth Defects ◽

Early Pregnancy ◽

Prevention Study ◽

Maternal Report

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Maternal occupational exposure to solvents and gastroschisis in offspring - National Birth Defects Prevention Study 1997–2011

Occupational and Environmental Medicine ◽

10.1136/oemed-2019-106147 ◽

2020 ◽

Vol 77 (3) ◽

pp. 172-178 ◽

Cited By ~ 1

Author(s):

Nynke Spinder ◽

Lynn M Almli ◽

Tania A Desrosiers ◽

Kathryn E Arnold ◽

Jorieke E H Bergman ◽

...

Keyword(s):

Occupational Exposure ◽

Birth Defects ◽

Maternal Age ◽

Large Population ◽

First Trimester ◽

Population Based ◽

Cumulative Exposure ◽

Surveillance Systems ◽

Prevention Study ◽

Solvent Exposure

ObjectivesThe aim of this study was to assess the association between maternal occupational exposure to solvents and gastroschisis in offspring.MethodsWe used data from the National Birth Defects Prevention Study, a large population-based case-control study of major birth defects conducted in 10 US states from 1997 to 2011. Infants with gastroschisis were ascertained by active birth defects surveillance systems. Control infants without major birth defects were selected from vital records or birth hospital records. Self-reported maternal occupational histories were collected by telephone interview. Industrial hygienists reviewed this information to estimate exposure to aromatic, chlorinated and petroleum-based solvents from 1 month before conception through the first trimester of pregnancy. Cumulative exposure to solvents was estimated for the same period accounting for estimated exposure intensity and frequency, job duration and hours worked per week. ORs and 95% CIs were estimated to assess the association between exposure to any solvents or solvent classes, and gastroschisis risk.ResultsAmong 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively. Exposure to any solvent versus no exposure to solvents was not associated with gastroschisis after adjusting for maternal age (OR 1.00, 95% CI 0.75 to 1.32), nor was an association noted for solvent classes. There was no exposure-response relationship between estimated cumulative solvent exposure and gastroschisis after adjusting for maternal age.ConclusionOur study found no association between maternal occupational solvent exposure and gastroschisis in offspring. Further research is needed to understand risk factors for gastroschisis.

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