The longitudinal associations between C-reactive protein and depressive symptoms: evidence from the English Longitudinal Study of Ageing (ELSA)

2014 ◽  
Vol 30 (9) ◽  
pp. 976-984 ◽  
Author(s):  
Bonnie Au ◽  
Kimberley J. Smith ◽  
Geneviève Gariépy ◽  
Norbert Schmitz
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Longitudinal Associations ◽  
English Longitudinal Study

scholarly journals Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging

2018 ◽  
Vol 74 (2) ◽  
pp. 195-203 ◽  
Author(s):  
Camille Lassale ◽  
G David Batty ◽  
Andrew Steptoe ◽  
Dorina Cadar ◽  
Tasnime N Akbaraly ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Healthy Aging ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
English Longitudinal Study

scholarly journals Does a poor childhood associate with higher and steeper inflammation trajectories in the English Longitudinal Study of Ageing?

2018 ◽  
Author(s):  
Gindo Tampubolon ◽  
Maria Fajarini
Keyword(s):  
Longitudinal Study ◽  
Child Poverty ◽  
Later Life ◽  
C Reactive Protein ◽  
Childhood Poverty ◽  
Reactive Protein ◽  
The Past ◽  
History Information ◽  
English Longitudinal Study ◽  
Childhood Condition

ABSTRACTInflammation has been implicated in many diseases in later life of older Britons. Moreover, health outcomes in later life have also been markedly affected by childhood poverty. But no study has established whether childhood poverty has the effect of upregulating inflammation throughout later life. Using the English Longitudinal Study of Ageing (2004 – 2013) life history information and longitudinal observations of C-reactive protein and fibrinogen as inflammatory biomarkers, we studied the association between childhood condition and trajectories of inflammation for people aged 50 to 97 years. Retrospective childhood poverty some four to eight decades in the past was treated as a latent construct; attrition in longitudinal observations is addressed using inverse proportional to attrition weighting. The analytis revealed significantly higher levels of both biomarkers throughout later life among those with a poor childhood, though there is no evidence of a steeper inflammation trajectory among them. We discussed possible epigenetic changes underlying this strong and long arm of childhood condition. The results suggest that eliminating child poverty can prove to be a wise investment with the prospect of a lifelong reward.

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