The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study

2015 ◽  
Vol 31 (3) ◽  
pp. 231-239 ◽  
Author(s):  
Rui-rui Yang ◽  
Bo-cheng Lu ◽  
Tao Li ◽  
Yi-feng Du ◽  
Xiang Wang ◽  
...  
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Post Stroke ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Post Stroke Depression ◽  
The Relationship

scholarly journals A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sarah Tan Siyin ◽  
Tong Liu ◽  
Wenqiang Li ◽  
Nan Yao ◽  
Guoshuai Xu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Regression Models ◽  
Primary Liver Cancer ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship ◽  
New Onset

Abstract Background Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC). Our study aims to prospectively investigate the relationship between hs-CRP and new-onset PLC. Methods and results Ninety-five thousand seven hundred fifty-nine participants without the diagnosis of PLC, and who had their demographic characteristics and biochemical parameters recorded, were analyzed from the Kailuan Cohort study. Cox proportional hazards regression models and competing risk regression models were used to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of PLC. During a median follow-up of 11.07 years, 357 incidental PLC cases were identified over a total of 1,035,039 person-years. The multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.07(0.82 ~ 1.38), 1.51(1.15 ~ 1.98) in a Cox proportional hazard regression analysis adjusted for other potential confounders. In the cause-specific hazard model, the multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.06(0.81 ~ 1.40), 1.50(1.14 ~ 1.99). Similar results were also observed in the sub-distribution hazard function model with corresponding multivariate HRs (95%CI) of 1.05(0.80 ~ 1.40), 1.49(1.13 ~ 1.98) in hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L group, respectively. Conclusions This prospective study found a significant association of higher levels of hs-CRP with new-onset PLC. The main clinical implications would be an increased awareness of hs-CRP and its correlation to the risk of PLC. This study should be a steppingstone to further research on chronic inflammation and PLC. Trial registration Registration number:ChiCTR–TNRC–11001489.

The prognostic value of high-sensitivity C-reactive protein blood level after coronary stenting for the development of stent restenosis

Kardiologiia ◽  
2020 ◽  
Vol 60 (7) ◽  
pp. 64-71
Author(s):  
A. Yu. Filatova ◽  
G. V. Shlevkova ◽  
A. V. Potekhina ◽  
A. K. Osokina ◽  
E. A. Noeva ◽  
...  
Keyword(s):  
Roc Curve ◽  
Roc Analysis ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Stent Restenosis ◽  
Neointimal Proliferation ◽  
Exertional Angina ◽  
The Relationship

Aim      To analyze the relationship between serum concentrations of high-sensitivity C-reactive protein (hsCRP) in dynamics and development of restenosis at 12 months following elective coronary stent placement (CSP).Material and methods  The key role in atherogenesis, neointimal proliferation and restenosis belongs to inflammation. This study included 91 patients (median age, 60 [56; 66] years) with stable exertional angina after an elective CSP using second-generation stents. Follow-up coronarography was performed for 60 patients at 12 months. Concentration of hsCRP was measured immediately prior to CSP and at 1, 3, 6, and 12 months after CSP. Restenosis of the stented segment (50% or more narrowing of the stented segment or a 5-mm vessel segment proximally or distally adjacent to the stented segment) was observed in 8 patients.Results According to results of the ROC analysis, the increase in hsCRP concentration >0.9 mg/l (>25%) at one month after CSP had the highest predictive significance with respect of restenosis (area under the ROC curve, 0.89 at 95 % confidence interval (CI) from 0.79 to 0.99; sensitivity, 87.5 %; specificity, 82.8 %; р=0.0005), which was superior to the absolute value of hsCRP concentration >3.0 mg/l (area under the ROC curve, 0.82 at 95 % CI from 0.68 to 0.96; р=0.0007).Conclusion      Increased concentration of hsCRP ≥0.9 mg /l (≥25 %) at a month after CSP was associated with restenosis of the coronary artery stented segment.

Combination of High-Sensitivity C-Reactive Protein and Homocysteine Predicts the Post-Stroke Depression in Patients with Ischemic Stroke

2017 ◽  
Vol 55 (4) ◽  
pp. 2952-2958 ◽  
Author(s):  
Li-Shan Cheng ◽  
Wen-Jun Tu ◽  
Yuan Shen ◽  
Li-Jun Zhang ◽  
Kangxiang Ji
Keyword(s):  
Ischemic Stroke ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Post Stroke ◽  
Reactive Protein ◽  
Post Stroke Depression

scholarly journals The co-existence of elevated high sensitivity C-reactive protein and homocysteine levels is associated with increased risk of metabolic syndrome: A 6-year follow-up study

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0206157 ◽  
Author(s):  
Jinkwan Kim ◽  
Sangshin Pyo ◽  
Dae Wui Yoon ◽  
Seungkwan Lee ◽  
Ja-Yun Lim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Increased Risk
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