scholarly journals The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis

2020 ◽  
Author(s):  
Lars Costers ◽  
Jeroen Van Schependom ◽  
Jorne Laton ◽  
Johan Baijot ◽  
Martin Sjøgård ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Working Memory ◽  
Memory Impairment ◽  
Theta Oscillations ◽  
Hippocampal Theta

Cognition in Early Relapsing-Remitting Multiple Sclerosis: Consequences May Be Relative to Working Memory

2013 ◽  
Vol 19 (8) ◽  
pp. 938-949 ◽  
Author(s):  
Lindsay I. Berrigan ◽  
Jo-Anne LeFevre ◽  
Laura M. Rees ◽  
Jason Berard ◽  
Mark S. Freedman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Working Memory ◽  
Processing Speed ◽  
Cognitive Functions ◽  
Group Membership ◽  
Equation Modeling ◽  
Mediating Role ◽  
Relapsing Remitting ◽  
Disease Stages

AbstractThe Relative Consequence Model proposes multiple sclerosis (MS) patients have a fundamental deficit in processing speed that compromises other cognitive functions. The present study examined the mediating role of processing speed, as well as working memory, in the MS-related effects on other cognitive functions for early relapsing-remitting patients. Seventy relapsing-remitting MS patients with disease duration not greater than 10 years and 72 controls completed tasks assessing processing speed, working memory, learning, and executive functioning. The possible mediating roles of speed and working memory in the MS-related effects on other cognitive functions were evaluated using structural equation modeling. Processing speed was not significantly related to group membership and could not have a mediating role. Working memory was related to group membership and functioned as a mediating/intervening factor. The results do not support the Relative Consequence Model in this sample and they challenge the notion that working memory impairment only emerges at later disease stages. The results do support a mediating/intervening role of working memory. These results were obtained for early relapsing-remitting MS patients and should not be generalized to the broader MS population. Instead, future research should examine the relations that exist at other disease stages. (JINS, 2013, 19, 1–12)

Theta power and theta-gamma coupling support spatial memory retrieval

2019 ◽  
Author(s):  
Umesh Vivekananda ◽  
Daniel Bush ◽  
James A Bisby ◽  
Sallie Baxendale ◽  
Roman Rodionov ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Task Performance ◽  
Memory Function ◽  
Memory Task ◽  
Theta Oscillations ◽  
Theta Power ◽  
Human Epilepsy ◽  
Phase Amplitude ◽  
Hippocampal Theta

AbstractHippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations during spatial memory function, and how this relates to subsequent behaviour. Here we asked ten human epilepsy patients undergoing intracranial EEG recording to perform a desk-top virtual reality spatial memory task, and found that increased theta power in two discrete bands (‘low’ 2-5Hz and ‘high’ 6-9Hz) during cued retrieval was associated with improved task performance. Similarly, increased coupling between ‘low’ theta phase and gamma amplitude during the same period was associated with improved task performance. These results support a role of theta oscillations and theta-gamma phase-amplitude coupling in human spatial memory function.

scholarly journals Hippocampal Stimulation of Fornical-lesioned Rats Improves Working Memory

1994 ◽  
Vol 21 (2) ◽  
pp. 100-103 ◽  
Author(s):  
J. Turnbull ◽  
F. Jiang ◽  
R. Racine
Keyword(s):  
Working Memory ◽  
Memory Impairment ◽  
Theta Rhythm ◽  
Rhythmic Activity ◽  
Hippocampal Theta Rhythm ◽  
Disease States ◽  
Hippocampal Stimulation ◽  
Hippocampal Theta ◽  
The Brain ◽  
Normal Cognition

Abstract:Intrinsic rhythmic electrical activity in the brain, such as the hippocampal theta rhythm, might serve important roles in normal cognition. Lesions to the medial septal nuclei, or to the fimbria/fornix, disrupt the hippocampal theta rhythm and lead to memory impairment. We have superimposed an artifical stimulating rhythm to the hippocampus of rats with prior lesion of the fornix, during testing in the Morris water maze. This intervention improves performance in a test of working memory, and lends support to the view that intrinsic rhythmic activity may play an important role in normal physiology, and in certain disease states.

scholarly journals The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis

2020 ◽  
Author(s):  
Lars Costers ◽  
Jeroen Van Schependom ◽  
Jorne Laton ◽  
Johan Baijot ◽  
Martin Sjøgård ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Working Memory ◽  
Healthy Subjects ◽  
Neuronal Damage ◽  
Hippocampal Damage ◽  
Theta Power ◽  
Power Increase ◽  
Neurophysiological Mechanisms ◽  
The Right ◽  
Hippocampal Theta

AbstractWorking memory (WM) problems are frequent in persons with multiple sclerosis (MS). Even though hippocampal damage has been repeatedly shown to play an important role, the underlying neurophysiological mechanisms remain unclear. This study aimed to investigate the neurophysiological underpinnings of WM impairment in MS using magnetoencephalography (MEG) data from a verbal n-back task. We analysed MEG recordings of 79 MS patients and 38 healthy subjects through event-related fields (ERFs) and theta (4-8 Hz) and alpha (8-13 Hz) oscillatory processes. Data was source reconstructed and parcellated based on previous findings in the healthy subject sample. MS patients showed a smaller maximum theta power increase in the right hippocampus between 0 and 400 ms than healthy subjects (p = 0.014). This theta power increase value correlated strongly and negatively with reaction time on the task in MS (r = −0.32, p = 0.029). Evidence was provided that this relationship could not be explained by a confounding relationship with MS-related neuronal damage. This study provides the first neurophysiological evidence of the influence of hippocampal dysfunction on WM performance in MS.

scholarly journals Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

2017 ◽  
Vol 17 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Tristan Shuman ◽  
Benjamin Amendolara ◽  
Peyman Golshani
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Large Scale ◽  
Theta Oscillations ◽  
Cognitive Disability ◽  
Future Directions ◽  
Significant Disability ◽  
Memory Disturbance ◽  
Hippocampal Theta

Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.

scholarly journals Working memory impairment in multiple sclerosis relapsing-remitting patients with episodic memory deficits

2010 ◽  
Vol 68 (2) ◽  
pp. 205-211 ◽  
Author(s):  
Simone Freitas Fuso ◽  
Dagoberto Callegaro ◽  
Sabine Pompéia ◽  
Orlando F.A. Bueno
Keyword(s):  
Multiple Sclerosis ◽  
Working Memory ◽  
Episodic Memory ◽  
Memory Impairment ◽  
Memory Deficits ◽  
Healthy Controls ◽  
Relapsing Remitting

Episodic memory is impaired in multiple sclerosis (MS) patients, possibly because of deficits in working memory (WM) functioning. If so, WM alterations should necessarily be found in patients with episodic memory deficits, but this has not yet been demonstrated. In this study we aimed at determining whether episodic memory deficits in relapsing-remitting MS are found in conjunction with impaired WM. We evaluated 32 MS patients and 32 matched healthy controls. Nineteen of the 32 patients had episodic memory impairment, and as a group only these individuals showed deficits in WM capacity, which may lead to difficulty in encoding, and/or retrieving information from episodic memory.

Measurement and Modulation of Working Memory-Related Oscillatory Abnormalities

2019 ◽  
Vol 25 (10) ◽  
pp. 1076-1081
Author(s):  
Brian C. Kavanaugh ◽  
Alexa Fryc ◽  
Linda L. Carpenter
Keyword(s):  
Working Memory ◽  
Test Performance ◽  
Clinical Symptoms ◽  
Critical Role ◽  
Theta Oscillations ◽  
Clinical Neuropsychology ◽  
Targeted Interventions ◽  
Neural Underpinnings ◽  
Neuropsychiatric Conditions

AbstractDespite the critical role of working memory (WM) in neuropsychiatric conditions, there remains a dearth of available WM-targeted interventions. Gamma and theta oscillations as measured with electroencephalography (EEG) or magnetoencephalography (MEG) reflect the neural underpinnings of WM. The WM processes that fluctuate in conjunction with WM demands are closely correlated with WM test performance, and their EEG signatures are abnormal in several clinical populations. Novel interventions such as transcranial magnetic stimulation (TMS) have been shown to modulate these oscillations and subsequently improve WM performance and clinical symptoms. Systematically identifying pathological WM-related gamma/theta oscillatory patterns with EEG/MEG and developing ways to target them with interventions such as TMS is an active area of clinical research. Results hold promise for enhancing the outcomes of our patients with WM deficits and for moving the field of clinical neuropsychology towards a mechanism-based approach.

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