scholarly journals Genome-level analysis of genetic regulation of liver gene expression networks

Hepatology ◽  
2007 ◽  
Vol 46 (2) ◽  
pp. 548-557 ◽  
Author(s):  
Daniel Gatti ◽  
Akira Maki ◽  
Elissa J. Chesler ◽  
Roumyana Kirova ◽  
Oksana Kosyk ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genetic Regulation ◽  
Liver Gene ◽  
Genome Level ◽  
Level Analysis

Gene Expression Level Analysis

2020 ◽  
Author(s):  
Keyword(s):  
Gene Expression ◽  
Gene Expression Level ◽  
Expression Level ◽  
Level Analysis

Dynamic Changes in the Regulation of Energy Balance after Roux-en-Y Gastric Bypass Are Reflected in Time-Dependent Alterations in Liver Gene Expression

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 289-LB
Author(s):  
M. AGOSTINA SANTORO ◽  
JOSEPH BRANCALE ◽  
JILL CARMODY GARRISON ◽  
SRIRAM MACHINENI ◽  
SCOTT A. LAJOIE ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Bypass ◽  
Energy Balance ◽  
Time Dependent ◽  
Dynamic Changes ◽  
Liver Gene

Extensive changes in liver gene expression induced by Hereditary Tyrosinemia type I are not normalized by treatment with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC)

2003 ◽  
Vol 39 (6) ◽  
pp. 901-909 ◽  
Author(s):  
Marjanka C Luijerink ◽  
Saskia M.M Jacobs ◽  
Ellen A.C.M van Beurden ◽  
Leander P Koornneef ◽  
Leo W.J Klomp ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type I ◽  
Tyrosinemia Type I ◽  
Liver Gene ◽  
Hereditary Tyrosinemia

Liver Gene Expression Signature of Mild Fibrosis in Patients With Chronic Hepatitis C

2005 ◽  
Vol 129 (6) ◽  
pp. 2064-2075 ◽  
Author(s):  
Tarik Asselah ◽  
Ivan Bièche ◽  
Ingrid Laurendeau ◽  
Valérie Paradis ◽  
Dominique Vidaud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Liver Gene

scholarly journals Context-dependent expression of the foraging gene in field colonies of ants: the interacting roles of age, environment and task

2016 ◽  
Vol 283 (1837) ◽  
pp. 20160841 ◽  
Author(s):  
Krista K. Ingram ◽  
Deborah M. Gordon ◽  
Daniel A. Friedman ◽  
Michael Greene ◽  
John Kahler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Task Allocation ◽  
Molecular Mechanisms ◽  
Light Exposure ◽  
Genetic Regulation ◽  
Behavioural Plasticity ◽  
Harvester Ants ◽  
Ontogenetic Changes ◽  
Context Dependent ◽  
And Task

Task allocation among social insect workers is an ideal framework for studying the molecular mechanisms underlying behavioural plasticity because workers of similar genotype adopt different behavioural phenotypes. Elegant laboratory studies have pioneered this effort, but field studies involving the genetic regulation of task allocation are rare. Here, we investigate the expression of the foraging gene in harvester ant workers from five age- and task-related groups in a natural population, and we experimentally test how exposure to light affects foraging expression in brood workers and foragers. Results from our field study show that the regulation of the foraging gene in harvester ants occurs at two time scales: levels of foraging mRNA are associated with ontogenetic changes over weeks in worker age, location and task, and there are significant daily oscillations in foraging expression in foragers. The temporal dissection of foraging expression reveals that gene expression changes in foragers occur across a scale of hours and the level of expression is predicted by activity rhythms: foragers have high levels of foraging mRNA during daylight hours when they are most active outside the nests. In the experimental study, we find complex interactions in foraging expression between task behaviour and light exposure. Oscillations occur in foragers following experimental exposure to 13 L : 11 D (LD) conditions, but not in brood workers under similar conditions. No significant differences were seen in foraging expression over time in either task in 24 h dark (DD) conditions. Interestingly, the expression of foraging in both undisturbed field and experimentally treated foragers is also significantly correlated with the expression of the circadian clock gene, cycle . Our results provide evidence that the regulation of this gene is context-dependent and associated with both ontogenetic and daily behavioural plasticity in field colonies of harvester ants. Our results underscore the importance of assaying temporal patterns in behavioural gene expression and suggest that gene regulation is an integral mechanism associated with behavioural plasticity in harvester ants.

scholarly journals Potential of processed animal protein versus soybean meal to replace fish meal in practical diets for European catfish (Silurus glanis): growth response and liver gene expression

2017 ◽  
Vol 23 (5) ◽  
pp. 1179-1189 ◽  
Author(s):  
S. Kumar ◽  
J. Sándor Zs ◽  
Z. Nagy ◽  
G. Fazekas ◽  
M. Havasi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Soybean Meal ◽  
Growth Response ◽  
Fish Meal ◽  
Animal Protein ◽  
Silurus Glanis ◽  
European Catfish ◽  
Liver Gene ◽  
Protein Versus

scholarly journals Sexual Dimorphism of Rat Liver Gene Expression: Regulatory Role of Growth Hormone Revealed by Deoxyribonucleic Acid Microarray Analysis

2004 ◽  
Vol 18 (3) ◽  
pp. 747-760 ◽  
Author(s):  
Amrita Ahluwalia ◽  
Karl H. Clodfelter ◽  
David J. Waxman
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Sexual Dimorphism ◽  
Microarray Analysis ◽  
Rat Liver ◽  
Deoxyribonucleic Acid ◽  
Regulatory Role ◽  
Liver Gene

scholarly journals Targeted Analysis of Three Hormonal Systems Identifies Molecules Associated with the Presence and Severity of NAFLD

2019 ◽  
Vol 105 (3) ◽  
pp. e390-e400 ◽  
Author(s):  
Stergios A Polyzos ◽  
Nikolaos Perakakis ◽  
Chrysoula Boutari ◽  
Jannis Kountouras ◽  
Wael Ghaly ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Fibrosis ◽  
Therapeutic Targets ◽  
Diagnostic Markers ◽  
Oral Glucose ◽  
Simple Steatosis ◽  
Early Stages ◽  
Liver Gene ◽  
Circulating Levels ◽  
Igfbp 3

Abstract Aims To investigate circulating levels and liver gene expression of 3 hormonal pathways associated with obesity, insulin resistance, and inflammation to identify leads towards potential diagnostic markers and therapeutic targets in patients with nonalcoholic fatty liver disease (NAFLD). Methods We compared circulating levels of (1) proglucagon-derived hormones (glucagon-like peptide [GLP]-1, GLP-2, glicentin, oxyntomodulin, glucagon, major proglucagon fragment [MPGF]), (2) follistatins-activins (follistatin-like [FSTL]3, activin B), (3) IGF axis (insulin-like growth factor [IGF]-1, total and intact IGF binding protein [IGFBP]-3 and IGFBP-4, and pregnancy-associated plasma protein [PAPP]-A) in 2 studies: (1) 18 individuals with early stage NAFLD versus 14 controls (study 1; early NAFLD study) and in (2) 31 individuals with biopsy proven NAFLD (15 with simple steatosis [SS] and 16 with nonalcoholic steatohepatitis [NASH]), vs 50 controls (24 lean and 26 obese) (study 2). Liver gene expression was assessed in 22 subjects (12 controls, 5 NASH, 5 NASH-related cirrhosis). Results Patients in early stages of NAFLD demonstrate higher fasting MPGF and lower incremental increase of glicentin during oral glucose tolerance test than controls. In more advanced stages, FSTL3 levels are higher in NASH than simple steatosis and, within NAFLD patients, in those with more severe lobular and portal inflammation. The IGF-1/intact IGFBP-3 ratio is lower in patients with liver fibrosis. Genes encoding follistatin, activin A, activin B, and the IGF-1 receptor are higher in NASH. Conclusion MPGF and glicentin may be involved in early stages of NAFLD, whereas FSTL3 and IGF-1/intact IGFBP3 in the progression to NASH and liver fibrosis respectively, suggesting potential as diagnostic markers or therapeutic targets.

scholarly journals 194 Designing non-toxic ligands against TB using data intensive genome level analysis

2015 ◽  
Vol 33 (sup1) ◽  
pp. 128-128
Author(s):  
Divneet Kaur ◽  
S.K. Brahmachari
Keyword(s):  
Data Intensive ◽  
Genome Level ◽  
Using Data ◽  
Level Analysis
Sign in / Sign up

Export Citation Format

Share Document