scholarly journals Estimation of heritability for nine common cancers using data from genome-wide association studies in Chinese population

2016 ◽  
Vol 140 (2) ◽  
pp. 329-336 ◽  
Author(s):  
Juncheng Dai ◽  
Wei Shen ◽  
Wanqing Wen ◽  
Jiang Chang ◽  
Tongmin Wang ◽  
...  
Keyword(s):  
Chinese Population ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Using Data

Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population

2012 ◽  
Vol 45 (4) ◽  
pp. 310-314 ◽  
Author(s):  
Lin-Dan Ji ◽  
Peng-Fei Chai ◽  
Bi-Bo Zhou ◽  
Nelson L. S. Tang ◽  
Wen-Hua Xing ◽  
...  
Keyword(s):  
Chinese Population ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population

2010 ◽  
Vol 95 (3) ◽  
pp. 1395-1403 ◽  
Author(s):  
Chloe Y. Y. Cheung ◽  
Annette W. K. Tso ◽  
Bernard M. Y. Cheung ◽  
Aimin Xu ◽  
K. L. Ong ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Chinese Population ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Obesity Susceptibility

scholarly journals Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana Viñuela ◽  
Arushi Varshney ◽  
Martijn van de Bunt ◽  
Rashmi B. Prasad ◽  
Olof Asplund ◽  
...  
Keyword(s):  
Large Scale ◽  
Association Studies ◽  
Cell Types ◽  
Genome Wide Association ◽  
Regulatory Sequences ◽  
Genome Wide Association Studies ◽  
Risk Variants ◽  
Genome Wide ◽  
Gwas Signal ◽  
Using Data

Abstract Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-scale resources. Here we explore the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glycemic traits, and human pancreatic islet transcription using data from 420 donors. We find: (a) 7741 cis-eQTLs in islets with a replication rate across 44 GTEx tissues between 40% and 73%; (b) marked overlap between islet cis-eQTL signals and active regulatory sequences in islets, with reduced eQTL effect size observed in the stretch enhancers most strongly implicated in GWAS signal location; (c) enrichment of islet cis-eQTL signals with T2D risk variants identified in genome-wide association studies; and (d) colocalization between 47 islet cis-eQTLs and variants influencing T2D or glycemic traits, including DGKB and TCF7L2. Our findings illustrate the advantages of performing functional and regulatory studies in disease relevant tissues.

An evaluation study of reported pancreatic adenocarcinoma risk-associated SNPs from genome-wide association studies in Chinese population

Pancreatology ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 931-935 ◽  
Author(s):  
Xiaoyi Wang ◽  
Xiaoling Lin ◽  
Rong Na ◽  
Deke Jiang ◽  
Pengyin Zhang ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Chinese Population ◽  
Association Studies ◽  
Evaluation Study ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

An evaluation study of reported pancreatic carcinoma risk-associated SNPs from genome-wide association studies in Chinese population

Pancreatology ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. S53
Author(s):  
Xiaoyi Wang ◽  
Xiaoling Lin ◽  
Rong Na ◽  
Pengyin Zhang ◽  
Ji Li ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Chinese Population ◽  
Association Studies ◽  
Evaluation Study ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Carcinoma Risk

scholarly journals Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95045 ◽  
Author(s):  
Yi-Cheng Chang ◽  
Pi-Hua Liu ◽  
Yu-Hsiang Yu ◽  
Shan-Shan Kuo ◽  
Tien-Jyun Chang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chinese Population ◽  
Association Studies ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Han Chinese Population ◽  
Risk Variants ◽  
Genome Wide
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