Assessment of Ethanol Exposure from Hand Sanitizer Use and Potential for Developmental Toxicity in Nursing Infants

2022 ◽  
Author(s):  
Alice A. Han ◽  
Amanda N. Buerger ◽  
Hannah Allen ◽  
Melissa Vincent ◽  
Stephanie A. Thornton ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Ethanol Exposure ◽  
Hand Sanitizer

Reversal of cardiomyopathy resulting from prenatal exposure to ethanol

1984 ◽  
Vol 42 ◽  
pp. 716-717
Author(s):  
C. Uphoff ◽  
C. Nyquist-Battie
Keyword(s):  
Prenatal Exposure ◽  
Heart Development ◽  
Membrane Integrity ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Pathological Changes ◽  
Prenatally Exposed ◽  
Inner Mitochondrial Membrane ◽  
Fetal Alcohol ◽  
Newborn Mice

Fetal Alcohol Syndrone (FAS) is a syndrome with characteristic abnormalities resulting from prenatal exposure to ethanol. In many children with FAS syndrome gross pathological changes in the heart are seen with septal defects the most prevalent abnormality recorded. Few studies in animal models have been performed on the effects of ethanol on heart development. In our laboratory, it has been observed that prenatal ethanol exposure of Swiss albino mice results in abnormal cardiac muscle ultrastructure when mice were examined at birth and compared to pairfed and normal controls. Fig. 1 is an example of the changes that are seen in the ethanol-exposed animals. These changes include enlarged mitochondria with loss of inner mitochondrial membrane integrity and loss of myofibrils. Morphometric analysis substantiated the presence of these alterations from normal cardiac ultrastructure. The present work was undertaken to determine if the pathological changes seen in the newborn mice prenatally exposed to ethanol could be reversed with age and abstinence.

Alterations in Ultrastructure of Skeletal Muscle From Newborn Guinea Pigs Following in Utero Exposure to Ethanol

1985 ◽  
Vol 43 ◽  
pp. 686-687
Author(s):  
C. Uphoff ◽  
C. Nyquist-Battie ◽  
T.B. Cole
Keyword(s):  
Skeletal Muscle ◽  
Guinea Pigs ◽  
Muscle Development ◽  
In Utero ◽  
Ethanol Exposure ◽  
Prenatally Exposed ◽  
Chronic Alcoholic ◽  
Test Kit ◽  
Food And Water Intake ◽  
Post Intubation

Ultrastructural alterations of skeletal muscle have been observed in adult chronic alcoholic patients. However, no such study has been performed on individuals prenatally exposed to ethanol. In order to determine if ethanol exposure in utero in the latter stages of muscle development was deleterious, skeletal muscle was obtained from newborn guinea pigs treated in the following manner. Six Hartly strain pregnant guinea pigs were randomly assigned to either the ethanol or the pair-intubated groups. Twice daily the 3 ethanol-treated animals were intubated with Ensure (Ross Laboratories) liquid diet containing 30% ethanol (6g/Kg pre-pregnant body weight per day) from day 35 of gestation until parturition at day 70±1 day. Serum ethanol levels were determined at 1 hour post-intubation by the Sigma alcohol test kit. For pair-intubation the Ensure diet contained sucrose substituted isocalorically for ethanol. Both food and water intake were monitored.

Second-phase validation of developmental toxicity test using embryoid body's area

2019 ◽  
Author(s):  
Jae-Hwan Lee ◽  
Seon Mi Park ◽  
Eui-Man Jung ◽  
Eui-Bae Jeung
Keyword(s):  
Toxicity Test ◽  
Developmental Toxicity ◽  
Second Phase

Developmental Toxicity Potential of Hydroxyuera, a Positive Control, in Rabbits

1988 ◽  
Author(s):  
Valerie G. Coppes ◽  
Charlotte L. Speckman ◽  
Jr Korte ◽  
Don W.
Keyword(s):  
Developmental Toxicity ◽  
Positive Control ◽  
Toxicity Potential

Public Awareness of Preventive Measures against COVID-19: A Google Trends Analysis (Preprint)

2020 ◽  
Author(s):  
Alex Mok ◽  
Oliver Oi Yat Mui ◽  
Kwan Pui Tang ◽  
Chi-Fai NG ◽  
Sunny Hei Wong ◽  
...  
Keyword(s):  
Public Health ◽  
Temporal Trend ◽  
Preventive Measures ◽  
Public Awareness ◽  
Google Trends ◽  
Online Searching ◽  
Effective Measure ◽  
Heat Maps ◽  
Hand Sanitizer ◽  
Incidence Data

BACKGROUND The 2019 coronavirus pandemic (COVID-19) has led to increase in global awareness of related public health preventive measures. The public awareness can be reflected by online searching trends of major search engines, namely Google Trends. OBJECTIVE This study aims to interpret online searches of COVID-19 related public health preventive measures and to identify possible correlations between early search trends and progression of the pandemic. METHODS Search data from five queries “Mask”, “Hand Washing”, “Social Distancing”, “Hand Sanitizer”, and “Disinfectant” were extracted from Google Trends (GT) in the form of Relative Search Volumes (RSV). Global incidence data of COVID-19 was obtained from January 1st to June 30th 2020. Subsequently, the data were analyzed and illustrated in forms of a global temporal RSV trend diagram, a geographical RSV distribution chart, scatter graphs comparing regional RSV with average daily cases; and heat-maps comparing temporal trend of RSV with average daily cases. RESULTS Global temporal trend revealed multiple surges in RSV, which were temporally associated with certain COVID news events. Geographical distribution showed differences of query interests among regions. Although scatter graphs failed to illustrate strong correlations between regional RSV and average daily cases, the heat-maps were able to demonstrate patterns of early RSV peaks in countries with lower average daily cases, for queries “Mask”, “Hand Sanitizer”, and “Disinfectant”, upon incorporating with the temporal element into analysis. CONCLUSIONS Early public awareness of multiple preventive measures was observed in countries with lower daily average cases. Public health authorities may look into early public awareness as an effective measure for future disease control.

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