Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

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P487 The long-term prognostic value of elevated cardiac troponins in patients undergoing major vascular surgery is not influence by renal function or skeletal muscle injury

European Heart Journal ◽

10.1016/s0195-668x(03)93925-x ◽

2003 ◽

Vol 24 (5) ◽

pp. 74

Author(s):

D POLDERMANS

Keyword(s):

Skeletal Muscle ◽

Renal Function ◽

Vascular Surgery ◽

Prognostic Value ◽

Muscle Injury ◽

Skeletal Muscle Injury ◽

Major Vascular Surgery ◽

Cardiac Troponins

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Load-Bearing in the Ovine Medial Tibial Condyle: Effect of Meniscectomy

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1633027 ◽

1993 ◽

Vol 06 (02) ◽

pp. 100-104 ◽

Cited By ~ 8

Author(s):

D. M. Pickles ◽

C. R. Bellenger

Keyword(s):

Knee Joint ◽

Contact Area ◽

Mammalian Species ◽

Total Removal ◽

Load Bearing ◽

Human Knee ◽

Biochemical Effects ◽

Pressure Sensitive ◽

Medial Meniscectomy ◽

Tibial Condyle

SummaryTotal removal of a knee joint meniscus is followed by osteoarthritis in many mammalian species. Altered load-bearing has been observed in the human knee following meniscectomy but less is known about biochemical effects of meniscectomy in other species. Using pressure sensitive paper in sheep knee (stifle) joints it was found that, for comparable loads, the load-bearing area on the medial tibial condyle was significantly reduced following medial meniscectomy. Also, for loads of between 50 N and 500 N applied to the whole joint, the slope of the regression of contact area against load was much smaller. Following medial meniscectomy, the ability to increase contact area as load increased was markedly reduced.The load bearing area on the medial tibial condyle was reduced following meniscectomy.

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