Antioxidants and Biochemical Effects of Oral Administration of Red Pepper Aqueous Extract on Rabbit's Liver Treated with Cholesterol

2019 ◽  
Author(s):  
Hadeel T. S. Al-Ishlash ◽  
Muntaha M. D. Al-Kattan
Keyword(s):  
Oral Administration ◽  
Aqueous Extract ◽  
Red Pepper ◽  
Biochemical Effects

scholarly journals STUDIES ON BIOCHEMICAL EFFECTS OF AQUEOUS EXTRACT OF CARICA PAPAYA LEAF ON ALLOXAN-INDUCED DIABETIC ALBINO RATS

Food Biology ◽  
1970 ◽  
pp. 28-35
Author(s):  
EZEKWE AHAMEFULA ◽  
NWADIKE CONSTANCE ◽  
EBOAGWU IJEOMA ◽  
ODIKA PRINCE, NJOKU SAMUEL
Keyword(s):  
Renal Function ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Pharmacological Property ◽  
Carica Papaya ◽  
Diabetic Control ◽  
Albino Rats ◽  
Control Test ◽  
Biochemical Effects ◽  
Wistar Strain

Studies on biochemical effects of aqueous extract of Carica papaya leaf on alloxan-induced diabetic albino rats were undertaken. One hundred albino rats of Wistar strain were obtained and divided into five groups of twenty rats each and properly treated with the aqueous extract after four out of the five groups were induced with diabetes. The diabetic induced groups were diabetic control, test groups I (treated with 200 mg/kg) and II (treated with 50 mg/kg), and reference (treated with the standard glibenclamide). The diabetic free group was designated as normal control. Results obtained revealed that oral administration of aqueous extract of C. papaya leaf on alloxan-induced diabetic albino rats significantly reversed the damage associated with alloxan-induced diabetes revealing its hypoglycemic, liver and renal function integrity effects. The presence of phytochemicals and phytonutrients found in C. papaya could explain the observed pharmacological property of the studied extract. This study has revealed the biochemical effects of aqueous extract of C. papaya leaf on alloxan-induced diabetic albino rats.

Antihyperglycemic, Antihyperlipidemic and Antioxidant Effects of Cotula cinerea (Del) in Normal and Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 20 (9) ◽  
pp. 1504-1513 ◽  
Author(s):  
Ayoub Amssayef ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Glucose Tolerance ◽  
Oral Administration ◽  
Beneficial Effect ◽  
Aqueous Extract ◽  
Aerial Part ◽  
Diabetic Rats ◽  
Histopathological Analysis ◽  
Phytochemical Screening ◽  
Cotula Cinerea

Aims: The current investigation aimed to assess the antioxidant, antidiabetic and antilipidemic effects of the aqueous extract of aerial part of Cotula cinerea (C. cinerea). Background: Cotula cinerea (Del). which belongs to the Asteraceae family is commonly used traditionally for the treatment of diabetes. Objective: The objective of the study was to study the effect of the aqueous C. cinerea extract on glucose and lipid metabolism in normal and streptozotocin-induced diabetic rats using a single and repeated oral administration. Methods: A preliminary phytochemical screening and the quantification of phenolic and flavonoid contents as well as the antioxidant activity using three methods (DPPH, FRAP and ABTS) were carried out. The effect of a single and repeated (15 days of treatment) oral administration of the aqueous extract of aerial part of Cotula cinerea (AEAPCC) at a dose of 20 mg/kg on glucose and lipid profile was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas and liver was carried out according to the Hematoxylin-Eosin method. Results: AEAPCC (20 mg/kg) showed a significant blood glucose-lowering activity in both normal and diabetic rats after a single and repeated oral administration during 15 days. The aqueous extract was also able to decrease the plasma triglycerides levels in both normal and diabetic rats after 15 days of oral treatment at a dose of 20 mg/Kg while no effect was observed on plasma cholesterol levels. In addition, the results show that AEAPCC exhibits an in vitro antioxidant activity using different tests. Histopathological analysis of the pancreas and liver of AEAPCC-treated diabetic rats has revealed that AEAPCC had a beneficial effect on the architecture of these organs while no improvement of glucose tolerance was noticed using the glucose tolerance test. Furthermore, the results showed that the extract is rich in several phytochemical compounds and exhibited an important antioxidant activity. The phytochemical screening revealed that AEAPCC contains polyphenolic compounds, flavonoids, tannins, alkaloids, saponins, quinones, sterols, terpenoids, anthroquinones and reducing sugars. Whereas, it is free from glycosides. Conclusion: In conclusion, this study demonstrates that Cotula cinerea possesses a beneficial effect on diabetes. Further investigations are required to study the mechanism of action of the antidiabetic effect of this plant.

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet

2018 ◽  
Vol 28 (5) ◽  
pp. 1197-1203 ◽  
Author(s):  
Mohammad Mahdi Zangeneh ◽  
Saman Salmani ◽  
Akram Zangeneh ◽  
Reza Khedri ◽  
Mohammad Saeid Zarei
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat ◽  
Biochemical Effects ◽  
Tragopogon Graminifolius ◽  
Liver Tissues

scholarly journals Subchronic toxcity study of Khaya senegalensis aqueous extract in rats

2021 ◽  
Vol 41 (1) ◽  
pp. 235-243
Author(s):  
K. T. Biobaku ◽  
A. A. Yusuf ◽  
F. M. Mshelbwala ◽  
E. S. Ajibola ◽  
B. S Okediran ◽  
...  
Keyword(s):  
Blood Cell ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Haemoglobin Concentration ◽  
Glucose Levels ◽  
Khaya Senegalensis ◽  
High Doses ◽  
Group B

This study was carried out to investigate the sub chronic effects of oral administration of different doses: 100mg/kg, 400mg/kg, l600mg/kg, 6400mg/kg of aqueous extract of Khaya senegalensis in wistar rats. The rats were randomly separated to groups "A-G". The group "A" was considered as a non treated control. The other groups B, C, D and E respectively, were test groups and were treated with the extract. The biochemical and haematological parameters were assessed after 21 days of oral administration of the extract. The liver, kidney, pancreas, and heart of various experimental rats were harvested and preserved. The parenchymal tissues were fixed and using a microtome prepared to slides. Histopathological changes were observed using standard methods. There were no significant differences in white blood cell (WBC), Differential leucocytes count (DLC), haemoglobin concentration, packed cell volume (PCV) and Red Blood Cell count (RBC) respectively. There was however a significant (P<0.05) decrease in the serum Alanine amino transferase (ALT) in groups B, C and D and also a significant (p<0.05) decrease in AST levels in group B and E. The blood glucose levels also decreased significantly (P<0.05) in groups concentration in groups C, D, and E. Histopathological examination showed moderate degenerative changes and congestions in the livers and kidneys and pancreas in all treated groups. This gave an insiglht on the effects of oral administration of an aqueous extract of Khaya senegalensis on the haematological and biochemical parameters, with the related tissue pathology, in experimental wistar rats. Conclusion could be made that care should be taken in prolonged administration of high doses of aqueous extract of  Khaya senegalensis man and animals.

scholarly journals Physiological study to investigate the activity of an aqueous extract ofCinnamomum cassiabark on the blood glucose levels in healthy and diabetic rats induced by streptozotocin (stz)

2016 ◽  
Vol 13 (4) ◽  
pp. 681-693
Author(s):  
Baghdad Science Journal
Keyword(s):  
Blood Glucose ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Physiological Study ◽  
Cinnamomum Cassia ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Single Oral Administration

The present study was investigated the activity of aqueous extract from Cinnamomum cassia bark on the blood glucose levels in healthy and diabetic rats induced by Streptozotcin (STZ). In healthy rats the blood glucose levels were slightly decreased after six hoursof single oral administration with dose (25 mg/kg) of body wight, as well as four weeks after twice daily repeated oral administration of aqueous extract of Cinnamomum cassia bark. In streptozotocin induced diabetic rats we absorved high significant decreased (p

scholarly journals Leaf Aqueous Extract of Argania spiniosa Exhibits Antihyperglycemic Effect in Diabetic Rats

2019 ◽  
Vol 17 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Morad Hebi ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Blood Glucose ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Argania Spinosa ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Leaf Aqueous Extract

Introduction: Argania Spinosa L. (Sapotaceae) is an endemic species from south-western Morocco. This plant has many traditional uses including its use in the treatment of diabetes. Objective: The objective of the study was to evaluate the antidiabetic activity of Argania Spinosa Leaf Aqueous Extract (A.S.L.A.E). Methods: The antidiabetic effect of A.S.L.A.E was evaluated in both normal and streptozotocin (STZ)-induced diabetic rats treated at a dose of 20 mg/kg body weight for 15 days. The histopathological changes in the liver were evaluated. In addition, the antioxidant activity of this extract was also studied. Results: Single oral administration of A.S.L.A.E (20 mg/kg) showed no significant change in blood glucose levels in both normal and STZ induced diabetic rats after 6 hours of administration. Furthermore, in normal rats, repeated oral administration of A.S.L.A.E reduced blood glucose levels. Moreover, blood glucose levels decreased in STZ diabetic rats after fifteen days of treatment. According to the oral glucose tolerance test, the A.S.L.A.E (20 mg/kg) was shown to prevent significantly the increase in blood glucose levels in normal treated rats. Moreover, A.S.L.A.E showed antioxidant activity. Conclusion: The results show that Argania spinosa leaf aqueous extract possesses significant antihyperglycemic activity.

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