Lactobacillus cell‐free supernatant as a novel bioagent and biosurfactant against Pseudomonas aeruginosa in the prevention and treatment of orthopedic implant infection

2021 ◽  
Author(s):  
Augustina Jeyanathan ◽  
Rita Ramalhete ◽  
Gordon Blunn ◽  
Hannah Gibbs ◽  
Cyrus Anthony Pumilia ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Orthopedic Implant ◽  
Implant Infection ◽  
Cell Free Supernatant ◽  
Prevention And Treatment

Biofilm formation of meat-borne Salmonella enterica and inhibition by the cell-free supernatant from Pseudomonas aeruginosa

Food Control ◽  
2013 ◽  
Vol 32 (2) ◽  
pp. 650-658 ◽  
Author(s):  
Hu-Hu Wang ◽  
Ke-Ping Ye ◽  
Qiu-Qin Zhang ◽  
Yang Dong ◽  
Xing-Lian Xu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Salmonella Enterica ◽  
Biofilm Formation ◽  
Cell Free Supernatant

Animal Models of Orthopedic Implant Infection

1998 ◽  
Vol 11 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Yuehuei H. An ◽  
Richard J. Friedman
Keyword(s):  
Animal Models ◽  
Orthopedic Implant ◽  
Implant Infection

scholarly journals Antibacterial and Anti-Inflammatory Coating Materials for Orthopedic Implants: A Review

Coatings ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1401
Author(s):  
Gang Tan ◽  
Jing Xu ◽  
Walter Munesu Chirume ◽  
Jieyu Zhang ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Hot Spot ◽  
Orthopedic Implants ◽  
Implant Failure ◽  
Social Benefits ◽  
Orthopedic Implant ◽  
Common Complication ◽  
Coating Materials ◽  
Implant Infection ◽  
Implant Coating ◽  
Anti Inflammatory

Orthopedic implant failure is the most common complication of orthopedic surgery, causing serious trauma and resulting in a tremendous economic burden for patients. There are many reasons for implant failure, among which peri-implant infection (or implant-related infection) and aseptic loosening are the most important. At present, orthopedic doctors have many methods to treat these complications, such as revision surgery, which have shown good results. However, if peri-implant infection can be prevented, this will bring about significant social benefits. Many studies have focused on adding antibacterial substances to the implant coating, and with a deeper understanding of the mechanism of implant failure, adding such substances by different modification methods has become a research hot spot. This review aims to summarize the antibacterial and anti-inflammatory substances that can be used as coating materials in orthopedic implants and to provide a reference for the prevention and treatment of implant failure caused by implant-related infection and excessive inflammation.

scholarly journals A DESCRIPTIVE STUDY OF BACTERIOLOGICAL SPECTRUM OF ORTHOPEDIC IMPLANT INFECTION IN CLOSED FRACTURES

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Rajendra Kumar Goyal
Keyword(s):  
Adverse Outcome ◽  
Descriptive Study ◽  
Orthopedic Implant ◽  
Significant Morbidity ◽  
Implant Infection ◽  
Gram Negative ◽  
Local Tenderness ◽  
Closed Fractures ◽  
Culture Positive ◽  
Morbidity Cost

Background- Surgical Site Infection (SSI) is defined as pain associated with erythema, induration, local tenderness, pus discharge or any culture positive or negative discharge from a surgically created wound. Methods- Descriptive type of Observational study conducted on Patients in the department of Orthopaedics. Results- 6.00% patients have wound infection.    Gram positive 83.33% patients have found with Staph. Aureus and Gram- negative 16.67% patients have found with Pseudomonas. Conclusion- Infection in closed fractures with implants was quite high. The adverse outcome of SSIs related to a clean orthopedic surgical procedure can be associated with significant morbidity, cost, and even mortality.  Keywords- SSI, Closed, Implants

scholarly journals Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Takaaki Furusawa ◽  
Hidetomo Iwano ◽  
Hidetoshi Higuchi ◽  
Masaru Usui ◽  
Fumito Maruyama ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Host Range ◽  
Complete Genome ◽  
Broad Host Range ◽  
Bacteriophage Therapy ◽  
Genome Sequences ◽  
Prevention And Treatment

Pseudomonas aeruginosa is an important cause of racehorse keratitis. Bacteriophage therapy has the potential to aid in the prevention and treatment of diseases caused by P. aeruginosa . We present here the complete genome sequences of two phages, ΦR18 and ΦS12-1, which exhibit infectivity for a broad range of P. aeruginosa isolates.

Novel Surface Coatings Modulating Eukaryotic Cell Adhesion and Preventing Implant Infection

2009 ◽  
Vol 32 (9) ◽  
pp. 655-662 ◽  
Author(s):  
JÜRGEN Groll ◽  
JÖRG Fiedler ◽  
Kristina Bruellhoff ◽  
Martin Moeller ◽  
Rolf E. Brenner
Keyword(s):  
Cell Adhesion ◽  
Bacterial Adhesion ◽  
Biofilm Formation ◽  
Eukaryotic Cell ◽  
Organic Coating ◽  
Surface Coatings ◽  
Osteoblastic Cells ◽  
Orthopedic Implant ◽  
Small Peptide ◽  
Implant Infection

Poor osseointegration and bacterial infection are major causes of orthopedic implant failure. Both problems arise from passive unspecific protein coating that may not optimally support adhesion of osteoblastic cells and which enable bacterial adhesion that subsequently results in biofilm formation. This review addresses emerging concepts of preventing unspecific protein adsorption and biofilm formation by organic coating systems. We especially focus on recent concepts that additionally allow functionalization for preferential cell adhesion using cell adhesion mediating small peptide sequences that do not induce bacterial adherence. One promising approach that is presented and discussed within this context is the use of NCO-sP(EO-stat-PO).

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