Long-Term and Recent Weight Change Are Associated With Reduced Peripheral Bone Density, Deficits in Bone Microarchitecture, and Decreased Bone Strength: The Framingham Osteoporosis Study

Context Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). Objective To elucidate both cortical and trabecular bone microarchitecture and estimated bone strength in men with active acromegaly or GHD compared to healthy controls. Design and subjects Cross-sectional study at a clinical research center, including 48 men (16 with acromegaly, 16 with GHD and 16 healthy controls). Outcome measures Areal bone mineral density (aBMD), cortical and trabecular bone microarchitecture and estimated bone strength (µFEA) at the radius and tibia. Results aBMD was not different between the 3 groups at any skeletal site. At the radius, patients with acromegaly had greater cortical area (P < 0.0001), cortical thickness (P = 0.0038), cortical pore volume (P < 0.0001) and cortical porosity (P = 0.0008), but lower trabecular bone density (P = 0.0010) compared to controls. At the tibia, patients with acromegaly had lower trabecular bone density (P = 0.0082), but no differences in cortical bone microstructure. Compressive strength and failure load did not significantly differ between groups. These findings persisted after excluding patients with hypogonadism. Bone microarchitecture was not deficient in patients with GHD. Conclusions Both cortical and trabecular microarchitecture are altered in men with acromegaly. Our data indicate that GH excess is associated with distinct effects in cortical vs trabecular bone compartments. Our observations also affirm the limitations of aBMD testing in the evaluation of patients with acromegaly.

Download Full-text

Effect of odanacatib on bone density and estimated bone strength in postmenopausal women: a CT-based sub-study of the phase 3 long-term odanacatib fracture trial (LOFT)

Bone Abstracts ◽

10.1530/boneabs.5.oc3.1 ◽

2016 ◽

Author(s):

Bente Langdahl ◽

Villiers Tobias De ◽

Tony M Keaveny ◽

Klaus Engelke ◽

Harry Genant ◽

...

Keyword(s):

Bone Density ◽

Postmenopausal Women ◽

Bone Strength ◽

Phase 3

Download Full-text

Decreased axial and peripheral bone density in patients taking long-term warfarin

QJM ◽

10.1093/oxfordjournals.qjmed.a069112 ◽

1995 ◽

Keyword(s):

Bone Density ◽

Peripheral Bone

Download Full-text

Compromised Bone Microarchitecture and Estimated Bone Strength in Young Adults With Cystic Fibrosis

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2014-1982 ◽

2014 ◽

Vol 99 (9) ◽

pp. 3399-3407 ◽

Cited By ~ 26

Author(s):

Melissa S. Putman ◽

Carly E. Milliren ◽

Nicholas Derrico ◽

Ahmet Uluer ◽

Leonard Sicilian ◽

...

Keyword(s):

Cystic Fibrosis ◽

Young Adults ◽

Bone Density ◽

Fracture Risk ◽

Healthy Volunteers ◽

Trabecular Bone ◽

Bone Strength ◽

Bone Microarchitecture ◽

Trabecular Microarchitecture ◽

Cross Sectional

Context: Young adults with cystic fibrosis (CF) are at risk for low bone density and fractures, but the underlying alterations in bone microarchitecture that may contribute to their increased fracture risk are currently unknown. Objective: The main goal of this study was to use high-resolution peripheral quantitative computed tomography (HR-pQCT) to characterize the bone microarchitecture, volumetric bone mineral density (vBMD), and estimated strength of the radius and tibia in young adults with CF compared with healthy volunteers. Design and Setting: This was a cross-sectional study at an outpatient clinical research center within a tertiary academic medical center. Participants: Thirty young adults with CF, 18 to 40 years of age, were evaluated and compared with 60 healthy volunteers matched by age (±2 years), gender, and race. Main Outcome Measures: The primary outcomes were HR-pQCT–derived cortical and trabecular vBMD, bone microarchitecture, and estimates of bone strength. Results: At the radius and tibia, young adults with CF had smaller bone cross-sectional area and lower vBMD. Cortical and trabecular microarchitecture were compromised at both sites, most notably involving the trabecular bone of the tibia. These differences translated into lower estimated bone strength both at the radius and tibia. After accounting for body mass index differences, young adults with CF had lower bone area and estimated bone strength at the radius and had compromised trabecular microarchitecture and lower total and trabecular vBMD and estimated bone strength at the tibia. Alterations in trabecular bone density and microarchitecture and estimated strength measures of the tibia were also greater than expected based on dual-energy x-ray absorptiometry-derived areal BMD differences. Conclusions: Young adults with CF have compromised bone microarchitecture and lower estimated bone strength at both the radius and tibia, even after accounting for their smaller body size. These skeletal deficits likely explain the higher fracture risk observed in young adults with CF.

Download Full-text

A risk of developing osteopenia in children undergoing preventive treatment for tuberculosis infection

Voprosy detskoj dietologii ◽

10.20953/1727-5784-2021-1-11-15 ◽

2021 ◽

Vol 19 (1) ◽

pp. 11-15

Author(s):

N.Yu. Krutikova ◽

◽

A.V. Teshchenkov ◽

A.V. Krikova ◽

T.G. Avdeeva ◽

...

Keyword(s):

Bone Density ◽

Bone Strength ◽

Comparison Group ◽

Latent Tuberculosis ◽

Preventive Treatment ◽

Tuberculosis Infection ◽

Control Group ◽

Experimental Group ◽

Tubular Bones

Objective. To study bone strength in children with latent tuberculosis infection who receive anti-tuberculosis drugs. Patients and methods. A quantitative ultrasound examination of the strength of the tubular bones of the upper and lower extremities was conducted in 120 children with mycobacteria tuberculosis infection (experimentak group). У 73 children who received preventive treatment with anti-tuberculosis drugs (isoniazid, pyrazinamide) bone strength examination was repeated after 6 months (comparison group). The control group comprised 42 children belonging to the 2nd health status group. Results. At the first examination, according to osteodensitometry, children of the experimental group had a decreased bone density in tubular bones as compared to the age-related norms in 34.2% of cases, which had no statistically significant differences with the control group. The children of the comparison group were examined after 6 months, about 60% of children had a decrease of bone density of varied degree, the average Z-score 1.5 ± 0.8, which is significantly lower than in the experimental group. According to the study results, a significant statistical correlation was found between the intake of anti-tuberculosis drugs and bone strength in children with latent tuberculosis χ2 = 10.588, р < 0.012. Conclusion. As was found, a long-term intake of anti-tuberculosis drugs has an effect on bone strength in children. In the outpatient settings, clinical monitoring of bone strength permits to ensure the safety of the administered long-term preventive therapy of tuberculosis. Key words: children, bone strength, tuberculosis, treatment, osteodensitometry, chemoprophylaxis, anti-tuberculosis drugs

Download Full-text