Hemoglobin degradation lipid peroxidation, and inhibition of na+/k+-atpase in rat erythrocytes exposed to acrylonitrile

1990 ◽  
Vol 5 (4) ◽  
pp. 221-227 ◽  
Author(s):  
Mohammed Y. H. Farooqui ◽  
Mohammad M. Mumtaz ◽  
Burhan I. Ghanayem ◽  
Ahmed E. Ahmed
Keyword(s):  
Lipid Peroxidation ◽  
Rat Erythrocytes ◽  
Hemoglobin Degradation

scholarly journals In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

2013 ◽  
Vol 64 (4) ◽  
pp. 553-559 ◽  
Author(s):  
Seyed Fazel Nabavi ◽  
Solomon Habtemariam ◽  
Antoni Sureda ◽  
Akbar Hajizadeh Moghaddam ◽  
Maria Daglia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Vitamin C ◽  
Gallic Acid ◽  
Sodium Fluoride ◽  
Enzyme Activities ◽  
Control Group ◽  
Rat Erythrocytes ◽  
Pre Treatment

Abstract Gallic acid has been identified as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fluoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m-3 for one week). Gallic acid at 10 mg kg-1 and 20 mg kg-1 and vitamin C for positive controls (10 mg kg-1) were administered daily intraperitoneally for one week prior to NaF administration. Thiobarbituric acid reactive substances, antioxidant enzyme activities (superoxide dismutase and catalase), and the level of reduced glutathione were evaluated in rat erythrocytes. Lipid peroxidation in NaF-exposed rats significantly increased (by 88.8 %) when compared to the control group (p<0.05). Pre-treatment with gallic acid suppressed lipid peroxidation in erythrocytes in a dose-dependent manner. Catalase and superoxide dismutase enzyme activities and glutathione levels were reduced by NaF intoxication by 54.4 %, 63.69 %, and 42 % (p<0.001; vs. untreated control group), respectively. Pre-treatment with gallic acid or vitamin C significantly attenuated the deleterious effects. Gallic acid isolated from Peltiphyllum peltatum and vitamin C mitigated the NaF-induced oxidative stress in rat erythrocytes.

scholarly journals Lipid peroxidation induced by copper in rat erythrocytes.

Eisei kagaku ◽  
1991 ◽  
Vol 37 (2) ◽  
pp. 137-142 ◽  
Author(s):  
YASUYOSHI SAYATO ◽  
KATSUHIKO NAKAMURO ◽  
TATSUYA HASEGAWA
Keyword(s):  
Lipid Peroxidation ◽  
Rat Erythrocytes

Metabolism of lipid peroxidation product, 4-hydroxynonenal (HNE) in rat erythrocytes: role of aldose reductase

2000 ◽  
Vol 29 (7) ◽  
pp. 642-651 ◽  
Author(s):  
Sanjay Srivastava ◽  
Bharat L Dixit ◽  
Jian Cai ◽  
Silky Sharma ◽  
Harrell E Hurst ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Aldose Reductase ◽  
Lipid Peroxidation Product ◽  
Rat Erythrocytes ◽  
Peroxidation Product

The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: role of vitamins E and C

2002 ◽  
Vol 21 (12) ◽  
pp. 681-685 ◽  
Author(s):  
I Altuntas ◽  
N Delibas ◽  
R Sutcu
Keyword(s):  
Lipid Peroxidation ◽  
Body Weight ◽  
Single Dose ◽  
Treated Group ◽  
Control Group ◽  
Organophosphate Insecticide ◽  
Rat Erythrocytes ◽  
Vitamins E And C ◽  
Anti Oxidant ◽  
C 30

The effects of organophosphate insecticide methidathion (MD) on lipid peroxidation and anti-oxidant enzymes and the ameliorating effects of a combination of vitamins E and C against MD toxicity were evaluated in rat erythrocytes. Experimental groups were: control group, MD-treated group (MD), and MD+vitamin E+vitamin Ctreated group (MD+Vit). MD and MD+Vit groups were treated orally with a single dose of 8 mg/kg MD body weight at 0 hour. Vitamins E and C were injected at doses of 150 mg/kg body weight, i.m. and 200 mg/kg body weight, i.p., respectively, 30 min after the treatment of MD in the MD+Vit group. Blood samples were taken 24 hours after the MD administration. The level of malondialdehyde (MDA), and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were studied in the erythrocytes. MDA level increased significantly in the MD group compared to the control group (P <0.05) and decreased significantly in the MD+Vit group compared to the MD group (P <0.05). The activities of SOD, GSH-Px, and CAT decreased in the MD group compared to the control group (P<0.05). Only GSH-Px activity increased in the MD+Vit group compared with the MD group. These results suggest that treating rats with MD increases LPO and decreases anti-oxidant enzyme activities in erythrocytes. Furthermore, single-dose treatment with a combination of vitamins E and C 30 min after the administration of MD can reduce LPO caused by MD.

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