scholarly journals Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes

2008 ◽  
Vol 105 (6) ◽  
pp. 1430-1436 ◽  
Author(s):  
Hideaki Miyoshi ◽  
James W. Perfield ◽  
Martin S. Obin ◽  
Andrew S. Greenberg
Keyword(s):  
Droplet Size ◽  
Lipid Droplet ◽  
Adipose Triglyceride Lipase ◽  
Triglyceride Lipase ◽  
Lipid Droplet Size

scholarly journals Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

2019 ◽  
Vol 218 (10) ◽  
pp. 3320-3335 ◽  
Author(s):  
Micah B. Schott ◽  
Shaun G. Weller ◽  
Ryan J. Schulze ◽  
Eugene W. Krueger ◽  
Kristina Drizyte-Miller ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Western Blot ◽  
Droplet Size ◽  
Lipid Droplet ◽  
Adipose Triglyceride Lipase ◽  
Triglyceride Lipase ◽  
Lipid Droplet Size ◽  
Acidic Vesicles ◽  
New Evidence ◽  
Synergistic Relationship

Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a selective autophagic mechanism called lipophagy, but the relative contributions of these seemingly distinct pathways remain unclear. We find that inhibition of lipolysis, lipophagy, or both resulted in similar overall LD content but dramatic differences in LD morphology. Inhibition of the lipolysis enzyme adipose triglyceride lipase (ATGL) resulted in large cytoplasmic LDs, whereas lysosomal inhibition caused the accumulation of numerous small LDs within the cytoplasm and degradative acidic vesicles. Combined inhibition of ATGL and LAL resulted in large LDs, suggesting that lipolysis targets these LDs upstream of lipophagy. Consistent with this, ATGL was enriched in larger-sized LDs, whereas lipophagic vesicles were restricted to small LDs as revealed by immunofluorescence, electron microscopy, and Western blot of size-separated LDs. These findings provide new evidence indicating a synergistic relationship whereby lipolysis targets larger-sized LDs to produce both size-reduced and nascently synthesized small LDs that are amenable for lipophagic internalization.

scholarly journals Seasonal and photoperiodic effects on lipid droplet size and lipid peroxidation in the brown adipose tissue of bank voles (Myodes glareolus)

2012 ◽  
Vol 57 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Elżbieta Bonda-Ostaszewska ◽  
Tadeusz Włostowski ◽  
Alicja Krasowska ◽  
Paweł Kozłowski
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Droplet Size ◽  
Lipid Droplet ◽  
Myodes Glareolus ◽  
Bank Voles ◽  
Brown Adipose ◽  
Lipid Droplet Size

scholarly journals Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding

Obesity ◽  
2017 ◽  
Vol 25 (12) ◽  
pp. 2079-2087 ◽  
Author(s):  
Jeffrey D. Covington ◽  
Darcy L. Johannsen ◽  
Paul M. Coen ◽  
David H. Burk ◽  
Diana N. Obanda ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Droplet Size ◽  
Lipid Droplet ◽  
Total Lipid ◽  
Lipid Content ◽  
Total Lipid Content ◽  
Intramyocellular Lipid ◽  
Lipid Droplet Size

scholarly journals Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes

2017 ◽  
Vol 292 (26) ◽  
pp. 10824-10834 ◽  
Author(s):  
Yuki Nishimoto ◽  
Shinsuke Nakajima ◽  
Sanshiro Tateya ◽  
Masayuki Saito ◽  
Wataru Ogawa ◽  
...  
Keyword(s):  
Cell Death ◽  
Dna Fragmentation ◽  
Droplet Size ◽  
Lipid Droplet ◽  
Specific Protein ◽  
Brown Adipocytes ◽  
Lipid Droplet Size

scholarly journals Soluble Non-Starch Polysaccharides Derived from Complex Food Matrices Do Not Increase Average Lipid Droplet Size during Gastric Lipid Emulsification in Rats

1997 ◽  
Vol 127 (11) ◽  
pp. 2246-2252 ◽  
Author(s):  
Annette J. Fillery-Travis ◽  
Jenny M. Gee ◽  
Keith W. Waldron ◽  
Margaret M. Robins ◽  
Ian T. Johnson
Keyword(s):  
Droplet Size ◽  
Lipid Droplet ◽  
Lipid Droplet Size ◽  
Food Matrices

scholarly journals The effect of lipid droplet size on satiety and peptide secretion is intestinal site-specific

2012 ◽  
Vol 31 (4) ◽  
pp. 535-542 ◽  
Author(s):  
P.W. Jeroen Maljaars ◽  
Robert J.P. van der Wal ◽  
Tom Wiersma ◽  
Harry P.F. Peters ◽  
Edward Haddeman ◽  
...  
Keyword(s):  
Droplet Size ◽  
Lipid Droplet ◽  
Site Specific ◽  
Lipid Droplet Size ◽  
Peptide Secretion

scholarly journals The N-terminal Region of Comparative Gene Identification-58 (CGI-58) Is Important for Lipid Droplet Binding and Activation of Adipose Triglyceride Lipase

2010 ◽  
Vol 285 (16) ◽  
pp. 12289-12298 ◽  
Author(s):  
Astrid Gruber ◽  
Irina Cornaciu ◽  
Achim Lass ◽  
Martina Schweiger ◽  
Margret Poeschl ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Terminal Region ◽  
Gene Identification ◽  
Adipose Triglyceride Lipase ◽  
Triglyceride Lipase

scholarly journals Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein.

2013 ◽  
Vol 288 (15) ◽  
pp. 10952-10952 ◽  
Author(s):  
Hong Wang ◽  
Ming Bell ◽  
Urmila Sreenivasan ◽  
Hong Hu ◽  
Jun Liu ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Adipose Triglyceride Lipase ◽  
Triglyceride Lipase ◽  
Perilipin 5
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