Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide

2016 ◽  
Vol 118 (1) ◽  
pp. 182-190 ◽  
Author(s):  
Mario F. Muñoz ◽  
Sandro Argüelles ◽  
Mercedes Cano ◽  
Francesco Marotta ◽  
Antonio Ayala
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Cumene Hydroperoxide ◽  
Elongation Factor ◽  
Young Rats ◽  
Elongation Factor 2 ◽  
And Oxidative Stress

Effect of oxidative stress on in vivo ADP-ribosylation of eukaryotic elongation factor 2

2005 ◽  
Vol 37 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Muhammet Bektaş ◽  
Handan Akçakaya ◽  
Aysin Aroymak ◽  
Rüstem Nurten ◽  
Engin Bermek
Keyword(s):  
Oxidative Stress ◽  
Elongation Factor ◽  
Adp Ribosylation ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

Naringenin ameliorates renal and platelet purinergic signalling alterations in high-cholesterol fed rats through the suppression of ROS and NF-κB signaling pathways

2016 ◽  
Vol 7 (1) ◽  
pp. 183-193 ◽  
Author(s):  
Yassine Chtourou ◽  
Zeineb Kamoun ◽  
Wissem Zarrouk ◽  
Mohammed Kebieche ◽  
Choumous Kallel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Mitochondrial Dysfunction ◽  
Renal Tissue ◽  
Purinergic Signalling ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Flavonoid Aglycone ◽  
And Oxidative Stress

The in vivo protective effect of Naringenin (NGEN), a natural flavonoid aglycone of naringin, against the mitochondrial dysfunction and oxidative stress induced by high cholesterol levels in the renal tissue.

Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis

2011 ◽  
Vol 132 (1-2) ◽  
pp. 55-64 ◽  
Author(s):  
Sandro Argüelles ◽  
Mercedes Cano ◽  
Alberto Machado ◽  
Antonio Ayala
Keyword(s):  
Oxidative Stress ◽  
Elongation Factor ◽  
Elongation Factor 2 ◽  
And Oxidative Stress

‘In vitro’ Protective Effect of a Hydrophilic Vitamin E Analogue on the Decrease in Levels of Elongation Factor 2 in Conditions of Oxidative Stress

Gerontology ◽  
2007 ◽  
Vol 53 (5) ◽  
pp. 282-288 ◽  
Author(s):  
Sandro Argüelles ◽  
Alberto Machado ◽  
Antonio Ayala
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Protective Effect ◽  
Elongation Factor ◽  
Elongation Factor 2

Protective effect of tomato against N-methyl-N′-nitro-N-nitrosoguanidine–induced in vivo clastogenicity and oxidative stress

Nutrition ◽  
2004 ◽  
Vol 20 (9) ◽  
pp. 812-816 ◽  
Author(s):  
Balaiya Velmurugan ◽  
Vaidhyanathan Bhuvaneswari ◽  
Suresh K. Abraham ◽  
Siddavaram Nagini
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
And Oxidative Stress

miR-187 Modulates Cardiomyocyte Apoptosis and Oxidative Stress in Myocardial Infarction Mice via Negatively Regulating DYRK2

2021 ◽  
Author(s):  
Fen Zhu ◽  
Zhili Yu ◽  
Dongsheng Li
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Protective Effect ◽  
Ischemia Reperfusion ◽  
Annexin V ◽  
Cardiomyocyte Apoptosis ◽  
Ros Generation ◽  
And Oxidative Stress

Abstract Background: Myocardial infarction is a serious representation of cardiovescular disease, however, ischemia–reperfusion (I/R) injury is an unpredictable complication of cardiovascular surgeries.Methods: MiR-187 or DYRK2 was inhibited or overexpressed in cardiomyocytes H/R models by pretreatment with miR-187 mimic or inhibitor or DYRK2 inhibitor to confirm the function of miR-187 in H/R. A myocardium I/R mouse model was established using miR-187 transgenic mice. Circulating levels of miR-187 or DYRK2 was detected by quantitative realtime PCR and protein expression was detected by western blotting. The cell viability in all groups was determined by MTT assay and the apoptosis ratio was detected by flow cytometry after staining with Annexin V-FITC. The effect of miR-187 on cellular ROS generation was examined by DCFH-DA. The level of lipid peroxidation and SOD expression were determined by MDA and SOD assay. Results: The findings indicated that miR-187 may be a possible regulator in the protective effect of H/R-induced cardiomyocyte apoptosis, cellular oxidative stress and leaded to DYRK2 suppression at a posttranscriptional level. Moreover, the improvement of miR-187 on H/R-induced cardiomyocyte injury contributed to the obstruction of DYRK2 expression. In addition, these results identified DYRK2 as the functional downstream target of miR-187 regulated myocardial infarction and oxidative stress. Conclusions: These present work provided the first insight into the function of miR-187 in successfully protect cardiomyocyte both in vivo and in vitro, and such a protective effect were mediated through the regulation of DYRK2 expression. Trial registration: Not Applicable.

scholarly journals Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer’s Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Nesrine S. El Sayed ◽  
Mamdooh H. Ghoneum
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Protective Effect ◽  
Cognitive Dysfunction ◽  
Protective Role ◽  
Sporadic Alzheimer’S Disease ◽  
Stat3 Pathway ◽  
And Oxidative Stress

Background. Many neurodegenerative diseases such as Alzheimer’s disease are associated with oxidative stress. Therefore, antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases. Objective. We investigated the ability of the antioxidant Antia to exert a protective effect against sporadic Alzheimer’s disease (SAD) induced in mice. Antia is a natural product that is extracted from the edible yamabushitake mushroom, the gotsukora and kothala himbutu plants, diosgenin (an extract from wild yam tubers), and amla (Indian gooseberry) after treatment with MRN-100. Methods. Single intracerebroventricular (ICV) injection of streptozotocin (STZ) (3 mg/kg) was used for induction of SAD in mice. Antia was injected intraperitoneally (i.p.) in 3 doses (25, 50, and 100 mg/kg/day) for 21 days. Neurobehavioral tests were conducted within 24 h after the last day of injection. Afterwards, mice were sacrificed and their hippocampi were rapidly excised, weighed, and homogenized to be used for measuring biochemical parameters. Results. Treatment with Antia significantly improved mice performance in the Morris water maze. In addition, biochemical analysis showed that Antia exerted a protective effect for several compounds, including GSH, MDA, NF-κB, IL-6, TNF-α, and amyloid β. Further studies with western blot showed the protective effect of Antia for the JAK2/STAT3 pathway. Conclusions. Antia exerts a significant protection against cognitive dysfunction induced by ICV-STZ injection. This effect is achieved through targeting of the amyloidogenic, inflammatory, and oxidative stress pathways. The JAK2/STAT3 pathway plays a protective role for neuroinflammatory and neurodegenerative diseases such as SAD.

scholarly journals Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach

2021 ◽  
Vol 186 ◽  
pp. 114490
Author(s):  
Karuppusamy Arunachalam ◽  
Amilcar Sabino Damazo ◽  
Antonio Macho ◽  
Monica Steffi Matchado ◽  
Eduarda Pavan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
In Silico ◽  
And Oxidative Stress
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