A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

2017 ◽  
Vol 118 (12) ◽  
pp. 4672-4685 ◽  
Author(s):  
Jin Han Nam ◽  
Hyun-Ji Cho ◽  
Hyejin Kang ◽  
Ju-Young Lee ◽  
Mira Jung ◽  
...  
Keyword(s):  
Cell Migration ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Cell Migration And Invasion ◽  
Stat3 Signaling ◽  
Deacetylase Inhibitor

scholarly journals Novel histone deacetylase inhibitor N25 exerts anti-tumor effects and induces autophagy in human glioma cells by inhibiting HDAC3

Oncotarget ◽  
2017 ◽  
Vol 8 (43) ◽  
pp. 75232-75242 ◽  
Author(s):  
Xin-Yuan Sun ◽  
Yue Qu ◽  
An-Ran Ni ◽  
Gui-Xiang Wang ◽  
Wei-Bin Huang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Deacetylase Inhibitor

scholarly journals M2 macrophage-derived exosomal microRNAs inhibit cell migration and invasion in gliomas through PI3K/AKT/mTOR signaling pathway

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jie Yao ◽  
Zefen Wang ◽  
Yong Cheng ◽  
Chao Ma ◽  
Yahua Zhong ◽  
...  
Keyword(s):  
Cell Migration ◽  
Western Blot ◽  
Signaling Pathway ◽  
Target Gene ◽  
Glioma Cells ◽  
Mtor Signaling ◽  
Migration And Invasion ◽  
M2 Macrophage ◽  
Mtor Signaling Pathway ◽  
Cell Migration And Invasion

Abstract Background Glioma, the most common primary brain tumor, account Preparing figures for 30 to 40% of all intracranial tumors. Herein, we aimed to study the effects of M2 macrophage-derived exosomal microRNAs (miRNAs) on glioma cells. Methods First, we identified seven differentially expressed miRNAs in infiltrating macrophages and detected the expression of these seven miRNAs in M2 macrophages. We then selected hsa-miR-15a-5p (miR-15a) and hsa-miR-92a-3p (miR-92a) for follow-up studies, and confirmed that miR-15a and miR-92a were under-expressed in M2 macrophage exosomes. Subsequently, we demonstrated that M2 macrophage-derived exosomes promoted migration and invasion of glioma cells, while exosomal miR-15a and miR-92a had the opposite effects on glioma cells. Next, we performed the target gene prediction in four databases and conducted target gene validation by qRT-PCR, western blot and dual luciferase reporter gene assays. Results The results revealed that miR-15a and miR-92a were bound to CCND1 and RAP1B, respectively. Western blot assays demonstrated that interference with the expression of CCND1 or RAP1B reduced the phosphorylation level of AKT and mTOR, indicating that both CCND1 and RAP1B can activate the PI3K/AKT/mTOR signaling pathway. Conclusion Collectively, these findings indicate that M2 macrophage-derived exosomal miR-15a and miR-92a inhibit cell migration and invasion of glioma cells through PI3K/AKT/mTOR signaling pathway.

Knockdown of long non-coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR-34a

2017 ◽  
Vol 119 (3) ◽  
pp. 2708-2718 ◽  
Author(s):  
Xuechao Dong ◽  
Zheng Jin ◽  
Yong Chen ◽  
Haiyang Xu ◽  
Chengyuan Ma ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals TMEM119 promotes gastric cancer cell migration and invasion through STAT3 signaling pathway

2018 ◽  
Vol Volume 11 ◽  
pp. 5835-5844 ◽  
Author(s):  
Peifen Zheng ◽  
Weifeng Wang ◽  
Muxi Ji ◽  
Qin Zhu ◽  
Yuliang Feng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway
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