The exchange of potassium in frog nerve: Role of aerobic metabolism and glycolysis

1957 ◽  
Vol 49 (2) ◽  
pp. 261-280
Author(s):  
Rose Robyns Coelho
Keyword(s):  
Aerobic Metabolism

The role of aerobic metabolism and intragel oxygen in hypoxia tolerance of three ctenophores: Pleurobrachia bachei, Bolinopsis infundibulum and Mnemiopsis leidyi

2005 ◽  
Vol 85 (3) ◽  
pp. 627-633 ◽  
Author(s):  
Erik V. Thuesen ◽  
Ladd D. Rutherford ◽  
Patricia L. Brommer
Keyword(s):  
Aerobic Metabolism ◽  
Hypoxia Tolerance ◽  
Mnemiopsis Leidyi ◽  
Survival Times ◽  
Partial Pressures ◽  
Pleurobrachia Bachei ◽  
Oxygen Measurements ◽  
Surrounding Seawater ◽  
Planktonic Communities

Ctenophores are important members of planktonic communities that are often abundant in dysaerobic environments. Previous studies have shown that ctenophores are not adversely affected by extended periods of hypoxia. The three species used in this study, Pleurobrachia bachei, Bolinopsis infundibulum, and Mnemiopsis leidyi, were all able to oxyregulate to very low partial pressures of oxygen (PO2s). These species were found to have mean critical oxygen tensions of 7.7, 10.6, and 7.2 hPa respectively. In general, ctenophores are better oxyregulators than medusae and many species of shrimps, fish and squid. Intragel oxygen was measured using a fibre optic oxygen optode. All these ctenophores have intragel subsurface [O2]s of 5–10% below that of the surrounding seawater. Intragel oxygen measurements of P. bachei showed a gradient of decreasing PO2 from surface tissues to the gut. Specimens of P. bachei over 14 mm in diameter had anaerobic guts. Survival times in anoxia ranged from 0 h for M. leidyi to up to 6 h for P. bachei. Ctenophores rely on aerobic metabolism to tolerate hypoxia.

The importance of limitations in aerobic metabolism, glycolysis, and membrane excitability for the development of high-frequency fatigue in isolated rat soleus muscle

2007 ◽  
Vol 292 (5) ◽  
pp. R2001-R2011 ◽  
Author(s):  
K. T. Murphy ◽  
T. Clausen
Keyword(s):  
Soleus Muscle ◽  
High Frequency ◽  
Receptor Agonist ◽  
Aerobic Metabolism ◽  
Membrane Excitability ◽  
M Wave ◽  
Force Transducers ◽  
Rat Soleus Muscle ◽  
Isolated Rat

We investigated the role of limitations in aerobic metabolism, glycolysis, and membrane excitability for development of high-frequency fatigue in isolated rat soleus muscle. Muscles mounted on force transducers were incubated in buffer bubbled with 5% CO2 and either 95% O2 (oxygenated) or 95% N2 (anoxic) and stimulated at 60 Hz continuously for 30–120 s or intermittently for 120 s. Cyanide (2 mM) and 2-deoxyglucose (10 mM) were used to inhibit aerobic metabolism and both glycolysis and aerobic metabolism, respectively. Excitability was reduced by carbacholine (10 μM), a nicotinic ACh receptor agonist, or ouabain (10 μM), an Na+-K+ pump inhibitor. Membrane excitability was measured by recording M waves. Intracellular Na+ and K+ contents and membrane potentials were measured by flame photometry and microelectrodes, respectively. During 120 s of continuous stimulation, oxygenated and anoxic muscles showed the same force loss. In oxygenated muscles, cyanide did not alter force loss for up to 90 s, whereas 2-deoxyglucose increased force loss (by 19–69%; P < 0.01) from 14 s of stimulation. In oxygenated muscles, 60 s of stimulation reduced force, M wave area, and amplitude by 70–90% ( P < 0.001). Carbacholine or ouabain increased intracellular Na+ content ( P < 0.001), induced a 7- to 8-mV membrane depolarization ( P < 0.001), and accelerated the rate of force loss (by 250–414%) during 30 s of stimulation ( P < 0.001). Similar effects were seen with intermittent stimulation. In conclusion, limitations in glycolysis and subsequently also in aerobic metabolism, as well as membrane excitability but not aerobic metabolism alone, appear to play an important role in the development of high-frequency fatigue in isolated rat soleus muscle.

scholarly journals The Influence of Statins on the Aerobic Metabolism of Endothelial Cells

2020 ◽  
Vol 21 (4) ◽  
pp. 1485 ◽  
Author(s):  
Izabela Broniarek ◽  
Karolina Dominiak ◽  
Lukasz Galganski ◽  
Wieslawa Jarmuszkiewicz
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Aerobic Metabolism ◽  
Complex Iii ◽  
Ros Production ◽  
Mitochondrial Ros ◽  
Ros Formation ◽  
Umbilical Vein Endothelial Cells ◽  
Induced Changes

Endothelial mitochondrial dysfunction is considered to be the main cause of cardiovascular disease. The aim of this research was to elucidate the effects of cholesterol-lowering statins on the aerobic metabolism of endothelial cells at the cellular and mitochondrial levels. In human umbilical vein endothelial cells (EA.hy926), six days of exposure to 100 nM atorvastatin (ATOR) induced a general decrease in mitochondrial respiration. No changes in mitochondrial biogenesis, cell viability, or ATP levels were observed, whereas a decrease in Coenzyme Q10 (Q10) content was accompanied by an increase in intracellular reactive oxygen species (ROS) production, although mitochondrial ROS production remained unchanged. The changes caused by 100 nM pravastatin were smaller than those caused by ATOR. The ATOR-induced changes at the respiratory chain level promoted increased mitochondrial ROS production. In addition to the reduced level of mitochondrial Q10, the activity of Complex III was decreased, and the amount of Complex III in a supercomplex with Complex IV was diminished. These changes may cause the observed decrease in mitochondrial membrane potential and an increase in Q10 reduction level as a consequence, leading to elevated mitochondrial ROS formation. The above observations highlight the role of endothelial mitochondria in response to potential metabolic adaptations related to the chronic exposure of endothelial cells to statins.

scholarly journals Seagrass habitat metabolism increases short-term extremes and long-term offset of CO2 under future ocean acidification

2018 ◽  
Vol 115 (15) ◽  
pp. 3870-3875 ◽  
Author(s):  
Stephen R. Pacella ◽  
Cheryl A. Brown ◽  
George G. Waldbusser ◽  
Rochelle G. Labiosa ◽  
Burke Hales
Keyword(s):  
Ocean Acidification ◽  
High Frequency ◽  
Water Quality Management ◽  
Aerobic Metabolism ◽  
Mechanistic Modeling ◽  
Seagrass Habitat ◽  
Carbonate System ◽  
Complex Chemistry

The role of rising atmospheric CO2 in modulating estuarine carbonate system dynamics remains poorly characterized, likely due to myriad processes driving the complex chemistry in these habitats. We reconstructed the full carbonate system of an estuarine seagrass habitat for a summer period of 2.5 months utilizing a combination of time-series observations and mechanistic modeling, and quantified the roles of aerobic metabolism, mixing, and gas exchange in the observed dynamics. The anthropogenic CO2 burden in the habitat was estimated for the years 1765–2100 to quantify changes in observed high-frequency carbonate chemistry dynamics. The addition of anthropogenic CO2 alters the thermodynamic buffer factors (e.g., the Revelle factor) of the carbonate system, decreasing the seagrass habitat’s ability to buffer natural carbonate system fluctuations. As a result, the most harmful carbonate system indices for many estuarine organisms [minimum pHT, minimum Ωarag, and maximum pCO2(s.w.)] change up to 1.8×, 2.3×, and 1.5× more rapidly than the medians for each parameter, respectively. In this system, the relative benefits of the seagrass habitat in locally mitigating ocean acidification increase with the higher atmospheric CO2 levels predicted toward 2100. Presently, however, these mitigating effects are mixed due to intense diel cycling of CO2 driven by aerobic metabolism. This study provides estimates of how high-frequency pHT, Ωarag, and pCO2(s.w.) dynamics are altered by rising atmospheric CO2 in an estuarine habitat, and highlights nonlinear responses of coastal carbonate parameters to ocean acidification relevant for water quality management.

Role of fatty acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise

2006 ◽  
Vol 24 (6) ◽  
pp. 475-481 ◽  
Author(s):  
Sandro M. Hirabara ◽  
Leonardo R. Silveira ◽  
Fernando R. M. Abdulkader ◽  
Luciane C. Alberici ◽  
Joaquim Procopio ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Aerobic Metabolism

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

Elaborating the role of reflection and individual differences in the study of folk-economic beliefs

2018 ◽  
Vol 41 ◽  
Author(s):  
Kevin Arceneaux
Keyword(s):  
Decision Making ◽  
Individual Differences ◽  
Cognitive Processes ◽  
Evolutionary History ◽  
Behavioral Responses ◽  
History Of ◽  
Economic Beliefs

AbstractIntuitions guide decision-making, and looking to the evolutionary history of humans illuminates why some behavioral responses are more intuitive than others. Yet a place remains for cognitive processes to second-guess intuitive responses – that is, to be reflective – and individual differences abound in automatic, intuitive processing as well.

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