Thermal crystallisation of amorphous calcium phosphate to α-tricalcium phosphate

2007 ◽  
Vol 32 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Takafumi Kanazawa ◽  
Takao Umegaki ◽  
Naoki Uchiyama
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate

Synthesis and Properties of α-Tricalcium Phosphate from Amorphous Calcium Phosphate as Component for Bone Cements

2016 ◽  
Vol 721 ◽  
pp. 182-186
Author(s):  
Zilgma Irbe ◽  
Dagnija Loca ◽  
Agnese Pura ◽  
Liga Berzina-Cimdina
Keyword(s):  
Heat Treatment ◽  
Particle Size ◽  
Calcium Phosphate ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Heat Treating ◽  
Bone Cements ◽  
Important Ingredient ◽  
Reactive Particles

α-Tricalcium phosphate is an important ingredient of calcium phosphate bone cements, which are used for bone defect augmentation and repair. In this study sub-micrometre sized α­tricalcium phosphate particles were synthesized by heat treating amorphous calcium phosphate. Size of synthesized particles depended on duration and temperature of heat treatment. Longer duration and higher temperatures produced larger particles. The reactivity of synthesized particles did not correlate with particle size – the smallest particles did not have the highest reactivity. The most reactive particles were prepared at 700-800 °C. The prepared particles were more reactive than those of conventionally synthesized α-tricalcium phosphate.

In Vitro Dissolution Behavior of Biphasic Tricalcium Phosphate Composite Powders Composed of α-Tricalcium Phosphate and β-Tricalcium Phosphate

2008 ◽  
Vol 368-372 ◽  
pp. 1206-1208 ◽  
Author(s):  
Yan Bao Li ◽  
Dong Xu Li ◽  
Wen Jian Weng
Keyword(s):  
Heat Treatment ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Ph Value ◽  
In Vitro Dissolution ◽  
Dissolution Behavior ◽  
Buffer Solution ◽  
Composite Powders

Biphasic tricalcium phosphate (BTCP) powders composed of α-tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP) were prepared using amorphous calcium phosphate (ACP) precursor after heat treatment at 800oC. The in vitro dissolution behavior of the powders was examined after soaked in 0.1M NaAc-HAc buffer solution for different times. It was revealed that the Ca2+ and PO4 3- concentration, and pH value of the BTCP-soaked solution are higher than those of the α-TCP- and β-TCP-soaked solutions. The dissolution behavior of BTCP powders was explained. The specific dissolution behavior of BTCP powders can widen the biodegradation range of calcium phosphate family.

scholarly journals Enamel remineralisation-inducing materials for caries prevention

2021 ◽  
Vol 54 (3) ◽  
pp. 165
Author(s):  
Sri Kunarti ◽  
Widya Saraswati ◽  
Dur Muhammad Lashari ◽  
Nadhifa Salma ◽  
Tasya Nafatila
Keyword(s):  
Calcium Phosphate ◽  
Dental Caries ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Caries Prevention ◽  
Multifactorial Disease ◽  
Dental Tissue ◽  
Carious Lesions ◽  
Caries Management ◽  
Casein Phosphopeptide

Background: Dental caries is a multifactorial disease indicated by the progressive demineralisation process of dental tissue. It is caused by an imbalance between the remineralisation and demineralisation processes. The focus of caries management is on prevention. Providing materials that can induce remineralisation is one management of caries prevention. Various materials have been or are being researched, such as casein phosphopeptide amorphous calcium phosphate (CPP–ACP), tricalcium phosphate (fTCP), bioactive glass (BAG), and nanotechnologies such as nano-hydroxyapatite (n-HAP) and silver nano fluorine (NSF). Purpose: This study aims to review the development of enamel remineralisation inducing materials as a newer approach in caries prevention. Review: Various ingredients have been shown to increase enamel remineralisation through different mechanisms in preventing the development of carious lesions. Conclusion: CPP–ACP, fTCP, BAG, n-HAP, and NSF can induce enamel remineralisation as caries prevention agents. n-HAP and NSF are the most effective agents to enhance enamel remineralisation to prevent caries.

Synthesis of Amorphous Calcium Phosphate as a Starting Material for α-Tricalcium Phosphate

2017 ◽  
Vol 267 ◽  
pp. 119-123
Author(s):  
Zilgma Irbe ◽  
Armands Buss ◽  
Dagnija Loca ◽  
Lasma Malniece
Keyword(s):  
Calcium Phosphate ◽  
Sodium Hydroxide ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Ion Concentration ◽  
Bone Tissue Regeneration ◽  
Content Increase ◽  
Reactive Component ◽  
Aqueous Synthesis ◽  
The Stability

α-Tricalcium phosphate (α-TCP) is an important reactive component in calcium phosphate bone cements which are used for the bone tissue regeneration and augmentation. By thermally treating amorphous calcium phosphate (ACP) at relatively low temperatures (650–900 °C), it is possible to obtain sub-micrometre or nanosized α-TCP particles. In the current research, it is shown that the aqueous synthesis environment where ACP is precipitated has significant influence on the stability of ACP and the α-TCP content in the thermally treated products. During ACP synthesis pH must be kept basic. While it is possible to synthesize ACP if potassium hydroxide or sodium hydroxide is used to raise the pH of synthesis, ammonium ions also must be present in the solution to obtain α-TCP after thermal treatment of ACP. If sodium hydroxide is used, higher α-TCP content is obtained (compare 89 % and 66 %). Increase of Ca/P ratio stabilizes ACP and allows to obtain products with high α-TCP content. Increase of both calcium and phosphate ion concentration in the synthesis destabilizes ACP and reduces the amount of α-TCP in the product (twofold increase reduced α-TCP content from 89% to 2%).

scholarly journals Nanocomposites based on apatitic tricalcium phosphate and autofibrin

2021 ◽  
Vol 57 (4) ◽  
pp. 413-423
Author(s):  
I. E. Glazov ◽  
V. K. Krut’ko ◽  
R. A. Vlasov ◽  
O. N. Musskaya ◽  
A. I. Kulak
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Calcium Phosphates ◽  
Fibrin Clot ◽  
Combined Effect ◽  
Morphological Properties ◽  
Maturation Time ◽  
Soluble Calcium

Nanocomposites based on apatitic tricalcium phosphate in an autofibrin matrix were obtained by precipitation at a Ca/P ratio of 1.50, pH 9 and a maturation time from 30 min to 7–14 days. The resorbability of nanocomposites was determined by the composition of calcium phosphates, which, during long-term maturation, formed as the calcium-deficient hydroxyapatite with a Ca/P ratio of 1.66, whereas biopolymer matrix favored the formation of more soluble calcium phosphates with a Ca/P ratio of 1.53–1.59. It was found that the fibrin clot stabilized, along with apatitic tricalcium phosphate, the phase of amorphous calcium phosphate, which after 800 °C was transformed into resorbable α-tricalcium phosphate. Citrated plasma inhibited the conversion of apatitic tricalcium phosphate into stoichiometric hydroxyapatite, which also facilitated the formation of resorbable β-tricalcium phosphate after 800 °C. The combined effect of the maturation time and the biopolymer matrix determined the composition, physicochemical and morphological properties of nanocomposites and the possibililty to control its extent of resorption

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