scholarly journals Travelling-wave ion mobility and negative ion fragmentation of high-mannoseN-glycans

2016 ◽  
Vol 51 (3) ◽  
pp. 219-235 ◽  
Author(s):  
David J. Harvey ◽  
Charlotte A. Scarff ◽  
Matthew Edgeworth ◽  
Weston B. Struwe ◽  
Kevin Pagel ◽  
...  
Keyword(s):  
Ion Mobility ◽  
Travelling Wave ◽  
Negative Ion ◽  
Ion Fragmentation

scholarly journals Identification of N-glycans with GalNAc-containing antennae from recombinant HIV trimers by ion mobility and negative ion fragmentation

2021 ◽  
Author(s):  
David J. Harvey ◽  
Anna-Janina Behrens ◽  
Max Crispin ◽  
Weston B. Struwe
Keyword(s):  
Cross Sections ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Negative Ion ◽  
Ion Fragmentation ◽  
Structural Identity ◽  
Immunodeficiency Virus ◽  
Different Types ◽  
Complex Glycans ◽  
Ion Collision

AbstractNegative ion collision-induced dissociation (CID) of underivatized N-glycans has proved to be a simple, yet powerful method for their structural determination. Recently, we have identified a series of such structures with GalNAc rather than the more common galactose capping the antennae of hybrid and complex glycans. As part of a series of publications describing the negative ion fragmentation of different types of N-glycan, this paper describes their CID spectra and estimated nitrogen cross sections recorded by travelling wave ion mobility mass spectrometry (TWIMS). Most of the glycans were derived from the recombinant glycoproteins gp120 and gp41 from the human immunodeficiency virus (HIV), recombinantly derived from human embryonic kidney (HEK 293T) cells. Twenty-six GalNAc-capped hybrid and complex N-glycans were identified by a combination of TWIMS, negative ion CID, and exoglycosidase digestions. They were present as the neutral glycans and their sulfated and α2→3-linked sialylated analogues. Overall, negative ion fragmentation of glycans generates fingerprints that reveal their structural identity.

scholarly journals Travelling-wave ion mobility mass spectrometry and negative ion fragmentation of hybrid and complexN-glycans

2016 ◽  
Vol 51 (11) ◽  
pp. 1064-1079 ◽  
Author(s):  
David J. Harvey ◽  
Charlotte A. Scarff ◽  
Matthew Edgeworth ◽  
Kevin Pagel ◽  
Konstantinos Thalassinos ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Negative Ion ◽  
Ion Mobility Mass Spectrometry ◽  
Ion Fragmentation

Travelling wave ion mobility and negative ion fragmentation for the structural determination ofN-linked glycans

2013 ◽  
Vol 34 (16) ◽  
pp. 2368-2378 ◽  
Author(s):  
David J. Harvey ◽  
Charlotte A. Scarff ◽  
Matthew Edgeworth ◽  
Max Crispin ◽  
Christopher N. Scanlan ◽  
...  
Keyword(s):  
Ion Mobility ◽  
Travelling Wave ◽  
Negative Ion ◽  
Structural Determination ◽  
Ion Fragmentation

scholarly journals Amphitrite: A program for processing travelling wave ion mobility mass spectrometry data

2013 ◽  
Vol 345-347 ◽  
pp. 54-62 ◽  
Author(s):  
Ganesh N. Sivalingam ◽  
Jun Yan ◽  
Harpal Sahota ◽  
Konstantinos Thalassinos
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Mass Spectrometry Data ◽  
Ion Mobility Mass Spectrometry

scholarly journals Fast Sensing of Hydrogen Cyanide (HCN) Vapors Using a Hand-Held Ion Mobility Spectrometer with Nonradioactive Ionization Source

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5045
Author(s):  
Victor Bocos-Bintintan ◽  
Ileana Andreea Ratiu
Keyword(s):  
Ion Mobility ◽  
Hydrogen Cyanide ◽  
Limit Of Detection ◽  
Chemical Warfare Agent ◽  
Source Model ◽  
Negative Ion ◽  
Industrial Chemicals ◽  
Ionization Source ◽  
Toxic Industrial Chemicals ◽  
Negative Ion Mode

Sensitive real-time detection of vapors produced by toxic industrial chemicals (TICs) always represents a stringent priority. Hydrogen cyanide (HCN) is definitely a TIC, being widely used in various industries and as an insecticide; it is a reactive, very flammable, and highly toxic compound that affects the central nervous system, cardiovascular system, eyes, nose, throat, and also has systemic effects. Moreover, HCN is considered a blood chemical warfare agent. This study was focused toward quick detection and quantification of HCN in air using time-of-flight ion mobility spectrometry (ToF IMS). Results obtained clearly indicate that IMS can rapidly detect HCN at sub-ppmv levels in air. Ion mobility spectrometric response was obtained in the negative ion mode and presented one single distinct product ion, at reduced ion mobility K0 of 2.38 cm2 V−1 s−1. Our study demonstrated that by using a miniaturized commercial IMS system with nonradioactive ionization source model LCD-3.2E (Smiths Detection Ltd., London, UK), one can easily measure HCN at concentrations of 0.1 ppmv (0.11 mg m−3) in negative ion mode, which is far below the OSHA PEL-TWA value of 10 ppmv. Measurement range was from 0.1 to 10 ppmv and the estimated limit of detection LoD was ca. 20 ppbv (0.02 mg m−3).

Flow‐drift technique for ion mobility and ion‐molecule reaction rate constant measurements. III. Negative ion reactions of O− with CO, NO, H2, and D2

1973 ◽  
Vol 59 (12) ◽  
pp. 6629-6635 ◽  
Author(s):  
M. McFarland ◽  
D. L. Albritton ◽  
F. C. Fehsenfeld ◽  
E. E. Ferguson ◽  
A. L. Schmeltekopf
Keyword(s):  
Rate Constant ◽  
Ion Mobility ◽  
Reaction Rate ◽  
Reaction Rate Constant ◽  
Negative Ion ◽  
Molecule Reaction

scholarly journals Distinguishing between halogenated alkanes containing the same halogen based on the reaction kinetic parameter using negative ion mobility spectrometry at atmospheric pressure

RSC Advances ◽  
2020 ◽  
Vol 10 (49) ◽  
pp. 29441-29449
Author(s):  
Haiyan Han ◽  
Shihu Du ◽  
Yongliang Yan ◽  
Xiuhong Liu ◽  
Qiaofen Zhu ◽  
...  
Keyword(s):  
Kinetic Parameter ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Atmospheric Pressure ◽  
Reaction Kinetic ◽  
Electron Attachment ◽  
High Sensitivity ◽  
Negative Ion ◽  
Volatile Organic ◽  
Halogenated Alkanes

Electron attachment ionization ion mobility spectrometry can be used to detect halogen-containing volatile organic compounds with high sensitivity.

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