scholarly journals Amino acid concentrations in the hamster central auditory system and long-term effects of intense tone exposure

2012 ◽  
Vol 90 (11) ◽  
pp. 2214-2224 ◽  
Author(s):  
Donald A. Godfrey ◽  
James A. Kaltenbach ◽  
Kejian Chen ◽  
Omer Ilyas ◽  
Xiaochen Liu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Auditory System ◽  
Central Auditory System ◽  
Long Term Effects ◽  
Amino Acid Concentrations

Effects of early-and mid-pregnancy under-nutrition on maternal and foetal plasma free amino acid concentrations in Scottish Blackface and Suffolk sheep

2009 ◽  
Vol 2009 ◽  
pp. 74-74
Author(s):  
J A Rooke ◽  
M Werkman ◽  
K McIlvaney ◽  
C M Dwyer ◽  
C J Ashworth
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Nutrient Intake ◽  
Tissue Growth ◽  
Long Term Effects ◽  
Lean Tissue ◽  
Foetal Development ◽  
Under Nutrition ◽  
Amino Acid Concentrations

Nutrient intake during pregnancy affects foetal development and placental function in a range of species, often with long-term effects on offspring viability. Maternal supply and placental transport of amino acids are key to delivering amino acids for foetal metabolism. Maternal under-nutrition has been shown to reduce both maternal and foetal amino acid concentrations even after a period of re-feeding (Kwon et al. 2004). Intriguingly whether sheep have been adapted to a harsh environment or not appears to influence the extent of any reduction (Jobgen et al. 2008). The present study therefore tested whether plasma amino acid concentrations differed between Scottish Blackface (B) sheep adapted to a hill environment and a lowland breed (Suffolk, S) selected for lean tissue growth when challenged by a period of under-nutrition.

Long-Term Voluntary Fasting in Adult Obese Cats: Nitrogen Balance, Plasma Amino Acid Concentrations and Urinary Orotic Acid Excretion

1994 ◽  
Vol 124 (suppl_12) ◽  
pp. 2680S-2682S ◽  
Author(s):  
Vincent Biourge ◽  
Joseph M. Groff ◽  
James G. Morris ◽  
Quinton R. Rogers
Keyword(s):  
Amino Acid ◽  
Nitrogen Balance ◽  
Orotic Acid ◽  
Plasma Amino Acid ◽  
Acid Excretion ◽  
Amino Acid Concentrations

Nitrogen Balance, Plasma Free Amino Acid Concentrations and Urinary Orotic Acid Excretion during Long-Term Fasting in Cats

1994 ◽  
Vol 124 (7) ◽  
pp. 1094-1103 ◽  
Author(s):  
Vincent Biourge ◽  
Joseph M. Groff ◽  
Cindy Fisher ◽  
Deborah Bee ◽  
James G. Morris ◽  
...  
Keyword(s):  
Amino Acid ◽  
Free Amino Acid ◽  
Nitrogen Balance ◽  
Free Amino ◽  
Orotic Acid ◽  
Acid Excretion ◽  
Amino Acid Concentrations

Modification of An Amino Acid Solution for Peritoneal Dialysis to Reduce Risk of Acidemia

1997 ◽  
Vol 17 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Michael Jones ◽  
Roberto Kalil ◽  
Peter Blake ◽  
Leo Martis ◽  
Dimitrios G. Oreopoulos
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Peritoneal Dialysis ◽  
Amino Acid ◽  
Acid Solution ◽  
Long Term Effects ◽  
Amino Acid Solution ◽  
Nutritional Benefits ◽  
Modified Formula

Objective Some patients develop a mild acidemia during treatment with amino acid-based peritoneal dialysis solutions due to hydrogen ion produced by metabolism of lysine, arginine, and methionine. In this study we modified the formulation of such a solution by reducing these amino acids and adding anionic amino acids so as to provide minimal net acid production. Design A modified formula (MF) was compared to a conventional formula (CF) of the solution in a randomized crossover study in 12 stable continuous ambulatory peritoneal dialysis patients. Patients were given each solution for 14 days without a wash-out period. Each patient replaced one or two dextrose dialysis exchanges with amino acid solution, depending upon oral protein intake and body weight. Total intake (oral protein plus amino acids absorbed) was equivalent to 1.1 -1.3 g protein/kg body weight/day.Plasma bicarbonate and urea were assessed at the beginning and end of each 14-day period. Results In the group as a whole, without regard to the order in which the solutions were given, patients had a decrease in serum bicarbonate with CF and an increase in bicarbonate when they received MF. Similar trends were observed regardless of the order in which the solutions were administered. Serum urea did not differ between the two solutions. Conclusion The results suggest that patients are less prone to develop acidemia when receiving MF as opposed to CF. Further studies will be necessary to determine the long-term effects and the relative nutritional benefits of the two solutions.

Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats

2017 ◽  
Vol 350 ◽  
pp. 173-188 ◽  
Author(s):  
Donald A. Godfrey ◽  
Kejian Chen ◽  
Thomas R. O'Toole ◽  
Abdurrahman I.A.A. Mustapha
Keyword(s):  
Amino Acid ◽  
Auditory System ◽  
Central Auditory System ◽  
Middle Aged ◽  
Old Rats

scholarly journals A systematic review of mercury ototoxicity

2012 ◽  
Vol 28 (7) ◽  
pp. 1239-1248 ◽  
Author(s):  
Ana Cristina Hiromi Hoshino ◽  
Heloisa Pacheco Ferreira ◽  
Olaf Malm ◽  
Renata Mamede Carvallo ◽  
Volney Magalhães Câmara
Keyword(s):  
Systematic Review ◽  
Auditory System ◽  
Chemical Substance ◽  
Mercury Exposure ◽  
Central Auditory System ◽  
Inclusion Criteria ◽  
Irreversible Damage ◽  
The Relationship

Mercury is neurotoxic, and numerous studies have confirmed its ototoxic effect. However, the diagnosis and follow-up of mercury exposure require understanding the pathophysiology of the chemical substance. Based on a systematic literature review, this study aimed to demonstrate whether mercury is ototoxic and to analyze its mechanism of action on the peripheral and central auditory system, in order to contribute to the diagnosis and follow-up of exposure. This was a systematic review of studies published on the effects of mercury exposure on the auditory system. The full text of the studies and their methodological quality were analyzed. The review identified 108 studies published on the theme, of which 28 met the inclusion criteria. All the articles in the analysis showed that mercury exposure is ototoxic and produces peripheral and/or central damage. Acute and long-term exposure produces irreversible damage to the central auditory system. Biomarkers were unable to predict the relationship between degree of mercury poisoning and degree of lesion in the auditory system.

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