Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungoin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice

1986 ◽  
Vol 16 (2) ◽  
pp. 367-376 ◽  
Author(s):  
S.G. Amur ◽  
G. Shanker ◽  
J.M. Cochran ◽  
H.S. Ved ◽  
R.A. Pieringer
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein ◽  
Protein Arginine Methyltransferase ◽  
Arginine Methyltransferase ◽  
Myelin Formation

scholarly journals Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice.

1989 ◽  
Vol 86 (14) ◽  
pp. 5661-5665 ◽  
Author(s):  
M. Kimura ◽  
M. Sato ◽  
A. Akatsuka ◽  
S. Nozawa-Kimura ◽  
R. Takahashi ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein ◽  
Single Type ◽  
Myelin Formation

Transcription of myelin basic protein promoted by regulatory elements in the proximal 5’ sequence requires myelinogenesis

1996 ◽  
Vol 2 (3) ◽  
pp. 125-132 ◽  
Author(s):  
B Stankoff ◽  
C Demerens ◽  
C Goujet-Zalc ◽  
M Monge ◽  
F Peyron ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Reporter Gene ◽  
Transcriptional Activation ◽  
Basic Protein ◽  
Transgenic Animals ◽  
Promoter Sequence ◽  
Regulatory Elements ◽  
Myelin Proteins ◽  
Proximal Promoter ◽  
Myelin Formation

Myelination in the central nervous system requires synthesis by oligodendrocytes of enormous amounts of lipids and proteins for incorporation in the developing myelin membranes. To approach the regulatory events coordinating the transcriptional activation of the genes that encode myelin proteins, we examined control of the myelin basic protein (MBP) locus. MBP plays a major role in myelin compaction. During development, MBP is already expressed in mature non-myelinating oligodendrocytes. Here we show that, in transgenic animals in which the E. coli lacZ reporter gene is under the control of increasingly large portions (256, 1900 and 3200 bp) of the MBP promoter, 5’ of the initiation of transcription site, reporter gene expression was initiated after myelin formation had started. This delayed expression of the transgene compared to MBP, strongly suggests that premyelinating expression is dependent on regulatory elements located outside of the 3200 bp sequence studied, while expression occurring at the time of myelin formation is dependent on the proximal promoter sequence.

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