scholarly journals Bisphosphonate‐induced reactive oxygen species inhibit proliferation and migration of oral fibroblasts: A pathogenesis of bisphosphonate‐related osteonecrosis of the jaw

2020 ◽  
Vol 91 (7) ◽  
pp. 947-955
Author(s):  
Naomi Taniguchi ◽  
Mitsuhiko Osaki ◽  
Kunishige Onuma ◽  
Mizuho Ishikawa ◽  
Kazuo Ryoke ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Osteonecrosis Of The Jaw ◽  
Oxygen Species ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

2009 ◽  
Vol 11 (4) ◽  
pp. 747-764 ◽  
Author(s):  
Srikanth Pendyala ◽  
Irina A Gorshkova ◽  
Peter V. Usatyuk ◽  
Donghong He ◽  
Arjun Pennathur ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Human Lung ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Lung Endothelial Cells ◽  
And Migration

scholarly journals Reactive Oxygen Species as Essential Mediators of Cell Adhesion and Migration

2010 ◽  
Vol 98 (3) ◽  
pp. 576a ◽  
Author(s):  
Giuseppe Maulucci ◽  
Giovambattista Pani ◽  
Valentina Labate ◽  
Marina Mele ◽  
Emiliano Panieri ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Adhesion ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 175 ◽  
Author(s):  
Stefania Fumarola ◽  
Monia Cecati ◽  
Davide Sartini ◽  
Gianna Ferretti ◽  
Giulio Milanese ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Caspase 3 ◽  
Reactive Oxygen ◽  
Caspase 8 ◽  
Activity Levels ◽  
Oxygen Species ◽  
T24 Cells ◽  
Before And After ◽  
And Migration

The goal of the current study was to identify potential roles of paraoxonase-2 in bladder carcinogenesis. T24 bladder cancer cells were transfected with plasmids inducing paraoxonase-2 silencing or overexpression. Upon the selection of clones stably down- or upregulating paraoxonase-2, cell proliferation, migration, and the production of reactive oxygen species were evaluated, before and after treatment with cisplatin and gemcitabine, used alone or in combination. The activity levels of both caspase-3 and caspase-8 were also analyzed. shRNA-mediated gene silencing and the overexpression of paraoxonase-2 revealed that the enzyme was able to promote both the proliferation and migration of T24 cells. Moreover, the knockdown of paraoxonase-2 was significantly associated with a reduced cell viability of T24 cells treated with chemotherapeutic drugs and led to both an increase of reactive oxygen species production and caspase-3 and caspase-8 activation. Conversely, under treatment with anti-neoplastic compounds, a higher proliferative capacity was found in T24 cells overexpressing paraoxonase-2 compared with controls. In addition, upon enzyme upregulation, both the production of reactive oxygen species and activation of caspase-3 and caspase-8 were reduced. Although further analyses will be required to fully understand the involvement of paraoxonase-2 in bladder tumorigenesis and in mechanisms leading to the development of chemoresistance, the data reported in this study seem to demonstrate that the enzyme could exert a great impact on tumor progression and susceptibility to chemotherapy, thus suggesting paraoxonase-2 as a novel and interesting molecular target for effective bladder cancer treatment.

scholarly journals PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species

2015 ◽  
Vol 35 (5) ◽  
Author(s):  
Qingbin Zhao ◽  
Junfang Zhang ◽  
Huifang Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle Cells ◽  
Ros Generation ◽  
Oxygen Species ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

The protein content of PGC-1α was negatively correlated with an increase in cell proliferation and migration induced by AngII. PGC-1α could decrease ROS generation derived from NADPH oxidase induced by AngII, thus attenuating VSMC hyperplasia.

Modulation of Vascular Smooth Muscle Signaling by Reactive Oxygen Species

Physiology ◽  
2006 ◽  
Vol 21 (4) ◽  
pp. 269-280 ◽  
Author(s):  
Alicia N. Lyle ◽  
Kathy K. Griendling
Keyword(s):  
Reactive Oxygen Species ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Signaling Pathways ◽  
Reactive Oxygen ◽  
Cardiovascular Physiology ◽  
Oxygen Species ◽  
Nadph Oxidases ◽  
And Migration ◽  
Intracellular Targets

Modulation of signaling in vascular cells by reactive oxygen species (ROS) affects many aspects of cellular function, including growth, migration, and contraction. NADPH oxidases, important sources of ROS, regulate many growth-specific and migration-related signaling pathways. Identifying the precise intracellular targets of ROS enhances understanding of their role in cardiovascular physiology and pathophysiology.

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