Critical analysis of lymph node examination in patients undergoing curative‐intent resection for adrenocortical carcinoma

2020 ◽  
Vol 122 (6) ◽  
pp. 1152-1162
Author(s):  
Benjamin W. Deschner ◽  
Zachary E. Stiles ◽  
Olivia M. DeLozier ◽  
Justin A. Drake ◽  
Miriam Tsao ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adrenocortical Carcinoma ◽  
Critical Analysis ◽  
Curative Intent ◽  
Lymph Node Examination

scholarly journals Positive lymph node ratio is an index in predicting prognosis for remnant gastric cancer with insufficient retrieved lymph node in R0 resection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Honghu Wang ◽  
Hao Qi ◽  
Xiaofang Liu ◽  
Ziming Gao ◽  
Iko Hidasa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Prognostic Index ◽  
Staging System ◽  
R0 Resection ◽  
Remnant Gastric Cancer ◽  
Curative Intent ◽  
Node Ratio

AbstractThe staging system of remnant gastric cancer (RGC) has not yet been established, with the current staging being based on the guidelines for primary gastric cancer. Often, surgeries for RGC fail to achieve the > 15 lymph nodes needed for TNM staging. Compared with the pN staging system, lymph node ratio (NR) may be more accurate for RGC staging and prognosis prediction. We retrospectively analyzed the data of 208 patients who underwent R0 gastrectomy with curative intent and who have ≤ 15 retrieved lymph nodes (RLNs) for RGC between 2000 and 2014. The patients were divided into four groups on the basis of the NR cutoffs: rN0: 0; rN1: > 0 and ≤ 1/6; rN2: > 1/6 and ≤ 1/2; and rN3: > 1/2. The 5-year overall survival (OS) rates for rN0, rN1, rN2, and rN3 were 84.3%, 64.7%, 31.5%, and 12.7%, respectively. Multivariable analyses revealed that tumor size (p = 0.005), lymphovascular invasion (p = 0.023), and NR (p < 0.001), but not pN stage (p = 0.682), were independent factors for OS. When the RLN count is ≤ 15, the NR is superior to pN as an important and independent prognostic index of RGC, thus predicting the prognosis of RGC patients more accurately.

Outcomes of isolated distant lymph node metastases in colorectal cancer.

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 84-84
Author(s):  
Vinod Kalapurackal Mathai ◽  
Soe Yu Aung ◽  
Vanessa Wong ◽  
Catherine Dunn ◽  
Jeremy David Shapiro ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Locoregional Therapy ◽  
Curative Intent ◽  
Palliative Intent ◽  
Radical Treatment ◽  
Node Metastases ◽  
Systemic Therapies

84 Background: The optimal management of isolated distant lymph node metastases (IDLNM) in metastatic colorectal cancer (mCRC) is not clearly established. Small case series and prior data from the TRACC (Treatment of Recurrent and Advanced Colorectal Cancer) registry support the use of radical treatment with curative intent (local resection, chemo-radiation or stereotactic radiotherapy), which may lead to better outcomes in mCRC patients with IDLNM. Aims: This study investigates the clinical characteristics and outcomes of mCRC patients with IDLNM treated with systemic therapies plus locoregional therapy with curative intent versus systemic therapies with palliative intent. Methods: Clinical data were collected and reviewed from the TRACC registry, a prospective, comprehensive registry for mCRC from multiple tertiary hospitals across Australia from 01/07/2009 to 30/06/2020. Clinicopathological characteristics, treatment modalities and survival outcomes were analyzed in patients with IDLNM and compared to patients with other organ metastases. Fisher exact test was used for significance tests and Kaplan Meier curves for survival analyses. Results: Of 3408 mCRC patients with a median follow-up of 38.0 months, 93 (2.7%) were found to have IDLNM. Compared to mCRC with other organ metastases, patients with IDLNM were younger (mean age: 62.1 vs 65.6 years, p=0.0200), more likely to have metachronous disease (57.0% vs 38.9%, p=0.0005), be KRAS wild-type (74.6% vs 53.9%, p=0.0012) and BRAF mutant (12.9% vs 6.2%, p=0.0100). There was no overall survival difference between with IDLNM and those with other organ metastases (median OS 27.24 vs 25.92 months, p=0.2300). Twenty-four patients (25.8%) with IDLNM received treatment with curative intent, with a trend towards improved overall survival compared to those with other organ metastases treated with curative intent (73.5 vs 62.7 months, p=0.8200). Amongst mCRC patients with IDLNM, those who received treatment with curative intent had a significantly better overall survival than those treated with palliative intent (73.5months vs 23.2 months, p=0.0070). Conclusions: Our findings suggest that there are differences in the patterns of presentation of IDLNM and other organ metastases. Radical treatment with curative intent options should be considered for mCRC patients with IDLNM where appropriate.

Patterns of Lymph Node Recurrence in Adrenocortical Carcinoma: Possible Implications for Primary Surgical Treatment

2018 ◽  
Vol 26 (2) ◽  
pp. 531-538 ◽  
Author(s):  
Joachim Reibetanz ◽  
Britta Rinn ◽  
Andreas S. Kunz ◽  
Sven Flemming ◽  
Cristina L. Ronchi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Adrenocortical Carcinoma ◽  
Lymph Node Recurrence

scholarly journals Early versus deferred androgen suppression therapy for patients with lymph node-positive prostate cancer after local therapy with curative intent: a systematic review

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Frank Kunath ◽  
Bastian Keck ◽  
Gerta Rücker ◽  
Edith Motschall ◽  
Bernd Wullich ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Lymph Node ◽  
Local Therapy ◽  
Curative Intent ◽  
Node Positive ◽  
Androgen Suppression ◽  
Lymph Node Positive

scholarly journals The Methods of Lymph Node Examination Make a Difference to Node Staging and Detection of N3b Node Status for Gastric Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Xinhua Chen ◽  
Yuehong Chen ◽  
Yanfeng Hu ◽  
Tian Lin ◽  
Jun Luo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Node Status ◽  
Lymph Node Examination

Prognostic Performance of Different Lymph Node Staging Systems After Curative Intent Resection for Gastric Adenocarcinoma

2015 ◽  
Vol 262 (6) ◽  
pp. 991-998 ◽  
Author(s):  
Gaya Spolverato ◽  
Aslam Ejaz ◽  
Yuhree Kim ◽  
Malcolm H. Squires ◽  
George Poultsides ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gastric Adenocarcinoma ◽  
Lymph Node Staging ◽  
Curative Intent ◽  
Prognostic Performance ◽  
Staging Systems

Lymph Node Examination Rate, Survival Rate, and Quality of Care in Colon Cancer

JAMA ◽  
2008 ◽  
Vol 299 (8) ◽  
pp. 896 ◽  
Author(s):  
Karl Y. Bilimoria
Keyword(s):  
Colon Cancer ◽  
Quality Of Care ◽  
Lymph Node ◽  
Survival Rate ◽  
Lymph Node Examination

scholarly journals Use of a Surgical Specimen-Collection Kit to Improve Mediastinal Lymph-Node Examination of Resectable Lung Cancer

2012 ◽  
Vol 7 (8) ◽  
pp. 1276-1282 ◽  
Author(s):  
Raymond U. Osarogiagbon ◽  
Laura E. Miller ◽  
Robert A. Ramirez ◽  
Christopher G. Wang ◽  
Thomas F. O’Brien ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Mediastinal Lymph Node ◽  
Surgical Specimen ◽  
Specimen Collection ◽  
Lymph Node Examination
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