scholarly journals Low, rather than high, body mass index confers increased risk for post-liver transplant death and graft loss: Risk modulated by model for end-stage liver disease

2015 ◽  
Vol 21 (10) ◽  
pp. 1286-1294 ◽  
Author(s):  
Kiran M. Bambha ◽  
Jennifer L. Dodge ◽  
Jane Gralla ◽  
David Sprague ◽  
Scott W. Biggins
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Liver Transplant ◽  
Body Mass ◽  
Graft Loss ◽  
High Body Mass Index ◽  
End Stage Liver Disease ◽  
High Body ◽  
Increased Risk ◽  
End Stage

scholarly journals The Future Excess Fraction of Cancer Attributable to High Body Mass Index in Australia

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 194s-194s ◽  
Author(s):  
R. Carey ◽  
R. Norman ◽  
D. Whiteman ◽  
A. Reid ◽  
R. Neale ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Adult Population ◽  
Significant Proportion ◽  
High Body Mass Index ◽  
Overweight And Obesity ◽  
High Body ◽  
Increased Risk ◽  
The Future ◽  
Future Burden

Background: High body mass index (BMI > 25 kg/m2) has been found to be associated with an increased risk of many cancers, including cancers of the colon and rectum, liver, and pancreas. Aim: This study aimed to estimate the future burden of cancer resulting from current levels of overweight and obesity in Australia. Methods: The future excess fraction method was used to estimate the future burden of cancer among the proportion of the Australian adult population who were overweight or obese in 2016. Calculations were conducted for 13 cancer types, including cancers of the colon, rectum, kidney, and liver. Results: The cohort of 18.7 million adult Australians in 2016 will develop ∼7.6 million cancers over their lifetime. Of these, ∼402,500 cancers (5.3%) will be attributable to current levels of overweight and obese. The majority of these will be postmenopausal breast cancers (n = 72,300), kidney cancers (n = 59,200), and colon cancers (n = 55,100). More than a quarter of future endometrial cancers (30.3%) and esophageal adenocarcinomas (35.8%) will be attributable to high body mass index. Conclusion: A significant proportion of future cancers will result from current levels of high body mass index. Our estimates are not directly comparable to past estimates of the burden from overweight and obesity because they describe different quantities - future cancers in currently exposed vs current cancers due to past exposures. The results of this study provide us with relevant up-to-date information about how many cancers in Australia could be prevented.

The Effectiveness of a Balance Training Intervention in Reducing the Incidence of Noncontact Ankle Sprains in High School Football Players

2007 ◽  
Vol 35 (8) ◽  
pp. 1289-1294 ◽  
Author(s):  
Malachy P. McHugh ◽  
Timothy F. Tyler ◽  
Michael R. Mirabella ◽  
Michael J. Mullaney ◽  
Stephen J. Nicholas
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Ankle Sprain ◽  
Balance Training ◽  
High Body Mass Index ◽  
Football Players ◽  
Injury Incidence ◽  
Ankle Sprains ◽  
High Body ◽  
Increased Risk

Background A high body mass index and previous ankle sprains have been shown to increase the risk of sustaining noncontact inversion ankle sprains in high school football players. Hypothesis Stability pad balance training reduces the incidence of noncontact inversion ankle sprains in football players with increased risk. Study Design Cohort study; Level of evidence, 2. Methods Height, body mass, history of previous ankle sprains, and current ankle brace/tape use were documented at the beginning of preseason training in 2 high school varsity football teams for 3 consecutive years (175 player-seasons). Players were categorized as minimal risk, low risk, moderate risk, and high risk based on the history of previous ankle sprain and body mass index. Players in the low-, moderate-, and high-risk groups (ie, any player with a high body mass index and/or a previous ankle sprain) were placed on a balance training intervention on a foam stability pad. Players balanced for 5 minutes on each leg, 5 days per week, for 4 weeks in preseason and twice per week during the season. Postintervention injury incidence was compared with preintervention incidence (107 players-seasons) for players with increased risk. Results Injury incidence for players with increased risk was 2.2 injuries per 1000 exposures (95% confidence interval, 1.1-3.8) before the intervention and 0.5 (95% confidence interval, 0.2-1.3) after the intervention (P < .01). This represents a 77% reduction in injury incidence (95% confidence interval, 31%-92%). Conclusion The increased risk of a noncontact inversion ankle sprain associated with a high body mass index and a previous ankle sprain was eliminated by the balance training intervention.

Impact of a High Body Mass Index on Lower Extremity Injury in Marathon/Half-Marathon Participants

2012 ◽  
Vol 9 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Tyler F. Vadeboncoeur ◽  
Scott M. Silvers ◽  
Walter C. Taylor ◽  
Shane A. Shapiro ◽  
Jennifer A. Roth ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lower Extremity ◽  
Body Mass ◽  
High Body Mass Index ◽  
Primary Outcome Measure ◽  
Lower Extremity Injury ◽  
Extremity Injury ◽  
Lower Extremity Injuries ◽  
High Body ◽  
Increased Risk

Background:To evaluate whether a high body mass index (BMI) predisposes marathon/half-marathon participants to lower extremity injuries.Methods:Consenting adult participants at the 2008 National Marathon to Fight Breast Cancer were enrolled in this observational study. The primary outcome measure was prevalence of self-reported lower extremity injury, during both training and race participation, with respect to BMI.Results:There were 194 subjects with complete data: 139 females (72%) and 55 males. Forty-six percent of females and 51% of males ran the full marathon (P = .63). Median BMI was 23.7 kg/m2 for females and 26.2 kg/m2 for males (P = .001). Eleven (24%) females in BMI tertile 1 (T1) suffered a training injury, while 9 (18%) from T2 and 4 (9%) from T3 suffered injuries (P = .072; OR 0.89; 95% CI 0.78 to 1.01). Twenty-six (19%) females suffered an injury during the race. Females in T1 were more likely to suffer a race-related injury (P = .038; OR 0.87; 95% CI 0.77 to 0.99). Females were 13% less likely to suffer a race-related injury with each 1-unit increase in BMI. Rates of injury did not differ by BMI tertile in males.Conclusions:A high BMI did not impart an increased risk of lower extremity injury during training or race participation.

Su1879 - High Body Mass Index is Associated with Increased Risk of Treatment Failure and Surgery in Biologic-Treated Patients with Ulcerative Colitis

2018 ◽  
Vol 154 (6) ◽  
pp. S-617
Author(s):  
Soumya Kurnool ◽  
Nghia H. Nguyen ◽  
James Proudfoot ◽  
Parambir Dulai ◽  
Brigid S. Boland ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Body Mass Index ◽  
Treatment Failure ◽  
Body Mass ◽  
High Body Mass Index ◽  
High Body ◽  
Increased Risk ◽  
Risk Of Treatment

scholarly journals Pre-Liver Transplant ROTEM™ Clot Lysis Index Is Associated with 30-Day Mortality, But Is Not a Measure for Fibrinolysis

2020 ◽  
Vol 9 (10) ◽  
pp. 3298
Author(s):  
Matthias Hartmann ◽  
Bogdan Craciun ◽  
Andreas Paul ◽  
Thorsten Brenner ◽  
Fuat H. Saner
Keyword(s):  
Liver Disease ◽  
Liver Transplant ◽  
Blood Product ◽  
Meld Score ◽  
Coagulation System ◽  
Clot Lysis ◽  
End Stage Liver Disease ◽  
Product Use ◽  
Increased Risk ◽  
End Stage

Complex alterations of the coagulation system in end stage liver disease lead to an increased risk of bleeding and mortality. In the present study, we investigated; 1. the association of pre-liver transplant rotational thrombelastometry (ROTEM™) variables with bleeding as well as 30-day-mortality and 2. the underlying pathophysiology. After approval from the local ethics committee, rotational thrombelastometry variables, conventional laboratory coagulation values, MELD score (model of end-stage liver disease), red blood cell loss, blood product use, coagulation factors, underlying disease, and demographic data were retrospectively analysed. Pre-transplant thrombelastometry clot lysis index (CLI) and MELD were the only variables associated with mortality, bleeding and blood product use, respectively. Mortality was 4.2%, when CLI was <85%, and increased to 25.7% when the CLI was >95%. Multivariate analysis including CLI and MELD score identified the CLI as an independent and the best predictor of 30-day-mortality. Interestingly, the inhibition of fibrinolysis did neither affect CLI nor the association of the variable with mortality. Thus, fibrinolysis can be excluded as the reason for low CLI values. In conclusion, low CLI values measured before the beginning of liver transplantation are associated with reduced bleeding and mortality, but do not indicate fibrinolysis.

scholarly journals Multidrug-Resistant Bacteria and Disease Progression in Patients with End-Stage Liver Disease and after Liver Transplantation

2019 ◽  
Vol 28 (3) ◽  
pp. 303-310 ◽  
Author(s):  
Kilian Friedrich ◽  
Jessica Krempl ◽  
Shigehiko Schamoni ◽  
Theresa Hippchen ◽  
Jan Pfeiffenberger ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Transplant ◽  
Multidrug Resistant ◽  
Waiting List ◽  
Resistant Bacteria ◽  
Actuarial Survival ◽  
End Stage Liver Disease ◽  
Increased Risk ◽  
End Stage ◽  
The Impact

Background: Multidrug-resistant (MDR) pathogens represent an emerging challenge in end-stage liver disease and in liver transplant recipients. Methods: We evaluated the impact of MDR bacteria upon clinical outcomes in patients with end-stage liver disease (n = 777) at the time of enrollment on the liver transplant (LTx) waiting list, after first LTx (n = 645), and after second LTx (n = 128). Results: Colonization/infection with MDR bacteria was present in 72/777 patients on the waiting list, in 98/645 patients at first LTx, and in 46/128 patients at second LTx. While on the LTx waiting list, the time until first hydropic decompensation (p = 0.021), hepatic encephalopathy (p < 0.001) and hepatorenal syndrome (p < 0.001) was reduced in the presence of MDR bacteria, which remained an independent risk factor of poor survival in multivariate analysis (p < 0.001). Following first and second liver transplant, MDR bacteria were associated with an increased risk of infection-related deaths (first LTx: p < 0.001; second LTx: p = 0.037) and reduced actuarial survival (first LTx: p < 0.001; second LTx: p = 0.046). Conclusions: We showed that MDR pathogens are associated with poor outcomes before, after first and after recurrent LTx.

scholarly journals High body mass index is associated with increased risk of implant dislocation following primary total hip replacement: 2,106 patients followed for up to 8 years

2008 ◽  
Vol 79 (1) ◽  
pp. 141-147 ◽  
Author(s):  
Omid Sadr Azodi ◽  
Johanna Adami ◽  
David Lindström ◽  
Karl O Eriksson ◽  
Andreas Wladis ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
High Body Mass Index ◽  
Total Hip ◽  
High Body ◽  
Increased Risk ◽  
Implant Dislocation
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