scholarly journals Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer

2020 ◽  
Vol 59 (8) ◽  
pp. 955-966
Author(s):  
Eswar Shankar ◽  
Mitali Pandey ◽  
Shiv Verma ◽  
Ata Abbas ◽  
Mario Candamo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Histone Deacetylases ◽  
Class I ◽  
Maspin Expression

scholarly journals Androgen Receptor Signalling in Prostate Cancer: The Functional Consequences of Acetylation

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Derek N. Lavery ◽  
Charlotte L. Bevan
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Progression ◽  
Histone Deacetylases ◽  
Transcriptional Response ◽  
Fine Tuning ◽  
Receptor Signalling ◽  
Prostate Carcinogenesis ◽  
Functional Consequences

The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors. In the early stages of prostate carcinogenesis, tumour growth is dependent on androgens, and AR directly mediates these effects by modulating gene expression. During transcriptional regulation, the AR recruits numerous cofactors with acetylation-modifying enzymatic activity, the best studied include p300/CBP and the p160/SRC family of coactivators. It is known that recruitment of histone acetyltransferases (HATs) and histone deacetylases (HDACs) is key in fine-tuning responses to androgens and is thus likely to play a role in prostate cancer progression. Further, these proteins can also modify the AR itself. The functional consequences of AR acetylation, the role of modifying enzymes in relation to AR transcriptional response, and prostate cancer will be discussed.

scholarly journals The role of histone deacetylases in prostate cancer

Epigenetics ◽  
2008 ◽  
Vol 3 (6) ◽  
pp. 300-309 ◽  
Author(s):  
Ata Abbas ◽  
Sanjay Gupta
Keyword(s):  
Prostate Cancer ◽  
Histone Deacetylases

scholarly journals Regulating the Regulators: The Post-Translational Code of Class I HDAC1 and HDAC2

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Chiara V. Segré ◽  
Susanna Chiocca
Keyword(s):  
Signaling Pathways ◽  
Histone Deacetylases ◽  
Cell Types ◽  
Class I ◽  
Homologous Proteins ◽  
Post Translational Modifications ◽  
Different Cell Types ◽  
Differential Context

Class I histone deacetylases (HDACs) are cellular enzymes expressed in many tissues and play crucial roles in differentiation, proliferation, and cancer. HDAC1 and HDAC2 in particular are highly homologous proteins that show redundant or specific roles in different cell types or in response to different stimuli and signaling pathways. The molecular details of this dual regulation are largely unknown. HDAC1 and HDAC2 are not only protein modifiers, but are in turn regulated by post-translational modifications (PTMs): phosphorylation, acetylation, ubiquitination, SUMOylation, nitrosylation, and carbonylation. Some of these PTMs occur and crosstalk specifically on HDAC1 or HDAC2, creating a rational “code” for a differential, context-related regulation. The global comprehension of this PTM code is central for dissecting the role of single HDAC1 and HDAC2 in physiology and pathology.

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

2008 ◽  
Vol 14 (6) ◽  
pp. 1669-1677 ◽  
Author(s):  
W. Weichert ◽  
A. Roske ◽  
S. Niesporek ◽  
A. Noske ◽  
A.-C. Buckendahl ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Histone Deacetylase ◽  
Histone Deacetylases ◽  
Specific Role ◽  
Class I ◽  
Prognostic Impact ◽  
Human Colorectal Cancer

scholarly journals Class I Histone Deacetylase Thd1p Promotes Global Chromatin Condensation in Tetrahymena thermophila

2007 ◽  
Vol 6 (10) ◽  
pp. 1913-1924 ◽  
Author(s):  
Kathryn Parker ◽  
Julia Maxson ◽  
Alissa Mooney ◽  
Emily A. Wiley
Keyword(s):  
Histone Deacetylases ◽  
Large Scale ◽  
Tetrahymena Thermophila ◽  
Chromatin Condensation ◽  
Histone H1 ◽  
Class I ◽  
Specific Class ◽  
Chromatin Dynamics ◽  
Core Histones

ABSTRACT Class I histone deacetylases (HDACs) regulate DNA-templated processes such as transcription. They act both at specific loci and more generally across global chromatin, contributing to acetylation patterns that may underlie large-scale chromatin dynamics. Although hypoacetylation is correlated with highly condensed chromatin, little is known about the contribution of individual HDACs to chromatin condensation mechanisms. Using the ciliated protozoan Tetrahymena thermophila, we investigated the role of a specific class I HDAC, Τhd1p, in the reversible condensation of global chromatin. In this system, the normal physiological response to cell starvation includes the widespread condensation of the macronuclear chromatin and general repression of gene transcription. We show that the chromatin in Thd1p-deficient cells failed to condense during starvation. The condensation failure correlated with aberrant hyperphosphorylation of histone H1 and the overexpression of CDC2, encoding the major histone H1 kinase. Changes in the rate of acetate turnover on core histones and in the distribution of acetylated lysines 9 and 23/27 on histone H3 isoforms that were found to correlate with normal chromatin condensation were absent from Thd1p mutant cells. These results point to a role for a class I HDAC in the formation of reversible higher-order chromatin structures and global genome compaction through mechanisms involving the regulation of H1 phosphorylation and core histone acetylation/deacetylation kinetics.

Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA

2003 ◽  
Vol 310 (2) ◽  
pp. 529-536 ◽  
Author(s):  
Keith B Glaser ◽  
Junling Li ◽  
Michael J Staver ◽  
Ru-Qi Wei ◽  
Daniel H Albert ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Class Ii ◽  
Carcinoma Cells ◽  
Class I

410: Cleavage of E-Cadherin and the Role of an 80KDa Fragment in the Metastatic Progression of Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 108-108
Author(s):  
Rainer Kuefer ◽  
Kathleen Day ◽  
Jonathan Rios-Doria ◽  
Matthias Hofer ◽  
Arul Chinnaiyan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metastatic Progression ◽  
E Cadherin

The role of WNT5A in tumor and tumor surrounding tissue in primary and metastatic prostate cancer

2020 ◽  
Author(s):  
W Kisel ◽  
S Conrad ◽  
S Füssel ◽  
U Sommer ◽  
GB Baretton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
Surrounding Tissue
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