Local field potentials and oscillatory activity of the internal globus pallidus in myoclonus–dystonia

2007 ◽  
Vol 22 (3) ◽  
pp. 369-376 ◽  
Author(s):  
Elisabeth M.J. Foncke ◽  
Lo J. Bour ◽  
Johannes D. Speelman ◽  
Johannes H.T.M. Koelman ◽  
Marina A.J. Tijssen
Keyword(s):  
Globus Pallidus ◽  
Local Field ◽  
Local Field Potentials ◽  
Oscillatory Activity ◽  
Field Potentials ◽  
Internal Globus Pallidus ◽  
Myoclonus Dystonia

scholarly journals Characteristics of Globus Pallidus Internus Local Field Potentials in Hyperkinetic Disease

2018 ◽  
Vol 9 ◽  
Author(s):  
Guanyu Zhu ◽  
Xinyi Geng ◽  
Zheng Tan ◽  
Yingchuan Chen ◽  
Ruili Zhang ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Local Field ◽  
Local Field Potentials ◽  
Globus Pallidus Internus ◽  
Field Potentials

FC26.1 Representation of the dystonic symptoms in the local field potentials of the globus pallidus

2006 ◽  
Vol 117 ◽  
pp. 1-2
Author(s):  
X. Liu ◽  
W. Shouyan ◽  
J. Yianni ◽  
P. Bain ◽  
J. Stein ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Local Field ◽  
Local Field Potentials ◽  
Field Potentials

scholarly journals Oscillations of Local Field Potentials in the Rat Dorsal Striatum During Spontaneous and Instructed Behaviors

2007 ◽  
Vol 97 (5) ◽  
pp. 3800-3805 ◽  
Author(s):  
William E. DeCoteau ◽  
Catherine Thorn ◽  
Daniel J. Gibson ◽  
Richard Courtemanche ◽  
Partha Mitra ◽  
...  
Keyword(s):  
Local Field ◽  
Local Field Potentials ◽  
Dorsal Striatum ◽  
Oscillatory Activity ◽  
Field Potentials ◽  
Theta Band ◽  
Maze Task ◽  
Action Sequence ◽  
Frequency Coding ◽  
And Performance

Oscillatory activity is a candidate mechanism for providing frequency coding for the generation, storage and replay of sequential representations of events and episodes. We recorded local field potentials (LFPs) and spike activity in the striatum, a basal ganglia structure implicated in behavioral action-sequence learning and performance, as rats engaged in spontaneous and instructed behaviors in a T-maze task. We found that during voluntary behaviors, striatal LFPs exhibit prominent theta-band oscillations together with rhythms at higher and lower frequencies. Analysis of the theta-band activity demonstrated that these oscillations are strongly modulated during task performance and increase as the animals choose and execute their turning responses in the cue-instructed T-maze task. These theta rhythms are locally generated and are coherent across large parts of the striatum. We suggest that modulation of oscillatory activity in the striatum may be a key feature of neural processing related to the control of voluntary behavior.

Oscillatory activity in sensorimotor cortex of awake monkeys: synchronization of local field potentials and relation to behavior

1996 ◽  
Vol 76 (6) ◽  
pp. 3949-3967 ◽  
Author(s):  
V. N. Murthy ◽  
E. E. Fetz
Keyword(s):  
Phase Shift ◽  
Local Field ◽  
Sensorimotor Cortex ◽  
Local Field Potentials ◽  
Phase Shifts ◽  
Oscillatory Activity ◽  
Field Potentials ◽  
Average Strength ◽  
Probability Of Occurrence ◽  
40 Hz

1. Oscillations of 20-40 Hz were observed in local field potentials (LFPs) and unit activity in sensorimotor cortices of three awake monkeys while the monkeys performed trained wrist movements and untrained exploratory arm movements. The mean frequency of LFP oscillations was 25.9 +/- 1.4 (SD) Hz and the number of cycles of oscillations per episode was variable, with a mean of 4.2 +/- 0.5 (mean +/- SE). 2. Oscillatory episodes occurred most often when the monkeys retrieved raisins from a Kluver board (0.59 +/- 0.23 episodes per s, mean +/- SD) or from unseen locations with the use of somatosensory feedback (0.62 +/- 0.12 episodes per s); they occurred less often when the monkeys performed repetitive wrist flexion and extension movements (0.22 +/- 0.04 episodes per s) or sat quietly at rest (0.23 +/- 0.17 episodes per s). 3. The amplitude of LFP oscillations increased with depth in cortex, reaching a maximum between 1 and 2 mm. LFP oscillations at the surface of the cortex were 180 degrees out of phase with oscillations in the deep cortical layers. The phase shift (with respect to the deep layers) decreased with depth in the cortex and disappeared at depths of > 1 mm. 4. LFPs were recorded simultaneously at multiple sites in the sensorimotor cortex when monkeys retrieved raisins from a Kluver board or from unseen locations. Cross-correlation of LFPs recorded at different sites indicated that oscillations in the 20- to 40-Hz range could become synchronized at sites separated by up to > or = 14 mm in the precentral cortex. 5. The probability of occurrence of significant correlations between LFP oscillations at paired sites and the average correlation amplitude decreased with increasing horizontal separation of sites in precentral cortex. The phase shift between LFP oscillations recorded at paired sites did not change significantly with increasing horizontal separation. 6. For paired sites in precentral cortex, the average strength of correlations and the proportion of oscillations that were significantly correlated were greater during exploratory behaviors such as retrieving raisins from slots of the Kluver board than during periods of rest or overtrained wrist movements. 7. Oscillations could become synchronized with small phase shifts (0.5 +/- 1.6 ms) between pre- and postcentral cortical sites. Average strength and probability of occurrence of significant correlations between pre- and postcentral LFPs increased during exploratory behaviors. 8. Oscillations occurred simultaneously in the left and right motor cortex and could become synchronized with negligible phase shifts when the monkey performed bimanual manipulations. However, synchronization occurred as often and as strongly for unimanual as for bimanual manipulations. 9. These results indicate that episodes of 20- to 40-Hz oscillations occur often and become synchronized over a large cortical area during exploratory forelimb movements. However, they have no reliable relation to particular components of the movement and therefore seem unlikely to be involved directly in movement execution; instead, they may represent a neural correlate of attention during demanding sensorimotor behaviors.

Characteristics of globus pallidus internus local field potentials in generalized dystonia patients with TWNK mutation

2020 ◽  
Vol 131 (7) ◽  
pp. 1453-1461 ◽  
Author(s):  
Guan-Yu Zhu ◽  
Rui-Li Zhang ◽  
Ying-Chuan Chen ◽  
Yu-Ye Liu ◽  
De-Feng Liu ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Local Field ◽  
Local Field Potentials ◽  
Globus Pallidus Internus ◽  
Field Potentials ◽  
Generalized Dystonia

scholarly journals Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy

2021 ◽  
Vol 11 (7) ◽  
pp. 882
Author(s):  
Yeon Hee Yu ◽  
Seong-Wook Kim ◽  
Dae-Kyoon Park ◽  
Ho-Yeon Song ◽  
Duk-Soo Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Local Field ◽  
Smooth Muscle Actin ◽  
Local Field Potentials ◽  
Renal Tissue ◽  
Field Potentials ◽  
Wild Type ◽  
Sprague Dawley ◽  
Rat Models

Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia.

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