scholarly journals Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3T

2017 ◽  
Vol 79 (2) ◽  
pp. 806-814 ◽  
Author(s):  
Samantha By ◽  
Robert L. Barry ◽  
Alex K. Smith ◽  
Bailey D. Lyttle ◽  
Bailey A. Box ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Proton Transfer ◽  
Cervical Spinal Cord ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Multiple Sclerosis Patients

Semi-automatic segmentation and modeling of the cervical spinal cord for volume quantification in multiple sclerosis patients from magnetic resonance images

2008 ◽  
Author(s):  
Pavlina Sonkova ◽  
Iordanis E. Evangelou ◽  
Antonio Gallo ◽  
Fredric K. Cantor ◽  
Joan Ohayon ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Cervical Spinal Cord ◽  
Automatic Segmentation ◽  
Magnetic Resonance Images ◽  
Multiple Sclerosis Patients

scholarly journals Application and evaluation of NODDI in the cervical spinal cord of multiple sclerosis patients

2017 ◽  
Vol 15 ◽  
pp. 333-342 ◽  
Author(s):  
Samantha By ◽  
Junzhong Xu ◽  
Bailey A. Box ◽  
Francesca R. Bagnato ◽  
Seth A. Smith
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Multiple Sclerosis Patients

scholarly journals Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adam V. Dvorak ◽  
Emil Ljungberg ◽  
Irene M. Vavasour ◽  
Lisa Eunyoung Lee ◽  
Shawna Abel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Steady State ◽  
Cervical Spinal Cord ◽  
Traditional Approach ◽  
Quantitative Mri ◽  
Z Score ◽  
Water Fraction ◽  
Multiple Sclerosis Patients ◽  
Myelin Imaging

AbstractThe traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state acquisition to generate an equivalent metric (fM). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT analysis procedure, fM has often been used as a surrogate for MWF. We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology. A significant bias was found in all regions (p < 10–5), albeit reversed for spinal cord (fM-MWF =  − 3.4%) compared to brain (+ 6.2%). MWF and fM followed an approximately linear relationship for regions with MWF <  ~ 10%. For MWF >  ~ 10%, the relationship broke down and fM no longer increased in tandem with MWF. For multiple sclerosis patients, MWF and fM Z score maps showed overlapping areas of low Z score and similar trends between patients and brain regions, although those of fM generally had greater spatial extent and magnitude of severity. These results will guide future choice of myelin-sensitive quantitative MRI and improve interpretation of studies using either myelin imaging approach.

scholarly journals Amide Proton Transfer Weighted Imaging Shows Differences in Multiple Sclerosis Lesions and White Matter Hyperintensities of Presumed Vascular Origin

2019 ◽  
Vol 10 ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Anton S. Becker ◽  
Árpád Schwenk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Proton Transfer ◽  
White Matter Hyperintensities ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Vascular Origin

Comparison of BLADE and conventional T2-TSE sequences for the sagittal visualization of the cervical spinal cord in multiple sclerosis patients — A case report

2013 ◽  
Vol 31 (10) ◽  
pp. 1766-1770 ◽  
Author(s):  
Eleftherios Lavdas ◽  
Panayiotis Mavroidis ◽  
Theofilos Topaltzikis ◽  
Vasileios Slatinopoulos ◽  
Violeta Roka ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Case Report ◽  
Cervical Spinal Cord ◽  
Multiple Sclerosis Patients

scholarly journals Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Carolin Reischauer ◽  
Luuk van Smoorenburg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Brain Tumors ◽  
Proton Transfer ◽  
Multilayer Perceptron ◽  
Random Forest Classifier ◽  
Amide Proton ◽  
Low Grade ◽  
Who Grade ◽  
Amide Proton Transfer

AbstractWe sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

scholarly journals Prediction of H3K27M-mutant brainstem glioma by amide proton transfer–weighted imaging and its derived radiomics

2021 ◽  
Author(s):  
Zhizheng Zhuo ◽  
Liying Qu ◽  
Peng Zhang ◽  
Yunyun Duan ◽  
Dan Cheng ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Brainstem Glioma ◽  
Amide Proton ◽  
Amide Proton Transfer

Amide proton transfer imaging for differentiation of tuberculomas from high-grade gliomas: Preliminary experience

2021 ◽  
pp. 197140092110027
Author(s):  
Karthik Kulanthaivelu ◽  
Shumyla Jabeen ◽  
Jitender Saini ◽  
Sanita Raju ◽  
Atchayaram Nalini ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Spin Echo ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
High Grade ◽  
Saturation Pulse ◽  
Amide Proton Transfer ◽  
High Grade Gliomas ◽  
Amide Protons

Purpose Tuberculomas can occasionally masquerade as high-grade gliomas (HGG). Evidence from magnetisation transfer (MT) imaging suggests that there is lower protein content in the tuberculoma microenvironment. Building on the principles of chemical exchange saturation transfer and MT, amide proton transfer (APT) imaging generates tissue contrast as a function of the mobile amide protons in tissue’s native peptides and intracellular proteins. This study aimed to further the understanding of tuberculomas using APT and to compare it with HGG. Method Twenty-two patients ( n = 8 tuberculoma; n = 14 HGG) were included in the study. APT was a 3D turbo spin-echo Dixon sequence with inbuilt B0 correction. A two-second, 2 μT saturation pulse alternating over transmit channels was applied at ±3.5 ppm around water resonance. The APT-weighted image (APTw) was computed as the MT ratio asymmetry (MTRasym) at 3.5 ppm. Mean MTRasym values in regions of interest (areas = 9 mm2; positioned in component with homogeneous enhancement/least apparent diffusion coefficient) were used for the analysis. Results MTRasym values of tuberculomas ( n = 14; 8 cases) ranged from 1.34% to 3.11% ( M = 2.32 ± 0.50). HGG ( n = 17;14 cases) showed MTRasym ranging from 2.40% to 5.70% ( M = 4.32 ± 0.84). The inter-group difference in MTRasym was statistically significant ( p < 0.001). APTw images in tuberculomas were notable for high MTRasym values in the perilesional oedematous-appearing parenchyma (compared to contralateral white matter; p < 0.001). Conclusion Tuberculomas demonstrate lower MTRasym ratios compared to HGG, reflective of a relative paucity of mobile amide protons in the ambient microenvironment. Elevated MTRasym values in perilesional parenchyma in tuberculomas are a unique observation that may be a clue to the inflammatory milieu.

Sign in / Sign up

Export Citation Format

Share Document