Muscle shear modulus measured with ultrasound shear-wave elastography across a wide range of contraction intensity

AbstractThe objectives of this study were to examine the intra and inter-operator reliability of shear wave elastography (SWE) device in quantifying the shear modulus of thoracolumbar fascia (TLF) and the device’s abilities to examine the shear modulus of the TLF during upper body forward. Twenty healthy male subjects participated in this study (mean age: 18.4 ± 0.7 years). Two independent operators performed the shear modulus of TLF during upper body forward using SWE, and interclass correlation coefficient (ICC) and minimum detectable change (MDC) were calculated. The shear modulus of the TLF was quantified by operator A using SWE at upper body forward 60°. The intra-operator (ICC = 0.860–0.938) and inter-operator (ICC = 0.904–0.944) reliabilities for measuring the shear modulus of the TLF with the upper body forward 0° were rated as both excellent, and the MDC was 4.71 kPa. The TLF shear modulus of upper body forward 60°was increased 45.5% (L3) and 55.0% (L4) than that of upper body forward 0°. The results indicate that the SWE is a dependable tool to quantify the shear modulus of TLF and monitor its dynamic changes. Therefore, this device can be used for biomechanical study and intervention experiments of TLF.

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Abstract 139: Future Clinical Tools: Carotid Plaque Characterization via Shear Wave Elastography - A Phantom Study

Stroke ◽

10.1161/str.46.suppl_1.139 ◽

2015 ◽

Vol 46 (suppl_1) ◽

Author(s):

Erik Widman ◽

Elira Maksuti ◽

Matthew Urban ◽

Kenneth Caidahl ◽

Matilda Larsson

Keyword(s):

Shear Modulus ◽

Mechanical Testing ◽

Shear Wave ◽

High Speed ◽

Acoustic Radiation ◽

Shear Wave Elastography ◽

Radiation Force ◽

Acoustic Radiation Force ◽

Good Agreement

Introduction: Shear Wave Elastography (SWE) is a recently developed noninvasive method for elastography assessment using ultrasound. The technique consists of sending an acoustic radiation force into the tissue that in turn generates an orthogonal low frequency propagating shear wave. The shear wave propagation speed, which is calculated from B-mode images, is correlated to the tissues mechanical properties. Currently, SWE is primarily used in breast and liver to detect tumors easily missed with normal B-mode ultrasound. SWE could potentially aid in the characterization of plaques in the carotid artery, which is critical for the prevention of ischemic stroke. Methods: Six polyvinyl alcohol (PVA) phantoms were created with soft and hard plaque mimicking inclusions. The plaques were excited with acoustic radiation force and the shear wave was measured using high speed B-mode imaging. The data was post-processed with a custom in-house algorithm fitting a model of a Lamb wave propagating through a plate to the shear wave dispersion curve, which allowed the shear modulus to be estimated. The results were validated by measuring the phantom plaque shear modulus with mechanical testing. Results: SWE measured a mean shear modulus of 6 ± 1 kPa and 106 ± 17 kPa versus 3 kPa and 95 kPa measured by mechanical testing in the soft and hard plaques respectively. The results show good agreement between the shear modulus measured with SWE and mechanical testing. In this study simplified homogenous phantom plaque models were examined in a static experimental setup with results validated by mechanical testing. Algorithm improvements for measurements in a dynamic environment are being developed for a future in vivo pilot study. Conclusion: The results show good agreement between the shear modulus measured with SWE and mechanical testing and indicate the possibility for an in vivo application.

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Shear modulus of multifidus and longissimus muscles measured using shear wave elastography correlates with muscle activity, but depends on image quality

Journal of Electromyography and Kinesiology ◽

10.1016/j.jelekin.2020.102505 ◽

2021 ◽

Vol 56 ◽

pp. 102505

Author(s):

Louise Tier ◽

Sauro E. Salomoni ◽

François Hug ◽

Manuela Besomi ◽

Paul W. Hodges

Keyword(s):

Image Quality ◽

Shear Modulus ◽

Shear Wave ◽

Muscle Activity ◽

Shear Wave Elastography

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Quantification of Shear Modulus in In Vitro Porcine Myocardium Using Real-Time Shear Wave Elastography

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2013.02.148 ◽

2013 ◽

Vol 39 (5) ◽

pp. S28

Author(s):

Y.B. Deng ◽

Q.Y. Tang ◽

J. Sun ◽

W. Zhou

Keyword(s):

Shear Modulus ◽

Real Time ◽

Shear Wave ◽

Shear Wave Elastography

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Validity of Measurement of Shear Modulus by Ultrasound Shear Wave Elastography in Human Pennate Muscle

PLoS ONE ◽

10.1371/journal.pone.0124311 ◽

2015 ◽

Vol 10 (4) ◽

pp. e0124311 ◽

Cited By ~ 56

Author(s):

Naokazu Miyamoto ◽

Kosuke Hirata ◽

Hiroaki Kanehisa ◽

Yasuhide Yoshitake

Keyword(s):

Shear Modulus ◽

Shear Wave ◽

Shear Wave Elastography

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Shear Wave Elasticity by Tracing Total Nodule Showed High Reproducibility and Concordance with Fibrosis in Thyroid Cancer

10.21203/rs.2.11903/v3 ◽

2019 ◽

Author(s):

Myung Hi Yoo(New Corresponding Author) ◽

Hye Jeong Kim(Former Corresponding Author) ◽

In Ho Choi ◽

Suyeon Park ◽

Sang Jin Kim ◽

...

Keyword(s):

Thyroid Cancer ◽

Clinical Practice ◽

Shear Wave ◽

Thyroid Nodules ◽

Intraclass Correlation ◽

Region Of Interest ◽

Shear Wave Elastography ◽

Circular Area ◽

High Reproducibility ◽

Wide Range

Abstract Background Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The cause of discrepancy remains unclear. Fibrosis of the tumors is known to increase the EI in SWE, and matching of SWE and surgical histopathology has not been fully illustrated in thyroid cancer. We aimed to evaluate the reproducibility of the new total nodular region of interest (ROI) method excluding the subjective features of focal circular ROI placement and to determine the lesion that causes the elevation of EI on SWE and on histopathology. Methods A total of 29 thyroid cancers from 28 patients were included. We evaluated the reproducibility of EI in the new total nodular ROI using Q-Box Trace program and compared the EI in focal nodular ROI using a 3-mm circular area. We analyzed the correlation between fibrosis and EI. Result The coefficient of variation (CV) of the intrarater assay was significantly lower in total nodular ROI than in focal nodular ROI within the image in rater 1 (1.7% vs. 13.4%, p<0.001) and in rater 2 (1.4% vs. 16.9%, p<0.001) and in different images in rater 1 (7.6% vs. 12.3%, p=0.040) and in rater 2 (7.5% vs. 19.8%, p=0.004). Moreover, CV of the interrater assay showed similar results (14.9% vs. 19%, p=0.030). Interrater intraclass correlation coefficient showed better agreement in total nodular ROI than in focal nodular ROI (0.863 vs. 0.783). The degree of fibrosis on histopathology showed significant correlations with EI (E Mean , p<0.001; E Max , p=0.027), and the location of fibrosis was concordant with the high EI area on SWE. Conclusion Our study revealed that the new total nodular ROI method showed higher reproducibility and better agreement in intra- and interrater assay than the focal nodular ROI method, suggesting a valuable and standardized method in clinical practice. Moreover, our results showed that fibrosis in the histopathology increased EI on SWE and might lead to the discrepancy of the cut-off values in detecting thyroid cancer.

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In vivo assessment of the passive stretching response of the bi-compartmental human semitendinosus muscle using shear wave elastography

Journal of Applied Physiology ◽

10.1152/japplphysiol.00473.2021 ◽

2021 ◽

Author(s):

Adam Kositsky ◽

David J. Saxby ◽

Kim J. Lesch ◽

Rod S. Barrett ◽

Heikki Kröger ◽

...

Keyword(s):

Experimental Data ◽

Shear Modulus ◽

Shear Wave ◽

Knee Flexion ◽

Joint Angle ◽

Shear Wave Elastography ◽

Semitendinosus Muscle ◽

Passive Stretching ◽

Musculoskeletal Models

The semitendinosus muscle contains distinct proximal and distal compartments arranged anatomically in-series but separated by a tendinous inscription, with each compartment innervated by separate nerve branches. Although extensively investigated in other mammals, compartment-specific mechanical properties within the human semitendinosus have scarcely been assessed in vivo. Experimental data obtained during muscle-tendon unit stretching (e.g., slack angle) can also be used to validate and/or improve musculoskeletal model estimates of semitendinosus muscle force. The purpose of this study was to investigate the passive stretching response of proximal and distal humans semitendinosus compartments to distal joint extension. Using two-dimensional shear wave elastography, we bilaterally obtained shear moduli of both semitendinosus compartments from 14 prone-positioned individuals at ten knee flexion angles (from 90° to 0° [full extension] at 10° intervals). Passive muscle mechanical characteristics (slack angle, slack shear modulus, and the slope of the increase in shear modulus) were determined for each semitendinosus compartment by fitting a piecewise exponential model to the shear modulus-joint angle curves. We found no differences between compartments or legs for slack angle, slack shear modulus, or the slope of the increase in shear modulus. We also found the experimentally determined slack angle occurred at ~15-80° higher knee flexion angles compared to estimates from two commonly used musculoskeletal models, depending on participant and model used. Overall, these findings demonstrate that passive shear modulus-joint angle curves do not differ between proximal and distal human semitendinosus compartments, and provide experimental data to improve semitendinosus force estimates derived from musculoskeletal models.

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