Metabolic characterization of adults with binge eating in the general population: The framingham heart study

P19 Introduction: Delayed atrioventricular conduction on the electrocardiogram (ECG), manifested by PR interval prolongation, can progress to heart block. Both heart-rate slowing drugs and environmental factors may lead to PR interval prolongation; however, the heritability of the PR interval has not been studied in the general population and genetic variants in the regulation of PR duration have not been characterized. Methods: We examined the heritability of the PR interval and we tested for evidence of linkage of the PR interval to chromosomal regions in a large population-based cohort. 12-lead ECGs were obtained routinely in adult Framingham Heart Study participants as part of the clinic examination. The PR interval was measured using digital calipers. We conducted a 10 cM genome wide scan in 328 extended families (1688 genotyped subjects, 2257 phenotyped subjects, 2028 phenotyped sibling pairs). Variance component methods were used to estimate heritability and to perform linkage analysis. Results: The PR interval (adjusted for age and RR-interval) was heritable [h 2 0.32 (95% confidence interval 0.26-0.37)]. The highest multipoint LOD score for the adjusted PR interval was found on chromosome 4 (LOD score was 2.16 at 123 cM). The next highest LOD score was 1.88 (chromosome 17 at 59 cM). Conclusion: These results suggest there are influential genetic regions contributing to variability in PR interval in the general population. Defining genetic determinants of PR duration may provide insights into the pathophysiology of heart block and may help identify persons with a high susceptibility to drug-induced heart block.

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Is mitral valve prolapse more benign in a general population? Reevaluation of echo features in the Framingham heart study

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(98)81174-1 ◽

1998 ◽

Vol 31 ◽

pp. 122

Author(s):

L.A. Freed ◽

E.J. Benjamin ◽

D. Levy ◽

M.G. Larson ◽

J.C. Evans ◽

...

Keyword(s):

Mitral Valve ◽

General Population ◽

Mitral Valve Prolapse ◽

Framingham Heart Study ◽

Heart Study ◽

Echo Features

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Is Mitral Valve Prolapse More Benign in a General Population? Reevaluation of Echo Features in the Framingham Heart Study

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84235-0 ◽

1998 ◽

Vol 31 (2) ◽

pp. 122A

Author(s):

L Freed

Keyword(s):

Mitral Valve ◽

General Population ◽

Mitral Valve Prolapse ◽

Framingham Heart Study ◽

Heart Study ◽

Echo Features

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Abstract 15421: Effect of Sex and Age-group on Pulmonary Artery to Aorta Ratio in Healthy Aging: The Framingham Heart Study

Circulation ◽

10.1161/circ.142.suppl_3.15421 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Mawa Mohmand ◽

Philimon N Gona ◽

Carol J Salton ◽

Connie W Tsao ◽

Christopher J O'Donnell ◽

...

Keyword(s):

General Population ◽

Pulmonary Artery ◽

Framingham Heart Study ◽

Healthy Aging ◽

Healthy Adults ◽

Black Blood ◽

Age Group ◽

Heart Study ◽

Pulmonary Risk ◽

Referent Group

Introduction: An increased ratio of main pulmonary artery (MPA) to ascending aorta (AAo) diameters is associated with excess morbidity and mortality in COPD and pulmonary hypertension. We sought to determine: 1) whether MPA to AAo ratio (MPA:AAo) varies with sex and age in healthy adults; 2) normal upper 90 th percentile (P90) values for MPA:AAo; 3) effect of age on MPA:AAo in the general population. Methods: 1794 adults from the Framingham Heart Study Offspring cohort (65±9 y, 47% men) underwent ECG-gated T2-weighted black blood aortic CMR at 1.5T. MPA and AAo diameters were measured at MPA bifurcation level or the adjacent slice. A referent group free of hypertension, LV focal wall motion abnormality, any history of smoking, asthma, COPD, DVT and obesity was identified and stratified by sex and age group (<55, 55-64, 65-74, ≥75 y). Data are summarized as mean±SD. P90 values were determined from referent participants. We tested for sex differences by 2-sample t test and for within-sex trend across age groups using linear regression. Results: Of the 1794 Offspring, 370 met referent group criteria, among whom men had greater MPA (23.4±2.9 vs 21.3±3.1 mm, p<0.0001) and AAo (31.1±2.9 vs 28.5±3.1 mm, p< 0.0001) diameters than women, but height-indexed AAo/HT (p=0.60) and MPA/HT (p=0.33) were not different between sexes. MPA:AAo did not differ between sexes, men=0.76±0.10, women: 0.75±0.15, p=0.97. P90 values for MPA:AAo were 0.88 (men) and 0.87 (women). MPA:AAo significantly decreased with age in both sexes (see Table) due to increasing AAo; MPA did not vary with age. In the overall population MPA:AAo also decreased with greater age, but here both AAo and MPA tended to increase with advancing age. Conclusions: Among healthy adults free of hypertension, obesity, and common pulmonary risk factors, MPA:AAo ratio does not differ between sexes. In healthy aging MPA:AAo decreases with age in both sexes, due to increased AAo diameters. These patterns are consistent in the general population.

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Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the framingham heart study

ACC Current Journal Review ◽

10.1016/s1062-1458(02)01019-x ◽

2003 ◽

Vol 12 (1) ◽

pp. 37

Author(s):

L.A. Freed ◽

E.J. Benjamin ◽

D. Levy

Keyword(s):

Mitral Valve ◽

General Population ◽

Mitral Valve Prolapse ◽

Framingham Heart Study ◽

Heart Study ◽

Benign Nature

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Does Lifestyle Impact Risk, Burden and Symptomatology of Atrial Fibrillation?

Canadian Journal of General Internal Medicine ◽

10.22374/cjgim.v13isp1.310 ◽

2018 ◽

Vol 13 (SP1) ◽

Author(s):

Ratika Parkash

Keyword(s):

Atrial Fibrillation ◽

General Population ◽

Mortality Risk ◽

Framingham Heart Study ◽

Aging Population ◽

Lifetime Risk ◽

Significant Morbidity ◽

Heart Study ◽

Impact Risk

Atrial fibrillation is the most common sustained arrhythmia, affecting 1-2% of the general population and 8% of patients over the age of 80 years. The lifetime risk for development of AF is 26% for men and 23% for women. It is associated with significant morbidity, mortality and cost, but also with an increase in mortality and a six-fold risk of stroke. The Framingham heart study showed that AF was associated with a 1.5 to1.9 fold mortality risk after adjustment for the preexisting CV conditions with which AF was related. The Heart and Stroke Foundation estimates that 350 000 Canadians are living with atrial fibrillation, and that this is increasing due to Canada’s aging population.

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