Abstract 15421: Effect of Sex and Age-group on Pulmonary Artery to Aorta Ratio in Healthy Aging: The Framingham Heart Study

Introduction: An increased ratio of main pulmonary artery (MPA) to ascending aorta (AAo) diameters is associated with excess morbidity and mortality in COPD and pulmonary hypertension. We sought to determine: 1) whether MPA to AAo ratio (MPA:AAo) varies with sex and age in healthy adults; 2) normal upper 90 th percentile (P90) values for MPA:AAo; 3) effect of age on MPA:AAo in the general population. Methods: 1794 adults from the Framingham Heart Study Offspring cohort (65±9 y, 47% men) underwent ECG-gated T2-weighted black blood aortic CMR at 1.5T. MPA and AAo diameters were measured at MPA bifurcation level or the adjacent slice. A referent group free of hypertension, LV focal wall motion abnormality, any history of smoking, asthma, COPD, DVT and obesity was identified and stratified by sex and age group (<55, 55-64, 65-74, ≥75 y). Data are summarized as mean±SD. P90 values were determined from referent participants. We tested for sex differences by 2-sample t test and for within-sex trend across age groups using linear regression. Results: Of the 1794 Offspring, 370 met referent group criteria, among whom men had greater MPA (23.4±2.9 vs 21.3±3.1 mm, p<0.0001) and AAo (31.1±2.9 vs 28.5±3.1 mm, p< 0.0001) diameters than women, but height-indexed AAo/HT (p=0.60) and MPA/HT (p=0.33) were not different between sexes. MPA:AAo did not differ between sexes, men=0.76±0.10, women: 0.75±0.15, p=0.97. P90 values for MPA:AAo were 0.88 (men) and 0.87 (women). MPA:AAo significantly decreased with age in both sexes (see Table) due to increasing AAo; MPA did not vary with age. In the overall population MPA:AAo also decreased with greater age, but here both AAo and MPA tended to increase with advancing age. Conclusions: Among healthy adults free of hypertension, obesity, and common pulmonary risk factors, MPA:AAo ratio does not differ between sexes. In healthy aging MPA:AAo decreases with age in both sexes, due to increased AAo diameters. These patterns are consistent in the general population.

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The conjoint associations of adherence to physical activity and dietary guidelines with cardiometabolic health: The Framingham Heart Study

10.21203/rs.3.rs-50754/v1 ◽

2020 ◽

Author(s):

Joowon Lee ◽

Maura E. Walker ◽

Maximillian T. Bourdillon ◽

Nicole Spartano ◽

Gail T. Rogers ◽

...

Keyword(s):

Physical Activity ◽

Framingham Heart Study ◽

Lower Risk ◽

Later Life ◽

Cox Proportional Hazards ◽

Dietary Guidelines ◽

Cardiometabolic Health ◽

The Metabolic Syndrome ◽

Heart Study ◽

Referent Group

Abstract Background The conjoint associations of adherence to the recent physical activity (PA) and dietary guidelines with the metabolic syndrome (MetS) are incompletely understood. Methods We evaluated 2,379 Framingham Heart Study Third Generation participants (mean age 47 years, 54.4% women) attending examination cycle 2. We examined the cross-sectional relations of adherence to the 2018 Physical Activity Guidelines for Americans (PAG, binary; moderate to vigorous PA [MVPA] ≥ 150 minutes/week vs. <150 minutes/week) and 2015 Dietary Guidelines for Americans (DGA, binary; 2015 DGA adherence Index [DGAI-2015] ≥ median vs. <median [score 62.1/100]) with prevalence of the MetS using generalized linear models. We also related adherence to guidelines with the incidence of MetS prospectively, using Cox proportional hazards regression with discrete time intervals. Results Adherence to the 2018 PAG (odds ratio [OR] 0.49, 95% CI 0.40–0.60) and 2015 DGA (OR 0.67, 95% CI 0.51–0.90) were individually associated with lower odds of prevalent MetS, while conjoint adherence to both guidelines was associated with the lowest odds of MetS (OR 0.35, 95% CI 0.26–0.47) compared to the referent group (non-adherence to both guidelines). Adherence to the 2018 PAG (hazards ratio [HR] 0.66, 95% CI 0.50–0.88) and 2015 DGA (HR 0.68, 95% CI 0.51–0.90) were associated with lower risk of MetS, prospectively. Additionally, we observed a 52% lower risk of MetS in individuals who adhered to both guidelines compared to the referent group. Conclusions Maintaining both regular physical activity and a healthy diet in midlife may be required for optimal cardiometabolic health in later life.

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P3-348: REDUCED STRUCTURAL BRAIN NETWORK MODULARITY IN HEALTHY AGING: RESULTS FROM THE FRAMINGHAM HEART STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.3380 ◽

2019 ◽

Vol 15 ◽

pp. P1076-P1076

Author(s):

Stephan Seiler ◽

Evan Fletcher ◽

Alexa S. Beiser ◽

Jayandra J. Himali ◽

Claudia L. Satizabal ◽

...

Keyword(s):

Framingham Heart Study ◽

Healthy Aging ◽

Brain Network ◽

Heart Study ◽

Network Modularity ◽

Structural Brain Network ◽

Structural Brain

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Abstract 3117: Subclinical Aortic Atherosclerosis by Cardiovascular Magnetic Resonance Imaging Predicts Increased Cardiovascular Morbidity and Mortality in an Initially Healthy Cohort: The Framingham Heart Study

Circulation ◽

10.1161/circ.118.suppl_18.s_1095-a ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Michael L Chuang ◽

Philimon Gona ◽

Farouc A Jaffer ◽

Carol J Salton ◽

Kraig V Kissinger ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cardiovascular Magnetic Resonance ◽

Magnetic Resonance ◽

Framingham Heart Study ◽

Plaque Burden ◽

Rank Test ◽

Black Blood ◽

Aortic Atherosclerosis ◽

Heart Study ◽

Cardiovascular Morbidity And Mortality

INTRODUCTION: We sought to determine whether subclinical aortic atherosclerosis, detected noninvasively using cardiovascular magnetic resonance (CMR), predicts major adverse cardiovascular events (MACE) in adults without history or clinical manifestation of cardiovascular disease (CVD). METHODS: 318 Framingham Heart Study (FHS) Offspring cohort members (60±9 yrs, 51% women) underwent CMR in 1998–1999. Subjects were free of clinical CVD and were recruited from equal strata of age, sex and quintile of Framingham Coronary Risk score (FCRS), with double sampling of the top quintile. CMR of the descending aorta on a 1.5-T system used an ECG-triggered black-blood T2W TSE sequence with 1.03 × 0.64 × 5-mm 3 voxels, 10-mm gap. Aortic-lumen and plaque areas were hand-traced. MACE included CV death, myocardial infarction (MI), stroke or new heart failure (HF). A Cox proportional hazards model adjusted for FCRS was used to determine hazard ratio (HR) for MACE for the (within-sexes) quartile of subjects with greatest plaque burden (Q4) vs other subjects (Q1–3). Log-rank test was used to compare survival. RESULTS: CMR aortic atherosclerosis was identified in 38% of women and 41% of men. Over median 5.2-yr follow up, 38 MACE (4 deaths, 14 MIs, 12 strokes, 8 HF) occurred among 31 subjects. Greater plaque burden (Q4) was associated with 2.75-fold greater hazard of MACE (95% CI 1.33 – 5.69, p=0.007). The Figure shows Kaplan-Meier survival, log-rank p=0.0009. CONCLUSIONS: In a free-living population without history of cardiovascular disease, CMR evidence of subclinical aortic atherosclerosis was a predictor of 5-year MACE, even after adjustment for traditional cardiovascular risk factors.

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Normal reference values for thoracic and abdominal aorta and main pulmonary artery dimensions by cardiovascular magnetic resonance: the Framingham heart study

Journal of Cardiovascular Magnetic Resonance ◽

10.1186/1532-429x-15-s1-p256 ◽

2013 ◽

Vol 15 (S1) ◽

Cited By ~ 1

Author(s):

Michael L Chuang ◽

Philimon Gona ◽

Carol J Salton ◽

Connie W Tsao ◽

Susan B Yeon ◽

...

Keyword(s):

Cardiovascular Magnetic Resonance ◽

Magnetic Resonance ◽

Pulmonary Artery ◽

Reference Values ◽

Abdominal Aorta ◽

Framingham Heart Study ◽

Main Pulmonary Artery ◽

Normal Reference ◽

Heart Study ◽

Thoracic And Abdominal

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Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: the Framingham Heart Study

American Journal of Clinical Nutrition ◽

10.3945/ajcn.2009.29106 ◽

2010 ◽

Vol 92 (5) ◽

pp. 1165-1171 ◽

Cited By ~ 84

Author(s):

Nicola M McKeown ◽

Lisa M Troy ◽

Paul F Jacques ◽

Udo Hoffmann ◽

Christopher J O’Donnell ◽

...

Keyword(s):

Framingham Heart Study ◽

Healthy Adults ◽

Heart Study ◽

Subcutaneous Adiposity

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The PR Interval is a Heritable Quantitative Trait with Evidence for Linkage to Chromosome 4 in a Genome-Wide Scan: the Framingham Heart Study

Circulation ◽

10.1161/circ.103.suppl_1.9998-19 ◽

2001 ◽

Vol 103 (suppl_1) ◽

pp. 1354-1354

Author(s):

Christopher J. O’Donnell ◽

Emelia J. Benjamin ◽

Diane Corey ◽

Christopher Newton-Cheh ◽

Daniel Levy ◽

...

Keyword(s):

General Population ◽

Framingham Heart Study ◽

Heart Block ◽

Chromosome 4 ◽

Interval Prolongation ◽

Lod Score ◽

Genome Wide ◽

Heart Study ◽

Pr Interval ◽

Genome Wide Scan

P19 Introduction: Delayed atrioventricular conduction on the electrocardiogram (ECG), manifested by PR interval prolongation, can progress to heart block. Both heart-rate slowing drugs and environmental factors may lead to PR interval prolongation; however, the heritability of the PR interval has not been studied in the general population and genetic variants in the regulation of PR duration have not been characterized. Methods: We examined the heritability of the PR interval and we tested for evidence of linkage of the PR interval to chromosomal regions in a large population-based cohort. 12-lead ECGs were obtained routinely in adult Framingham Heart Study participants as part of the clinic examination. The PR interval was measured using digital calipers. We conducted a 10 cM genome wide scan in 328 extended families (1688 genotyped subjects, 2257 phenotyped subjects, 2028 phenotyped sibling pairs). Variance component methods were used to estimate heritability and to perform linkage analysis. Results: The PR interval (adjusted for age and RR-interval) was heritable [h 2 0.32 (95% confidence interval 0.26-0.37)]. The highest multipoint LOD score for the adjusted PR interval was found on chromosome 4 (LOD score was 2.16 at 123 cM). The next highest LOD score was 1.88 (chromosome 17 at 59 cM). Conclusion: These results suggest there are influential genetic regions contributing to variability in PR interval in the general population. Defining genetic determinants of PR duration may provide insights into the pathophysiology of heart block and may help identify persons with a high susceptibility to drug-induced heart block.

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A Direct Comparison of the Relationship of Epigenetic Aging and Epigenetic Substance Consumption Markers to Mortality in the Framingham Heart Study

Genes ◽

10.3390/genes10010051 ◽

2019 ◽

Vol 10 (1) ◽

pp. 51 ◽

Cited By ~ 8

Author(s):

James Mills ◽

Steven Beach ◽

Meeshanthini Dogan ◽

Ron Simons ◽

Frederick Gibbons ◽

...

Keyword(s):

Substance Use ◽

Framingham Heart Study ◽

Healthy Aging ◽

Methylation Status ◽

Cox Proportional Hazards ◽

Independent Effect ◽

Epigenetic Aging ◽

Heart Study ◽

Relationship Of ◽

The Relationship

A number of studies have examined the relationship of indices of epigenetic aging (EA) to key health outcomes. Unfortunately, our understanding of the relationship of EA to mortality and substance use-related health variables is unclear. In order to clarify these interpretations, we analyzed the relationship of the Levine EA index (LEA), as well as established epigenetic indices of cigarette (cg05575921) and alcohol consumption (cg04987734), to all-cause mortality in the Framingham Heart Study Offspring Cohort (n = 2256) Cox proportional hazards regression. We found that cg05575921 and cg04987734 had an independent effect relative to LEA and vice versa, with the model including all the predictors having better performance than models with either LEA or cg05575921 and cg04987734 alone. After correction for multiple comparisons, 195 and 327, respectively, of the 513 markers in the LEA index, as well as the overall index itself, were significantly associated with cg05575921 and cg04987734 methylation status. We conclude that the epigenetic indices of substance use have an independent effect over and above LEA, and are slightly stronger predictors of mortality in head-to-head comparisons. We also conclude that the majority of the strength of association conveyed by the LEA is secondary to smoking and drinking behaviors, and that efforts to promote healthy aging should continue to focus on addressing substance use.

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