The Primary Results of the Treating Adult Smokers at Risk for Weight Gain with Interactive Technology (TARGIT) Study

AbstractPatients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic co-morbidities. Identification of individuals with psychotic disorders with a high risk of rapid weight gain, and the associated development of metabolic complications, is an unmet need as regards public health. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 controls (CTR), 44 first-episode psychosis (FEP) patients and 22 individuals at clinical-high-risk (CHR) for psychosis, from two study centers (Turku/Finland and London/UK). Baseline serum samples were analyzed by lipidomics, while body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols with low double bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of two triacylglycerols (TG(48:0) and TG(45:0)), was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals, and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic co-morbidities.

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33 NeoCHIRP: A Collaborative Care Model for Intestinal Rehabilitation in the NICU

Paediatrics & Child Health ◽

10.1093/pch/pxaa068.032 ◽

2020 ◽

Vol 25 (Supplement_2) ◽

pp. e13-e13

Author(s):

Keerat Dhaliwal ◽

Susan Albersheim ◽

Linda Casey

Keyword(s):

At Risk ◽

Weight Gain ◽

Intestinal Failure ◽

Patient Characteristics ◽

Final Visit ◽

Oral Stimulation ◽

Z Scores ◽

Intestinal Rehabilitation ◽

Surgical Conditions ◽

Made In

Abstract Background Many children with intestinal failure (IF) start their course in the NICU with medical or surgical conditions limiting enteral feeding. Multidisciplinary intestinal rehabilitation teams have improved outcomes in pediatric IF patients, but this is not well described in neonates. Objectives NeoCHIRP represents a unique IR Team; this study describes its roles in collaborating neonatal and IR care. Design/Methods Retrospective descriptive chart review of neonates at risk for IF in one NICU, of patients admitted between April 1, 2013 and March 31, 2019. All neonates at risk for IF were evaluated weekly by a multidisciplinary Neonatal Children’s IR program in the NICU (NeoCHIRP) that is composed of surgeons, dieticians, neonatologists, IR paediatrician, nurses and patient families, to evaluate nutritional status, and provide recommendations. Data collected included weight, patient characteristics, number of NeoCHIRP visits, type of recommendations, cholestasis interventions, successful oral tolerance, and survival. Results There were 163 patients, 105 males, 58 females with 1-27 weekly visits (mean= 9.1) and gestational age between 23-43 4/7 weeks (median= 35). There were 153 survivors discharged from the NICU and 10 deaths (3 from IF related complications.) Enteral autonomy was achieved by 139/163 patients (85.3%.) Common recommendations made were enteral feeds (96.3%), parenteral nutrition (95%) or sodium management (93.9%.) Recommendations for oral stimulation were made in 79.1%, of which 40.5% (66/163) were exclusively orally fed and 20.2% partially orally fed by discharge. Cholestasis interventions were made in 66.9% and conjugated bilirubin (CB) <15 at discharge in 93 patients (range 0-123, mean 12.9 median 2) with only 23/163 patients with CB >30 at final visit. Evaluation of patient weights showed increased z-scores in only 23/153 (15%) from birth to discharge versus increased z-scores in 51/141 (36.2%) from NeoCHIRP consult to discharge. Conclusion A Multidisciplinary Neonatal Intestinal Failure Team is a useful collaborative model to support NICU medical management, by minimizing poor weight gain, cholestasis and oral aversion. Recommendations made for all NeoCHIRP patients in enteral, parenteral and sodium management resulted in improved weight gain of patients.

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Body weight, BMI and gestational weight gain are predictors of short sleep duration amongst pregnant women at risk of gestational diabetes

Proceedings of The Nutrition Society ◽

10.1017/s0029665115004346 ◽

2016 ◽

Vol 75 (OCE1) ◽

Author(s):

N.O. Alafif ◽

A.A. Alghamdi ◽

E. Tan ◽

E. Ciantar ◽

E.M. Scott ◽

...

Keyword(s):

At Risk ◽

Body Weight ◽

Weight Gain ◽

Gestational Diabetes ◽

Pregnant Women ◽

Sleep Duration ◽

Gestational Weight Gain ◽

Short Sleep Duration ◽

Short Sleep ◽

Gestational Weight

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Changing Diet and Exercise Behaviors in Individuals at Risk for Weight Gain

Obesity Research ◽

10.1002/j.1550-8528.1995.tb00474.x ◽

1995 ◽

Vol 3 (S2) ◽

pp. 277s-282s ◽

Cited By ~ 14

Author(s):

Rena R. Wing

Keyword(s):

At Risk ◽

Weight Gain ◽

Exercise Behaviors ◽

Diet And Exercise

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Cardio-Metabolic Benefits of Walnuts in Type 2 Diabetes Mellitus: A Literature Review

European Medical Journal ◽

10.33590/emj/21-00070 ◽

2021 ◽

pp. 111-124

Author(s):

Valentine Y Njike ◽

Genevieve Cecile Kela ◽

Nisar Khan ◽

Rockiy Ayettey ◽

Maxime Tindong ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

At Risk ◽

Type 2 Diabetes Mellitus ◽

Weight Gain ◽

Glycaemic Control ◽

Metabolic Risk Factors ◽

Metabolic Risk

Diabetes and its complications are main causes of morbidity and mortality among adults in the USA. An increase in the number of individuals with diabetes is primarily attributed to changes in dietary patterns including increased consumption of obesogenic foods and beverages. Many individuals who are overweight and obese show signs of insulin resistance and are at increased risk of Type 2 diabetes mellitus (T2DM) and cardiovascular disease. Lifestyle interventions (i.e., physical activity and nutrition) are the cornerstone of T2DM management and prevention. Prior research attests to the health benefits of consuming nuts, which have a substantial amount of mono- and polyunsaturated fatty acids, for individuals at risk for or with T2DM, and walnuts appear to be particularly promising. Walnuts are rich in nutrients, minerals, antioxidants, and vitamins that can contribute to improved cardio-metabolic risk factors in individuals at risk for or with T2DM. This review assesses the cardio-metabolic benefits of walnuts in T2DM. The authors’ review indicates that the reported effects of walnuts on glycaemic control have been inconclusive, with several studies showing association with improved glycaemic control while others show no effect. Despite their high energy density and potential to contribute to weight gain, the authors’ review suggests that walnuts can contribute to satiety without association with weight gain. This review also suggests that walnut consumption has been associated with improved low-density lipoprotein cholesterol levels and endothelial function but has not been associated with blood pressure improvement. Meta-analyses are warranted to quantitatively assess impact of walnut consumption on these cardio-metabolic risk factors in T2DM.

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Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa087 ◽

2020 ◽

Cited By ~ 1

Author(s):

Santosh Lamichhane ◽

Alex M Dickens ◽

Partho Sen ◽

Heikki Laurikainen ◽

Faith Borgan ◽

...

Keyword(s):

At Risk ◽

Weight Gain ◽

High Risk ◽

Psychotic Disorders ◽

First Episode Psychosis ◽

Molecular Signature ◽

First Episode ◽

Baseline Serum ◽

Average Life Span ◽

Episode Psychosis

Abstract Patients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic comorbidities. There is an unmet public health need to identify individuals with psychotic disorders who have a high risk of rapid weight gain and who are at risk of developing metabolic complications. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 healthy controls (CTR), 44 first-episode psychosis (FEP) patients, and 22 individuals at clinical high risk (CHR) for psychosis, from 2 study centers (Turku, Finland and London, UK). Baseline serum samples were analyzed using lipidomics, and body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols (TGs) with low double-bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of 2 TGs (TG[48:0] and TG[45:0]) was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic comorbidities.

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Self-efficacy beliefs and eating behavior in adolescent girls at-risk for excess weight gain and binge eating disorder

International Journal of Eating Disorders ◽

10.1002/eat.22160 ◽

2013 ◽

Vol 46 (7) ◽

pp. 663-668 ◽

Cited By ~ 21

Author(s):

Deborah R. Glasofer ◽

David A.F. Haaga ◽

Louise Hannallah ◽

Sara E. Field ◽

Merel Kozlosky ◽

...

Keyword(s):

At Risk ◽

Eating Disorder ◽

Weight Gain ◽

Binge Eating ◽

Eating Behavior ◽

Adolescent Girls ◽

Binge Eating Disorder ◽

Efficacy Beliefs ◽

Excess Weight ◽

Excess Weight Gain

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Trajectories of Change in Body Weight During Inpatient Treatment for Anorexia Nervosa

Journal of the American Psychiatric Nurses Association ◽

10.1177/1078390317726142 ◽

2017 ◽

Vol 24 (4) ◽

pp. 306-313 ◽

Cited By ~ 3

Author(s):

Karen M. Jennings ◽

Matthew Gregas ◽

Barbara Wolfe

Keyword(s):

At Risk ◽

Body Weight ◽

Anorexia Nervosa ◽

Weight Gain ◽

Inpatient Treatment ◽

Response Patterns ◽

Treatment Resistant ◽

Trajectory Modeling ◽

Weight Restoration ◽

Trajectories Of Change

BACKGROUND: Identifying distinct trajectories of change in body weight during inpatient treatment for anorexia nervosa (AN) may provide knowledge about the process of weight restoration and may help detect optimal body weight response patterns among individuals who are at risk for not achieving weight restoration or leaving treatment prematurely. OBJECTIVE: This study explored the extent to which distinct trajectories of change in body weight existed among individuals during inpatient treatment for AN. DESIGN: Group-based trajectory modeling was used to identify distinct trajectories of change in body weight among 500 individuals receiving inpatient treatment for AN. RESULTS: Four distinct trajectories were identified: weight gain ( n = 197), treatment resistant ( n = 177), weight plateau ( n = 82), and weight fluctuate ( n = 44). CONCLUSION: Clinically, it is important to consider the heterogeneity of changes in body weight during inpatient treatment to help guide interventions and outcomes.

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