scholarly journals Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions

PROTEOMICS ◽  
2013 ◽  
Vol 13 (9) ◽  
pp. 1428-1436 ◽  
Author(s):  
David A. Drew ◽  
Thomas Devers ◽  
Nicole Horelik ◽  
Shi Yang ◽  
Michael O'Brien ◽  
...  
Keyword(s):  
Receptor Kinase ◽  
Translational Activation ◽  
Extracellular Receptor Kinase

Abstract 3997: Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic aberrant crypt foci.

2013 ◽  
Author(s):  
David A. Drew ◽  
Thomas Devers ◽  
Nicole Horelik ◽  
Shi Yang ◽  
Michael O'Brien ◽  
...  
Keyword(s):  
Aberrant Crypt Foci ◽  
Receptor Kinase ◽  
Translational Activation ◽  
Extracellular Receptor Kinase

Colony-stimulating factor-1–induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages

Blood ◽  
2009 ◽  
Vol 114 (17) ◽  
pp. 3633-3641 ◽  
Author(s):  
Arnaud Jacquel ◽  
Naïma Benikhlef ◽  
Jérôme Paggetti ◽  
Najoua Lalaoui ◽  
Leslie Guery ◽  
...  
Keyword(s):  
Caspase 8 ◽  
Receptor Kinase ◽  
Colony Stimulating Factor ◽  
Caspase Activation ◽  
Phosphatidylinositol 3 Kinase ◽  
Macrophage Differentiation ◽  
Akt Activation ◽  
Stimulating Factor ◽  
Extracellular Receptor Kinase ◽  
Phosphatidylinositol 3

Abstract The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within minutes the phosphorylation of its cytoplasmic tyrosine residues and the activation of multiple signaling complexes. Caspase-8 and -3 are activated at day 2 to 3 and contribute to macrophage differentiation, for example, through cleavage of nucleophosmin. Here, we show that the phosphatidylinositol-3 kinase and the downstream serine/threonine kinase AKT connect CSF-1R activation to caspase-8 cleavage. Most importantly, we demonstrate that successive waves of AKT activation with increasing amplitude and duration are required to provoke the formation of the caspase-8–activating molecular platform. CSF-1 and its receptor are both required for oscillations in AKT activation to occur, and expression of a constitutively active AKT mutant prevents the macrophage differentiation process. The extracellular receptor kinase 1/2 pathway is activated with a coordinated oscillatory kinetics in a CSF-1R–dependent manner but plays an accessory role in caspase activation and nucleophosmin cleavage. Altogether, CSF-1 stimulation activates a molecular clock that involves phosphatidylinositol-3 kinase and AKT to promote caspase activation. This oscillatory signaling pathway, which is coordinated with extracellular receptor kinase 1/2 oscillatory activation, involves CSF-1 and CSF-1R and controls the terminal differentiation of macrophages.

scholarly journals Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation

Neuroscience ◽  
2010 ◽  
Vol 169 (2) ◽  
pp. 843-854 ◽  
Author(s):  
R.J. Horvath ◽  
R.P. Landry ◽  
E.A. Romero-Sandoval ◽  
J.A. DeLeo
Keyword(s):  
Postoperative Pain ◽  
Morphine Tolerance ◽  
Receptor Kinase ◽  
Kinase Phosphorylation ◽  
Extracellular Receptor Kinase

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation

Neuroreport ◽  
1999 ◽  
Vol 10 (11) ◽  
pp. 2411-2415 ◽  
Author(s):  
George Perry ◽  
Hanno Roder ◽  
Akihiko Nunomura ◽  
Atsushi Takeda ◽  
Avi L. Friedlich ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer Disease ◽  
Receptor Kinase ◽  
Extracellular Receptor Kinase

947: Chemopreventive Effects of COX-2 Inhibitor and Epidermal Growth Factor (EGF)-Receptor Kinase Inhibitor on Rat Urinary Bladder Tumorigenesis

2004 ◽  
Vol 171 (4S) ◽  
pp. 251-251
Author(s):  
Kazunori Hattori ◽  
Katsuyuki Iida ◽  
Akira Johraku ◽  
Sadamu Tsukamoto ◽  
Taeko Asano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Urinary Bladder ◽  
Egf Receptor ◽  
Kinase Inhibitor ◽  
Receptor Kinase ◽  
Rat Urinary Bladder ◽  
Epidermal Growth ◽  
Cox 2
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