Dual Stimuli‐Responsive Self‐Assembly Behavior of a Tailor‐Made ABC‐Type Amphiphilic Tri‐Block Copolymer

Organic/inorganic hybrid materials based upon stimuli-responsive copolymers have attracted an inceasing attention. Compared with the polymeric materials, these hybrid materials can form aggregates in aqueous solution with much more stable shape-persistance due to the inorganic structure, which facilitate the mass delivery and long-term life. A novel hybrid material based on a new reactive block copolymer, poly(ethylene oxide)-block-poly{3-(trimethoxysilyl)propyl methacrylate-co-N-isopropylacrylamide-co-6-[4-(4-methoxyphenylazo)phenoxy]hexyl methacrylate} [PEO-P(TMSPMA-NIPAM-AzoMA)] was synthesized via atom transfer radical polymerization (ATRP). The vesicles were obtained by self-assembly of the resulting block copolymer in a selective solvent, and then the PTMSPMA block was subjected to hydrolysis and polycondensation reaction to fix vesicle wall in the presence of triethylamine as a catalyst. The photo- and thermo- dual-responsive properties of the vesicles were investigated.

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pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.16.168 ◽

2020 ◽

Vol 16 ◽

pp. 2017-2025

Author(s):

Goutam Ghosh ◽

Gustavo Fernández

Keyword(s):

Self Assembly ◽

Ph Value ◽

Secondary Structures ◽

Random Coil ◽

Conformational Transformation ◽

Stimuli Responsive ◽

Responsive Materials ◽

Force Microscopy ◽

Assembly Behavior ◽

Novel Drug

Peptide-based biopolymers represent highly promising biocompatible materials with multiple applications, such as tailored drug delivery, tissue engineering and regeneration, and as stimuli-responsive materials. Herein, we report the pH- and concentration-dependent self-assembly and conformational transformation of the newly synthesized octapeptide PEP-1. At pH 7.4, PEP-1 forms β-sheet-rich secondary structures into fractal-like morphologies, as verified by circular dichroism (CD), Fourier-transform infrared (FTIR) spectroscopy, thioflavin T (ThT) fluorescence spectroscopy assay, and atomic force microscopy (AFM). Upon changing the pH value (using pH 5.5 and 13.0), PEP-1 forms different types of secondary structures and resulting morphologies due to electrostatic repulsion between charged amino acids. PEP-1 can also form helical or random-coil secondary structures at a relatively low concentration. The obtained pH-sensitive self-assembly behavior of the target octapeptide is expected to contribute to the development of novel drug nanocarrier assemblies.

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A facile strategy for manipulating micellar size and morphology through intramolecular cross-linking of amphiphilic block copolymers

Polymer Chemistry ◽

10.1039/c7py00646b ◽

2017 ◽

Vol 8 (23) ◽

pp. 3647-3656 ◽

Cited By ~ 7

Author(s):

Ryoto Tanaka ◽

Kodai Watanabe ◽

Takuya Yamamoto ◽

Kenji Tajima ◽

Takuya Isono ◽

...

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Self Assembly ◽

Amphiphilic Block Copolymers ◽

Amphiphilic Block Copolymer ◽

Cross Linking ◽

Micellar Size ◽

System P ◽

Assembly Behavior ◽

Size And Morphology

The effect of intramolecular cross-linking on aqueous self-assembly behavior was systematically investigated based on an amphiphilic block copolymer system.

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Temperature and Photo Dual‐Stimuli Responsive Block Copolymer Self‐Assembly Micelles for Cellular Controlled Drug Release

Macromolecular Bioscience ◽

10.1002/mabi.202000291 ◽

2020 ◽

pp. 2000291

Author(s):

Zi‐Hao Zhou ◽

Jian‐Guo Zhang ◽

Qing Chen ◽

Yan‐Ling Luo ◽

Feng Xu ◽

...

Keyword(s):

Block Copolymer ◽

Drug Release ◽

Self Assembly ◽

Controlled Drug Release ◽

Stimuli Responsive

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Correction: Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties

RSC Advances ◽

10.1039/c8ra90036a ◽

2018 ◽

Vol 8 (32) ◽

pp. 17878-17878

Author(s):

Yiting Xu ◽

Jie Cao ◽

Qi Li ◽

Jilu Li ◽

Kaiwei He ◽

...

Keyword(s):

Self Assembly ◽

Amphiphilic Copolymers ◽

Stimuli Responsive ◽

Assembly Behavior

Correction for ‘Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties’ by Yiting Xu et al., RSC Adv., 2018, 8, 16103–16113.

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Synthesis of poly(styrene-b-4-(tert-butyldimethylsiloxy)styrene) block copolymers and characterization of their self-assembled patterns

Molecular Systems Design & Engineering ◽

10.1039/c7me00085e ◽

2017 ◽

Vol 2 (5) ◽

pp. 589-596 ◽

Cited By ~ 2

Author(s):

Yoon Hyung Hur ◽

Seung Won Song ◽

Jimmy Mays ◽

YongJoo Kim ◽

Beom-Goo Kang ◽

...

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Self Assembly ◽

Self Assembled ◽

Assembly Behavior

Self-assembly behavior of poly(styrene-b-4-(tert-butyldimethylsiloxy)styrene) (PS-b-P4BDSS) block copolymer and the effect of polydispersity on self-assembled pattern quality.

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Self-Assembly Behavior of a Stimuli-Responsive Water-Soluble [60]Fullerene-Containing Polymer

Langmuir ◽

10.1021/la048826s ◽

2004 ◽

Vol 20 (20) ◽

pp. 8569-8575 ◽

Cited By ~ 39

Author(s):

S. Dai ◽

P. Ravi ◽

C. H. Tan ◽

K. C. Tam

Keyword(s):

Self Assembly ◽

Water Soluble ◽

Stimuli Responsive ◽

Assembly Behavior

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Fabrication and in situ functionalisation of mesoporous silica films by the physical entrapment of functional and responsive block copolymer structuring agents

Soft Matter ◽

10.1039/c9sm00872a ◽

2019 ◽

Vol 15 (40) ◽

pp. 8077-8083 ◽

Cited By ~ 2

Author(s):

Jessica C. Tom ◽

Christian Appel ◽

Annette Andrieu-Brunsen

Keyword(s):

Block Copolymer ◽

Mesoporous Silica ◽

Self Assembly ◽

Stimuli Responsive ◽

Silica Films ◽

Functional Block ◽

Evaporation Induced Self Assembly ◽

Physical Entrapment

Stimuli-responsive mesoporous silica films were prepared by evaporation-induced self-assembly through the physical entrapment of a functional block copolymer structuring agent, which simultaneously serves to functionalise the mesopore.

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Controlled nanogel and macrogel structures from self-assembly of a stimuli-responsive amphiphilic block copolymer

RSC Advances ◽

10.1039/c6ra03933b ◽

2016 ◽

Vol 6 (69) ◽

pp. 64791-64798 ◽

Cited By ~ 4

Author(s):

JianCheng Liu ◽

Christina Uhlir ◽

Parag K. Shah ◽

Fang Sun ◽

Jeffrey W. Stansbury

Keyword(s):

Block Copolymer ◽

Self Assembly ◽

Raft Polymerization ◽

Amphiphilic Block Copolymer ◽

Stimuli Responsive

RAFT polymerization was utilized to prepare an amphiphilic block copolymer containing both hydrophilic and hydrophobic segments.

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Synthesis and self-assembly behavior of pH-responsive star-shaped POSS-(PCL-P(DMAEMA-co-PEGMA))16 inorganic/organic hybrid block copolymer for the controlled intracellular delivery of doxorubicin

RSC Advances ◽

10.1039/c6ra09803g ◽

2016 ◽

Vol 6 (66) ◽

pp. 61630-61640 ◽

Cited By ~ 12

Author(s):

Lei Li ◽

Beibei Lu ◽

Qikui Fan ◽

Jianning Wu ◽

Lulu Wei ◽

...

Keyword(s):

Block Copolymer ◽

Self Assembly ◽

Tumor Tissue ◽

Intracellular Delivery ◽

Ph Responsive ◽

Acidic Microenvironment ◽

Organic Hybrid ◽

Intracellular Release ◽

Anti Cancer ◽

Assembly Behavior

Illustration of pH-responsive self-assembly of the star-shaped POSS-(PCL-P(DMAEMA-co-PEGMA))16 copolymer for the efficient intracellular release of anti-cancer drugs triggered by the acidic microenvironment inside the tumor tissue.

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