Changes in supportive care needs after first-line treatment for ovarian cancer: identifying care priorities and risk factors for future unmet needs

Abstract Background Benefit of carboplatin and dose-dense weekly paclitaxel (ddCT) in first line treatment of ovarian cancer patients has been different in Western and Asian studies. In the present study we compare progression-free survival (PFS) of ddCT to three-weekly carboplatin and paclitaxel (CT) in first-line treatment of ovarian carcinoma in a single institution in a Western population. Materials and methods We conducted a retrospective review of medical records from patients with ovarian carcinoma treated in a tertiary cancer center from 2007 to 2018. All patients treated with ddCT or CT in the first-line setting were included. Patients who received first-line bevacizumab were not included. PFS and overall survival (OS) were compared in a propensity score-matched cohort to address selection bias. Patients were matched according to age, ECOG performance status, CA 125, FIGO stage, residual disease, and histological subtype, in a 1:2 ratio. Results Five hundred eighty-eight patients were eligible for propensity score matching, the final cohort consisted of 69 patients treated with ddCT and 138 CT group. Baseline characteristics were well-balanced. After a median follow-up of 65.1 months, median PFS was 29.3 vs 20.0 months, favouring ddCT treatment (p = 0.035). In the multivariate cox regression ddCT showed a 18% lower risk of progression (HR 0.82, 95% CI 0.68–0.99, p = 0.04). Overall survival data is immature, but suggested better outcomes for ddCT (not reached versus 78.8 months; p = 0.07). Conclusion Our retrospective study has shown superior PFS of ddCT over CT regimen in first-line treatment of ovarian carcinoma in a Western population not treated with bevacizumab.

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Gemcitabine combined with cisplatin as first-line treatment in patients 60 years or older with epithelial ovarian cancer: a phase II study

International Journal of Gynecological Cancer ◽

10.1046/j.1525-1438.2003.13039.x ◽

2003 ◽

Vol 13 (2) ◽

pp. 130-137 ◽

Cited By ~ 9

Author(s):

T. Bauknecht ◽

A. Hefti ◽

G. Morack ◽

C. Villena-Heinsen ◽

D. Wallwiener ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Phase Ii ◽

Phase Ii Study ◽

Line Treatment ◽

First Line ◽

First Line Treatment

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Patients' Supportive Care Needs Beyond the End of Cancer Treatment: A Prospective, Longitudinal Survey

Journal of Clinical Oncology ◽

10.1200/jco.2009.22.5151 ◽

2009 ◽

Vol 27 (36) ◽

pp. 6172-6179 ◽

Cited By ~ 354

Author(s):

Jo Armes ◽

Maggie Crowe ◽

Lynne Colbourne ◽

Helen Morgan ◽

Trevor Murrells ◽

...

Keyword(s):

Negative Affect ◽

Supportive Care ◽

Unmet Needs ◽

Unmet Need ◽

Hormone Treatment ◽

Longitudinal Survey ◽

Supportive Care Needs ◽

Fear Of Recurrence ◽

Care Needs ◽

Prospective Longitudinal

Purpose To estimate prevalence and severity of patients' self-perceived supportive care needs in the immediate post-treatment phase and identify predictors of unmet need. Patients and Methods A multicenter, prospective, longitudinal survey was conducted. Sixty-six centers recruited patients for 12 weeks. Patients receiving treatment for the following cancers were recruited: breast, prostate, colorectal, and gynecologic cancer and non-Hodgkin's lymphoma. Measures of supportive care needs, anxiety and depression, fear of recurrence, and positive and negative affect were completed at the end of treatment (T0) and 6 months later (T1). Results Of 1,850 patients given questionnaire packs, 1,425 (79%) returned questionnaires at T0, and 1,152 (62%) returned questionnaires at T1. Mean age was 61 years; and most respondents were female (69%) and had breast cancer (57%). Most patients had no or few moderate or severe unmet supportive care needs. However, 30% reported more than five unmet needs at baseline, and for 60% of these patients, the situation did not improve. At both assessments, the most frequently endorsed unmet needs were psychological needs and fear of recurrence. Logistic regression revealed several statistically significant predictors of unmet need, including receipt of hormone treatment, negative affect, and experiencing an unrelated significant event between assessments. Conclusion Most patients do not express unmet needs for supportive care after treatment. Thirty percent reported more than five moderate or severe unmet needs at both assessments. Unmet needs were predicted by hormone treatment, negative mood, and experiencing a significant event. Our results suggest that there is a proportion of survivors with unmet needs who might benefit from the targeted application of psychosocial resources.

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First line treatment with carboplatin-paclitaxel-bevacizumab in ovarian cancer: retrospective review of a single institute experience

Annals of Oncology ◽

10.1093/annonc/mdx429.006 ◽

2017 ◽

Vol 28 ◽

pp. vi71 ◽

Cited By ~ 1

Author(s):

A. Bologna ◽

A. Garcia-Arias ◽

L. Baldi ◽

A. Berselli ◽

M. Pagano ◽

...

Keyword(s):

Ovarian Cancer ◽

Retrospective Review ◽

Line Treatment ◽

First Line ◽

First Line Treatment

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Assessment of Needs of Hospitalized Cancer Patients with Advanced Cancer

Global Journal of Health Science ◽

10.5539/gjhs.v9n6p184 ◽

2016 ◽

Vol 9 (6) ◽

pp. 184

Author(s):

Theocharis I. Konstantinidis ◽

George Samonis ◽

Pavlos Sarafis ◽

Anastas Philalithis

Keyword(s):

Supportive Care ◽

Psychometric Properties ◽

Advanced Cancer ◽

Unmet Needs ◽

Supportive Care Needs ◽

University Hospital ◽

Validity And Reliability ◽

Treatment Needs ◽

Care Needs ◽

Optimal Care

BACKGROUND: Needs assessment of patients with advanced cancer (ACPs) is essential for optimal care. This study evaluated the psychometric properties of the Needs Evaluation Questionnaire (NEQ) and assessed the supportive care needs of hospitalized ACPs with solid tumors.METHODS: The validated Greek version of the NEQ along with demographic and clinical data of 95 consecutive breast, colon and lung ACPs hospitalized in the University Hospital of Heraklion, Crete, Greece, were used to assess their supportive care needs. The NEQ score was subsequently rescaled to 0-100.RESULTS: NEQ displayed adequate psychometric properties in validity and reliability tests. The average number of needs reported was 8.4(4.1). Female and younger patients reported a higher score of unmet needs than their male (40.3 versus 30.0, p=0.005) and elder (40.1 versus 29.2, p=0.001) counterparts. Patients reported higher needs in receiving information about their future (73.7%), treatments (56.8%), examinations (51.6%) and for the need "to speak with people who had the same experience" (53.7%). In contrast, lower scores were observed in the assistance and treatments needs regarding intimacy (11.6%), "better attention from nurses" (15.8%), "more help with eating, dressing, and going to the bathroom" (18.9%). Lung ACPs reported more assistance and treatment needs than colon and breast ACPs (p<0.05).CONCLUSIONS: ACPs reported many unmet needs, mainly informational, that were related to gender, age, and type of cancer. NEQ is a useful tool in everyday clinical practice for obtaining information for supportive care needs. Health care personnel has to address these needs for implementing effective patient-centered care.

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