Colorectal cancer patients can be advocates for colorectal cancer screening for their siblings: A study on siblings' perspectives

2020 ◽  
Vol 29 (12) ◽  
pp. 2028-2032
Author(s):  
Ker‐Kan Tan ◽  
Tian‐Zhi Lim ◽  
Emily Chew ◽  
Wen‐Min Chow ◽  
Gerald Choon‐Huat Koh
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Colorectal Cancer Screening ◽  
Colorectal Cancer Patients

scholarly journals Colorectal Cancer Screening Among First-Degree Relatives of Colorectal Cancer Patients: Benefits and Barriers

2009 ◽  
Vol 16 (8) ◽  
pp. 2092-2100 ◽  
Author(s):  
Lloyd A. Mack ◽  
Linda S. Cook ◽  
Walley J. Temple ◽  
Linda E. Carlson ◽  
Robert J. Hilsden ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Colorectal Cancer Screening ◽  
First Degree Relatives ◽  
Colorectal Cancer Patients

Blood-based screening for methylation changes in colorectal cancer patients using novel nanotechnologies.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 384-384
Author(s):  
Nita Ahuja ◽  
Ruby Kwak ◽  
Brian Keeley ◽  
Alejandro Stark ◽  
Angela Anna Guzzetta ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Methylation Status ◽  
High Sensitivity ◽  
Single Copy ◽  
Tissue Samples ◽  
Methylation Frequency ◽  
Colorectal Cancer Patients ◽  
Cancer Tissues

384 Background: Identification of blood-based biomarkers for cancer screening is essential in order to develop novel and minimally invasive methods for colorectal cancer screening. Our lab has successfully applied a novel nanotechnology that allows us to detect and amplify a single tumor DNA fragment in a plasma sample. This DNA is tested for methylation of several genes including TFPI2 which has shown to be highly sensitive and specific for the detection colorectal cancer in stool. Methods: Whole blood was obtained from 18 colorectal cancer patients and plasma was isolated. Plasma was processed using Methylation On Beads nanotechnology (MOB) and bisulfate treated. Methylation status was determined via quantitative PCR method. Results: Two genes, TFPI2 and IGFBP3, were detected with a high sensitivity. TFPI2, demonstrated a methylation frequency of 94.4%, which is concordant with the TFPI2 methylation frequency of 99% in primary colorectal cancer tissues. IGFBP3 showed the methylation frequency of 61.1%, which corresponds with the methylation frequency of 52% in retrospective colorectal cancer tissues in previous studies. Quantification using standard curves indicated a single copy level of DNA found in plasma. Conclusions: Blood-based screening is challenging due to extremely low quantities of circulating DNA in blood. Utilizing a novel nanotechnology that detects DNA at a single copy level, the methylation changes in colorectal cancer were successfully detected in plasmas at similar frequencies as in tissue samples. This study has demonstrated the feasablility and applicability to blood-based screening. Future studies will focus on improving the sensitivity and determining the specificity of this method.

Promoting Cancer Screening among the First-Degree Relatives of Breast and Colorectal Cancer Patients: The Design of Two Randomized Trials

1999 ◽  
Vol 28 (3) ◽  
pp. 229-242 ◽  
Author(s):  
Alfred C. Marcus ◽  
Dennis Ahnen ◽  
Gary Cutter ◽  
Ned Calonge ◽  
Sarah Russell ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Randomized Trials ◽  
First Degree Relatives ◽  
Colorectal Cancer Patients

Factors Affecting Cancer Prevention Behaviors and Cancer Screening in First-Degree Relatives of Breast and Colorectal Cancer Patients in Korea: A Cross-Sectional Study

2021 ◽  
pp. RTNP-D-20-00113
Author(s):  
Yoonjung Lee ◽  
Kyunghwa Lee ◽  
Sanghee Kim
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Cancer Patients ◽  
Cancer Worry ◽  
Cancer Knowledge ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Colorectal Cancer Patients

BackgroundFirst-degree relatives (FDRs) of cancer patients have a high risk of cancer due to a similar lifestyle and genetic predisposition. However, previous studies rarely examined the level of cancer prevention behaviors and screening and affecting factors in cancer patients’ FDRs.PurposeThis study aimed to describe the levels of cancer knowledge, attitudes toward cancer, cancer worry, perceived cancer risk, and cancer prevention behaviors and cancer screening in FDRs of breast and colorectal cancer patients. Moreover, it sought to identify factors affecting cancer prevention behavior and cancer screening.MethodsA cross-sectional, descriptive correlational design was used. The study enrolled 138 FDRs of breast and colorectal cancer patients. Participants completed self-administered questionnaires at a tertiary hospital in Seoul, Korea. Descriptive statistics, frequencies, chi-square test, independent t test, one-way analysis of variance (ANOVA), Pearson’s correlation, multiple regression, and logistic regression were performed for data analysis.ResultsThe levels of perceived cancer risk, cancer knowledge, attitude toward cancer, and cancer prevention behaviors were moderate, while the level of cancer worry was high. Ninety-two participants reported having undergone cancer screenings, but the types of screening were not associated with their family history. Age, gender, and attitude toward cancer affected cancer prevention behaviors. The cancer screening rate was higher in older participants, in women, and in patients’ FDRs with a longer cancer diagnosis.Implications for PracticeAttitude was the modifiable factor for cancer prevention behaviors. Nurse-led educational and counseling interventions should be developed to improve attitude toward cancer among FDRs of cancer patients.

Spillover improved survival in non-invited patients of the colorectal cancer screening programme

2017 ◽  
Vol 25 (3) ◽  
pp. 134-140 ◽  
Author(s):  
Joonas Miettinen ◽  
Nea Malila ◽  
Matti Hakama ◽  
Janne Pitkäniemi
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Randomized Clinical Trials ◽  
Spillover Effect ◽  
Effect Estimate ◽  
Cancer Registry Data ◽  
Percentage Points ◽  
Cancer Screening Programme ◽  
Colorectal Cancer Patients

Objectives In colorectal cancer screening, randomized clinical trials have shown a 16% mean reduction in colorectal cancer mortality, but the Finnish randomized health services study showed no effect. We quantified spillover (the total indirect effect caused by the programme on the non-invited) and corrected the effectiveness estimate of the Finnish programme. Methods We retrieved from the Finnish Cancer Registry data on all non-invited colorectal cancer patients diagnosed in 1999–2013 in municipalities that adopted screening ( n = 18,948). Patients were stratified by three 5-year diagnostic periods and two calendar periods of programme adoption in the municipality of residence. Follow-up ended on 31 December 2013. We measured the spillover effect in patient survival, based on differences of adjusted estimates of the colorectal cancer-related hazard of death between pairs of consecutive diagnostic periods. Results The spillover effect was estimated as 9 percentage points (95% confidence interval: −1 to 19 percentage points). It was 13 percentage points in men (−1 to 26 percentage points) and 5 percentage points in women (−9 to 20 percentage points). The corrected effect estimate of implementing screening in Finland was 5 percentage points. Conclusions The corrected Finnish effectiveness estimate was consistent with estimates from randomized trials. Indirect effects (spillover) bias the invitee–control contrast. In this case, spillover was an inherent benefit of the Finnish programme.

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