Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer

e16166 Background: Epidemiologic studies suggest that low selenium levels are associated with an increased incidence of prostate cancer, although results are conflicting. We examined the association between serum selenium levels and risk of prostate cancer in men who received a prostate biopsy in our hospital. Methods: Our prospective study included 82 patients who received a prostate biopsy based on elevated PSA levels over 4.0ng/ml. Serum from each patient was sampled to determine the selenium level at the time of biopsy. Of these, 47 patients were diagnosed with prostate cancer (case group) and no malignant lesions in the biopsy specimen were detected in the remains, 35 patients (control group). Results: The mean serum selenium levels in the case and control group were 120.4 (SD, 14.4) ng/mL and 118.5 (SD, 16.1) ng/mL, respectively (p = 0.588). Serum selenium levels at biopsy were not associated with risk of prostate cancer diagnosis. In the case group, the mean serum selenium levels in patients diagnosed with 6 or less in Gleason score and 7 or more were 121.0 (SD, 9.9) ng/mL (n = 14) and 120.1 (SD, 16.1) ng/mL (n = 33), respectively (p = 0.851). Serum selenium levels at biopsy were not associated with Gleason score in the case group. An inverse association between serum selenium and PSA levels at biopsy was observed (p = 0.030). No correlation was observed between serum selenium level and age at biopsy. Conclusions: From this study, serum selenium level cannot predict the result of prostate biopsy. The inverse association between serum selenium and PSA levels may suggest that low selenium levels are associated with an increased incidence of prostate cancer. No significant financial relationships to disclose.

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Serum selenium levels and prostate cancer risk

Medicine ◽

10.1097/md.0000000000005944 ◽

2017 ◽

Vol 96 (5) ◽

pp. e5944 ◽

Cited By ~ 18

Author(s):

Zhigang Cui ◽

Dezhong Liu ◽

Chun Liu ◽

Gang Liu

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Prostate Cancer Risk ◽

Serum Selenium ◽

Serum Selenium Levels

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Should we routinely test for serum selenium levels in post-bariatric surgery patients?

Surgery for Obesity and Related Diseases ◽

10.1016/j.soard.2010.02.011 ◽

2010 ◽

Vol 6 (2) ◽

pp. 227

Author(s):

Mutaz Suyagh ◽

Peter Sedman ◽

Prashant Jain ◽

El-Naseer Salim ◽

Khaled Hamdan

Keyword(s):

Bariatric Surgery ◽

Serum Selenium ◽

Serum Selenium Levels ◽

Post Bariatric Surgery

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Alterations in serum selenium levels and their relation to troponin I in acute myocardial infarction

Molecular and Cellular Biochemistry ◽

10.1007/s11010-010-0555-x ◽

2010 ◽

Vol 345 (1-2) ◽

pp. 23-27 ◽

Cited By ~ 12

Author(s):

Barbara Kutil ◽

Petr Ostadal ◽

Jiri Vejvoda ◽

Jiri Kukacka ◽

Jana Cepova ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Troponin I ◽

Serum Selenium ◽

Serum Selenium Levels

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Serum Selenium Level and 10-Year Survival after Melanoma

Biomedicines ◽

10.3390/biomedicines9080991 ◽

2021 ◽

Vol 9 (8) ◽

pp. 991

Author(s):

Emilia Rogoża-Janiszewska ◽

Karolina Malińska ◽

Piotr Baszuk ◽

Wojciech Marciniak ◽

Róża Derkacz ◽

...

Keyword(s):

Selenium Level ◽

Serum Selenium ◽

Lower Survival Rate ◽

Treatment Regimens ◽

Melanoma Diagnosis ◽

Serum Selenium Levels ◽

Melanoma Prognosis ◽

Level I ◽

Low Selenium ◽

Serum Selenium Level

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.

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Comparison between preterm and full term neonatal cord selenium in correlation to maternal serum selenium levels

Egyptian Pediatric Association Gazette ◽

10.1016/j.epag.2018.10.001 ◽

2018 ◽

Vol 66 (4) ◽

pp. 96-99

Author(s):

Gihan M. Bebars ◽

Bothina A. Kamel ◽

Emad Allam

Keyword(s):

Maternal Serum ◽

Full Term ◽

Serum Selenium ◽

Serum Selenium Levels

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Serum selenium levels in liver diseases

Clinical Biochemistry ◽

10.1016/s0009-9120(82)96790-x ◽

1982 ◽

Vol 15 (6) ◽

pp. 281-283 ◽

Cited By ~ 40

Author(s):

Jan Aaseth ◽

Jan Alexander ◽

Yngvar Thomassen ◽

Jan P. Blomhoff ◽

Sverre Skrede

Keyword(s):

Liver Diseases ◽

Serum Selenium ◽

Serum Selenium Levels

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Association of Initial Low Serum Selenium Level with Infectious Complications and 30-Day Mortality in Multiple Trauma Patients

Nutrients ◽

10.3390/nu11081844 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1844 ◽

Cited By ~ 1

Author(s):

Soon Bo Choi ◽

Yun Tae Jung ◽

Jae Gil Lee

Keyword(s):

Multiple Trauma ◽

Selenium Deficiency ◽

Infectious Complications ◽

Selenium Level ◽

Trauma Patients ◽

Serum Selenium ◽

Serum Selenium Levels ◽

Multiple Trauma Patients ◽

Serum Selenium Level ◽

Low Serum

Low serum selenium levels are commonly observed in critically injured multiple trauma patients. This study aimed to identify the association between initial serum selenium levels and in-hospital infectious complications in multiple trauma patients. We retrospectively reviewed multiple trauma patients admitted between January 2015 and November 2017. We selected 135 patients whose serum selenium levels were checked within 48 h of admission. Selenium deficiency was defined as a serum selenium level <70 ng/mL. Survival analyses of selenium deficiency and 30-day mortality were performed. Multivariate logistic regression analysis was performed to identify the association between initial serum selenium level and in-hospital infectious complications. Thirty-day mortality (8.3% vs. 0.0%; p = 0.018) and incidence rates of pneumonia (66.7% vs. 28.3%; p < 0.001) and infectious complications (83.3% vs. 46.5%; p < 0.001) were higher in patients with selenium deficiency than in patients without selenium deficiency. Kaplan–Meier survival cures also showed similar results (log rank test, p = 0.021). Of 135 patients, 76 (56.3%) experienced at least one infectious complication during admission. High injury severity score (ISS, odds ratio (OR) 1.065, 95% confidence interval (CI) 1.024–1.108; p = 0.002) and selenium deficiency (OR 3.995, 95% CI 1.430–11.156; p = 0.008) increased the risk of in-hospital infectious complications in multiple trauma patients. Patients with selenium deficiency showed higher 30-day mortality and higher risks of pneumonia and infectious complications.

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