Speckle‐type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase

The Prostate ◽  
2019 ◽  
Vol 79 (8) ◽  
pp. 864-871 ◽  
Author(s):  
Xiaokun Gang ◽  
Lili Xuan ◽  
Xue Zhao ◽  
You Lv ◽  
Fei Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Lipid Accumulation ◽  
Fatty Acid Synthase ◽  
Cancer Growth

scholarly journals P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth

Oncotarget ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 15135-15149 ◽  
Author(s):  
Xiaokun Gang ◽  
Yinhui Yang ◽  
Jian Zhong ◽  
Kui Jiang ◽  
Yunqian Pan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fatty Acid Synthase ◽  
Cancer Growth

Inhibitors of Fatty Acid Synthase for Prostate Cancer

2012 ◽  
Author(s):  
Steven J. Kridel
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthase

Fatty Acid Synthase Activity as a Target for c-Met Driven Prostate Cancer

2013 ◽  
Author(s):  
David T. Coleman
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthase

Inhibitors of Fatty Acid Synthase for Prostate Cancer. Revision

2013 ◽  
Author(s):  
Steven J. Kridel
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthase

scholarly journals Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival

2010 ◽  
Vol 28 (25) ◽  
pp. 3958-3964 ◽  
Author(s):  
Paul L. Nguyen ◽  
Jing Ma ◽  
Jorge E. Chavarro ◽  
Matthew L. Freedman ◽  
Rosina Lis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Fatty Acid ◽  
Body Mass ◽  
Fatty Acid Synthase ◽  
Prostate Cancer Risk ◽  
De Novo Lipogenesis ◽  
Variant Allele ◽  
Specific Mortality ◽  
Tumor Expression

Purpose Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI). Methods In a prospective nested case-control study of 1,331 white patients with PCa and 1,267 age-matched controls, we examined associations of five common SNPs within FASN (and 5 kb upstream/downstream, R2 > 0.8) with PCa incidence and, among patients, PCa-specific death and tested for an interaction with BMI. Survival analyses were repeated for tumor FASN expression (n = 909). Results Four of the five SNPs were associated with lethal PCa. SNP rs1127678 was significantly related to higher BMI and interacted with BMI for both PCa risk (Pinteraction = .004) and PCa mortality (Pinteraction = .056). Among overweight men (BMI ≥ 25 kg/m2), but not leaner men, the homozygous variant allele carried a relative risk of advanced PCa of 2.49 (95% CI, 1.00 to 6.23) compared with lean men with the wild type. Overweight patients carrying the variant allele had a 2.04 (95% CI, 1.31 to 3.17) times higher risk of PCa mortality. Similarly, overweight patients with elevated tumor FASN expression had a 2.73 (95% CI, 1.05 to 7.08) times higher risk of lethal PCa (Pinteraction = .02). Conclusion FASN germline polymorphisms were significantly associated with risk of lethal PCa. Significant interactions of BMI with FASN polymorphisms and FASN tumor expression suggest FASN as a potential link between obesity and poor PCa outcome and raise the possibility that FASN inhibition could reduce PCa-specific mortality, particularly in overweight men.

Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride

The Prostate ◽  
2007 ◽  
Vol 67 (10) ◽  
pp. 1111-1120 ◽  
Author(s):  
Lucy J. Schmidt ◽  
Karla V. Ballman ◽  
Donald J. Tindall
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Fatty Acid Synthase ◽  
Prostate Cancer Cells

High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB

2005 ◽  
Vol 206 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Tine Van de Sande ◽  
Tania Roskams ◽  
Evelyne Lerut ◽  
Steven Joniau ◽  
Hein Van Poppel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Nuclear Localization ◽  
Fatty Acid Synthase ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
High Level Expression ◽  
High Level ◽  
Cancer Tissues

scholarly journals Emerging Therapeutic Activity of Davallia formosana on Prostate Cancer Cells through Coordinated Blockade of Lipogenesis and Androgen Receptor Expression

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 914
Author(s):  
Po-Fan Hsieh ◽  
Wen-Ping Jiang ◽  
Shih-Yin Huang ◽  
Praveenkumar Basavaraj ◽  
Jin-Bin Wu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Androgen Receptor ◽  
Molecular Basis ◽  
Fatty Acid Synthase ◽  
Specific Antigen ◽  
Receptor Expression ◽  
Migration And Invasion ◽  
Therapeutic Activity ◽  
Castration Resistant

Background: Prostate cancer (PCa) is the most prevalent malignancy diagnosed in men in Western countries. There is currently no effective therapy for advanced PCa aggressiveness, including castration-resistant progression. The aim of this study is to evaluate the potential efficacy and determine the molecular basis of Davallia formosana (DF) in PCa. Methods: LNCaP (androgen-sensitive) and C4-2 (androgen-insensitive/castration-resistant) PCa cells were utilized in this study. An MTT-based method, a wound healing assay, and the transwell method were performed to evaluate cell proliferation, migration, and invasion. Intracellular fatty acid levels and lipid droplet accumulation were analyzed to determine lipogenesis. Moreover, apoptotic assays and in vivo experiments were conducted. Results: DF ethanol extract (DFE) suppressed proliferation, migration, and invasion in PCa cells. DFE attenuated lipogenesis through inhibition of the expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FASN). Moreover, DFE decreased androgen receptor (AR) and prostate-specific antigen (PSA) expression in PCa cells. We further showed the potent therapeutic activity of DFE by repressing the growth and leading to apoptosis of subcutaneous C4-2 tumors in a xenograft mouse model. Conclusions: These data provide a new molecular basis of DFE in PCa cells, and co-targeting SREBP-1/FASN/lipogenesis and the AR axis by DFE could be employed as a novel and promising strategy for the treatment of PCa.

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

2011 ◽  
Vol 47 (3) ◽  
pp. 420-427 ◽  
Author(s):  
Daniele Campa ◽  
Anika Hüsing ◽  
Jenny Chang-Claude ◽  
Lucie Dostal ◽  
Heiner Boeing ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Genetic Variability ◽  
Cancer Risk ◽  
Fatty Acid Synthase ◽  
Prostate Cancer Risk ◽  
Prospective Investigation

Effects of Viola mandshurica on Atherosclerosis and Hepatic Steatosis in ApoE−∕− via the AMPK Pathway

2017 ◽  
Vol 45 (04) ◽  
pp. 757-772 ◽  
Author(s):  
Sun Haeng Park ◽  
Yoon-Young Sung ◽  
Kyoung jin Nho ◽  
Dong Sun Kim ◽  
Ho Kyoung Kim
Keyword(s):  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Lipid Accumulation ◽  
Fatty Acid Synthase ◽  
Inflammatory Responses ◽  
Water Extract ◽  
Intercellular Adhesion Molecule ◽  
Ampk Pathway

Atherosclerosis was previously thought to be a disease that primarily involves lipid accumulation in the arterial wall. In this report, we investigated the effect of Viola mandshurica W. Becker (V. mandshurica) water extract on atherosclerosis in apolipoprotein E deficient (ApoE[Formula: see text]) mice. The administration of V. mandshurica to high-fat diet-fed mice reduced body weight, liver weight, and serum levels of lipids (total cholesterol, low-density lipoprotein-cholesterol, triglycerides), glucose, alanine transaminase, and aspartate transaminase. Histopathologic analyses of the aorta and liver revealed that V. mandshurica attenuated atherosclerotic lesions and reduced lipid accumulation, inflammatory responses and fatty acid synthesis. V. mandshurica also increased phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), thereby reducing acetyl-CoA carboxylase (ACC) in liver tissue and inhibiting sterol regulatory element-binding protein 1c (SREBP-1c). V. mandshurica reduced protein expression levels of adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin) as well as ACC, fatty acid synthase, and SREBP-1c. In addition, quantitative analysis of V. mandshurica by high-performance liquid chromatography revealed the presence of esculetin and scopoletin. Esculetin and scopoletin reduced adhesion molecules in human aortic smooth muscle cells. Our results indicate that the anti-atherosclerotic effects of V. mandshurica may be associated with activation of the AMPK pathway. Therefore, AMPK-dependent phosphorylation of SREBP-1c by V. mandshurica may be an effective therapeutic strategy for combatting atherosclerosis and hepatic steatosis.

Sign in / Sign up

Export Citation Format

Share Document