Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study

2004 ◽  
Vol 18 (12) ◽  
pp. 996-999 ◽  
Author(s):  
S. Bolkent ◽  
R. Yanardag ◽  
O. Ozsoy-Sacan ◽  
O. Karabulut-Bulan
Toxicology ◽  
2002 ◽  
Vol 170 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Hamdy A Mansour ◽  
Al-Sayeda A Newairy ◽  
M.I Yousef ◽  
S.A Sheweita

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5255
Author(s):  
Gamal A. Soliman ◽  
Rehab F. Abdel-Rahman ◽  
Hanan A. Ogaly ◽  
Hassan N. Althurwi ◽  
Reham M. Abd-Elsalam ◽  
...  

More than 90% of diabetic patients suffer from sexual dysfunction, including diminished sperm count, sperm motility, and sperm viability, and low testosterone levels. The effects of Momordica charantia (MC) were studied by estimating the blood levels of insulin, glucose, glycosylated hemoglobin (HbA1c), testosterone (TST), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in diabetic rats treated with 250 and 500 mg/kg b.w. of the total extract. Testicular antioxidants, epididymal sperm characteristics, testicular histopathology, and lesion scoring were also investigated. Testicular mRNA expression of apoptosis-related markers such as antiapoptotic B-cell lymphoma-2 (Bcl-2) and proapoptotic Bcl-2-associated X protein (Bax) were evaluated by real-time PCR. Furthermore, caspase-3 protein expression was evaluated by immunohistochemistry. MC administration resulted in a significant reduction in blood glucose and HbA1c and marked elevation of serum levels of insulin, TST, and gonadotropins in diabetic rats. It induced a significant recovery of testicular antioxidant enzymes, improved histopathological changes of the testes, and decreased spermatogenic and Sertoli cell apoptosis. MC effectively inhibited testicular apoptosis, as evidenced by upregulation of Bcl-2 and downregulation of Bax and caspase-3. Moreover, reduction in apoptotic potential in MC-treated groups was confirmed by reduction in the Bax/Bcl-2 mRNA expression ratio.


2004 ◽  
Vol 68 (8) ◽  
pp. 1640-1648 ◽  
Author(s):  
Ozlem OZSOY-SACAN ◽  
Omür KARABULUT-BULAN ◽  
Sehnaz BOLKENT ◽  
Refiye YANARDAG ◽  
Yasemin OZGEY

2016 ◽  
Vol 31 (6) ◽  
pp. 417-421 ◽  
Author(s):  
Mohammad Ashrafzadeh Takhtfooladi ◽  
Ahmad Asghari ◽  
Hesam aldin Hoseinzadeh ◽  
Farahnaz Mokhtari

1999 ◽  
Vol 13 (2) ◽  
pp. 138-141 ◽  
Author(s):  
T. Tunali ◽  
A. Yarat ◽  
R. Yanardagˇ ◽  
F. Özçelik ◽  
Ö. Özsoy ◽  
...  

2006 ◽  
Vol 104 (1-2) ◽  
pp. 175-181 ◽  
Author(s):  
Ozlem Ozsoy-Sacan ◽  
Refiye Yanardag ◽  
Haci Orak ◽  
Yasemin Ozgey ◽  
Aysen Yarat ◽  
...  

Author(s):  
Jitrawadee Intirach ◽  
Anuluck Junkum ◽  
Nongkran Lumjuan ◽  
Udom Chaithong ◽  
Pradya Somboon ◽  
...  

As part of the ongoing screening research for local edible plants in Thailand, Petroselinum crispum fruit oil was considered as a potential bioinsecticide with proven antimosquito activity against both the pyrethroid susceptible and resistant strains of Aedes aegypti. Due to the comparative mosquitocidal efficacy on these mosquitoes, this plant oil is promoted as a natural alternative and attractive candidate for further study in monitoring resistance of mosquito vectors. Therefore, the aim of this study was to evaluate the impact of P. crispum oil on the biochemical characteristics of the target mosquito larvae of Ae. aegypti, by determining quantitative changes of key enzymes responsible for xenobiotic detoxification, including glutathione-S-transferases (GSTs), α- and β-esterases (α-/β-ESTs), acetylcholinesterase (AChE), acid and alkaline phosphatases (ACP and ALP) and mixed-function oxidases (MFO). Three populations of Ae. aegypti, comprising the pyrethroid susceptible Muang Chiang Mai-susceptible (MCM-S) strain and the pyrethroid resistant Pang Mai Dang-resistant (PMD-R) and Upakut-resistant (UPK-R) strains, were used as test organisms. Biochemical study of Ae. aegypti larvae prior to treatment with P. crispum oil revealed that apart from AChE, the baseline activity of most defensive enzymes, such as GSTs, α-/β-ESTs, ACP, ALP and MFO, in resistant UPK-R or PMD-R, was higher than that determined in susceptible MCM-S. However, after 24-h exposure to P. crispum oil, the pyrethroid susceptible and resistant Ae. aegypti showed similarity in biochemical features, with alterations of enzyme activity in the treated larvae, as compared to the controls. A significant increase in the activity levels of GSTs, α-/β-ESTs, ACP and ALP was recorded in all strains of P. crispum oil-treated Ae. aegypti larvae, whereas MFO and AChE activity in these mosquitoes was decreased. The recognizable larvicidal capability on pyrethroid resistant Ae. aegypti, and the inhibitory effect on AChE and MFO, emphasized the potential of P. crispum oil as an attractive alternative application for management of mosquito resistance in current and future control programs.


2003 ◽  
Vol 58 (3) ◽  
pp. 1-7 ◽  
Author(s):  
Göksel Sener ◽  
Özlem Saçan ◽  
Refiye Yanardag ◽  
Gül Ayanoglu-Dülger

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