The Phytoestrogenic Compound Cajanol from Pigeonpea Roots is Associated with the Activation of Estrogen Receptor α-dependent Signaling Pathway in Human Prostate Cancer Cells

2013 ◽  
Vol 27 (12) ◽  
pp. 1834-1841
Author(s):  
Lu Liang ◽  
Chang Gao ◽  
Meng Luo ◽  
Chunjian Zhao ◽  
Wei Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Estrogen Receptor Α ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Dependent Signaling Pathway

scholarly journals PMS1077 Sensitizes TNF-α Induced Apoptosis in Human Prostate Cancer Cells by Blocking NF-κB Signaling Pathway

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61132 ◽  
Author(s):  
Jie Shi ◽  
Jing Chen ◽  
Nawal Serradji ◽  
Ximing Xu ◽  
Heng Zhou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Tnf Α ◽  
Induced Apoptosis

Crude extract ofEuphorbia formosanainduces apoptosis of DU145 human prostate cancer cells acts through the caspase-dependent and independent signaling pathway

2015 ◽  
Vol 31 (11) ◽  
pp. 1600-1611 ◽  
Author(s):  
Jiun-Long Yang ◽  
Jin-Cherng Lien ◽  
Ya-Yin Chen ◽  
Shu-Chun Hsu ◽  
Shu-Jen Chang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Crude Extract ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals TIPE2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Prostate Cancer Cells by Inhibiting PI3K/Akt Signaling Pathway

2016 ◽  
Vol 24 (5) ◽  
pp. 305-313 ◽  
Author(s):  
Qiang Lu ◽  
Zhe Liu ◽  
Zhuo Li ◽  
Jia Chen ◽  
Zhi Liao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Human Prostate ◽  
Migration And Invasion ◽  
Human Prostate Cancer ◽  
Akt Signaling Pathway ◽  
Prostate Cancer Cells

Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TNFAIP8L2, TIPE2) is involved in the invasion and metastasis of human tumors. However, the functional role of TIPE2 in prostate cancer remains unclear. In the present study, we explored the role of TIPE2 in prostate cancer and cancer progression including the molecular mechanism that drives TIPE2-mediated oncogenesis. Our results showed that TIPE2 was lowly expressed in human prostate cancer tissues and cell lines. In addition, restored TIPE2 obviously inhibits proliferation in prostate cancer cells. TIPE2 overexpression also suppresses the epithelial‐mesenchymal transition (EMT) process and migration/invasion in prostate cancer cells. Mechanistically, TIPE2 overexpression obviously inhibits the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K) and Akt in prostate cancer cells. In conclusion, for the first time we demonstrated that TIPE2 overexpression may suppress proliferation, migration, and invasion in prostate cancer cells by inhibiting the PI3K/Akt signaling pathway. Therefore, TIPE2 might serve as a potential therapeutic target for human prostate cancer.

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