Acute, Reproductive Toxicity and Two-generation Teratology Studies of a Standardized Quassinoid-rich Extract ofEurycoma longifoliaJack in Sprague-Dawley Rats

2013 ◽  
Vol 28 (7) ◽  
pp. 1022-1029 ◽  
Author(s):  
Bin-Seng Low ◽  
Prashanta Kumar Das ◽  
Kit-Lam Chan
Keyword(s):  
Reproductive Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

The reproductive toxicity of organic compounds extracted from drinking water sources on Sprague Dawley rats: An in vitro study

2009 ◽  
Vol 25 (3) ◽  
pp. 284-293 ◽  
Author(s):  
Jiang Wu ◽  
Guanjiu Hu ◽  
Xiaoyi Wang ◽  
Dongmei Li ◽  
Hongxia Yu ◽  
...  
Keyword(s):  
Drinking Water ◽  
Organic Compounds ◽  
Reproductive Toxicity ◽  
In Vitro Study ◽  
Water Sources ◽  
Vitro Study ◽  
Sprague Dawley ◽  
Drinking Water Sources ◽  
Sprague Dawley Rats

REPRODUCTIVE TOXICITY SCREEN OF TRIFLUOROIODOMETHANE (CF3I) IN SPRAGUE-DAWLEY RATS

1999 ◽  
Vol 11 (11) ◽  
pp. 1041-1055 ◽  
Author(s):  
D.E. Dodd ◽  
H.F. Leahy ◽  
M.L. Feldmann ◽  
J.H. English ◽  
A. Vinegar
Keyword(s):  
Reproductive Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

One-generation reproductive toxicity study of epichlorohydrin in Sprague-Dawley rats

2010 ◽  
Vol 33 (3) ◽  
pp. 291-301 ◽  
Author(s):  
In-Sik Shin ◽  
Na-Hyeong Park ◽  
Jong-Chan Lee ◽  
Kang-Hyeon Kim ◽  
Changjong Moon ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effects of short-term administration of .ALPHA.-chlorohydrin on reproductive toxicity parameters in male Sprague-Dawley rats.

1995 ◽  
Vol 20 (3) ◽  
pp. 195-205 ◽  
Author(s):  
Takashi YAMADA ◽  
Tadahiro INOUE ◽  
Akinori SATO ◽  
Kumiko YAMAGISHI ◽  
Motonobu SATO
Keyword(s):  
Reproductive Toxicity ◽  
Sprague Dawley ◽  
Short Term ◽  
Sprague Dawley Rats ◽  
Term Administration

scholarly journals A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats

2019 ◽  
Vol 84 ◽  
pp. 75-92
Author(s):  
F. Jay Murray ◽  
Frank M. Sullivan ◽  
Sue A. Hubbard ◽  
Alan M. Hoberman ◽  
Sandra Carey
Keyword(s):  
Drinking Water ◽  
Reproductive Toxicity ◽  
Sodium Molybdate ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

2020 ◽  
Vol 39 (8) ◽  
pp. 1079-1094 ◽  
Author(s):  
H Rehman ◽  
S Jahan ◽  
I Ullah ◽  
P-O Thörnqvist ◽  
M Jabbar ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Head Tilt ◽  
Treated Group ◽  
Toxicity Study ◽  
Female Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Estrous Cyclicity ◽  
F1 Generation

The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg−1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg−1 and 10 mg kg−1), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg−1. Number of live pups at birth were decreased ( p < 0.001) at 10 mg kg−1. At postnatal day (PND) 70, a significant ( p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats ( p = 0.05) was observed in 10 mg kg−1 furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg−1), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production ( p = 0.01) and disturbed estrous cyclicity ( p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg−1 bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.

Sign in / Sign up

Export Citation Format

Share Document