Traditional Oriental Herbal Medicine and Natural Killer Cells for Cancer Patients: A Systematic Review and Meta-analysis

2017 ◽  
Vol 31 (4) ◽  
pp. 519-532 ◽  
Author(s):  
Kyeore Bae ◽  
Ji-hye Park ◽  
Jeehye Kim ◽  
Chong-kwan Cho ◽  
Byeongsang Oh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Killer Cells ◽  
Herbal Medicine ◽  
Natural Killer ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Killer Cells

scholarly journals Outcomes with Natural Killer Cells Infusion after Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 1847-1847
Author(s):  
Muhammad Umair Mushtaq ◽  
Moazzam Shahzad ◽  
Amna Y Shah ◽  
Muhammad Usman Zafar ◽  
Ezza Tariq ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Research Funding ◽  
Meta Analysis ◽  
Killer Cells ◽  
Hematopoietic Stem ◽  
Relapsed Disease

Abstract Background: Natural killer cells (NK) are known to be the first cells that recover after allogeneic hematopoietic stem cell transplant (HCT). NK cells have anti-leukemic and anti-viral properties and are also implicated in the graft versus leukemia (GVL) effect without causing graft versus host disease (GVHD). There is emerging evidence supporting the use of NK cells post-transplant as adoptive immunotherapy to prevent or treat the relapse of hematologic malignancies. Here, we present a systematic review and meta-analysis aimed to investigate the outcomes with NK cells infusion after HCT. Methods: A detailed literature search was conducted for the systematic review and meta-analysis according to the guidelines mentioned in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Population, intervention, comparison, and outcome (PICO) table was developed and three electronic databases (PubMed, Cochrane Library, and ClinicalTrials.gov) were searched through January 2021 using MeSH terms and keywords for "hematologic malignancy and natural killer cells" and "hematopoietic stem cell transplantation and natural killer cells". No filters or publication time limits were applied for the search. A total of 988 records were identified through database searching. After excluding duplicates, review, and non-relevant articles, we selected 9 studies that reported outcomes with NK cells infusion after HCT. Quality evaluation was done using the NIH quality assessment tool and Inter-study variance was calculated using the Der Simonian-Laird Estimator. Pooled analysis was done using the 'meta' package (Schwarzer et al, R programming language) and proportions with 95% confidence intervals (CI) were computed. Results: We identified 9 studies with a total of 149 participants. Out of these, 53 patients were from 4 studies using NK cells for the treatment of relapsed disease after HCT (therapeutic studies) and 96 patients were from 5 studies using NK cells to prevent relapse after HCT (pre-emptive studies). Therapeutic use of NK cells for relapsed disease after HCT: A total of 53 patients from 4 studies were evaluated. The median age of patients was 44.5 (1.9-69) years, and 40% patients were male. The median follow-up was 20 (1-69) months. Overall survival (OS) was reported by two studies at 2 years and was 36.3% and 55%. The pooled complete response (CR) was 18% (95% CI 0.06-0.33, I 2 =0%, n=37) and overall response rate (ORR) was 45% (95% CI 0.20-0.71, I 2 =71%, n=53). The pooled relapse rate was 65% (95% CI 0.32-0.92, I 2 =75%, n=42). The pooled incidence of acute GVHD and chronic GVHD was 15% (95% CI 0.03-0.31, I 2 =41%, n=53) and 8% (95% CI 0.01-0.18, I 2 =0%, n=53) respectively. Pre-emptive use of NK cells to prevent relapse after HCT: A total of 96 patients from 5 studies were evaluated. The median age of patients was 33.5 (2-75) years, and 48% patients were males. The median follow-up was 23.1 (8-81.6) months. The median OS was 1 (0.63-5) years. The pooled CR was 45% (95% CI 0.21-0.70, I 2 =76%, n=83) and ORR was 89% (95% CI 0.57-1.00, I 2 =77%, n=42). The pooled relapse rate was 35% (95% CI 0.20-0.52, I 2 =55%, n=96). The pooled incidence of acute GVHD and chronic GVHD was 30% (95%CI 0.14-0.48, I 2 =61%, n=96) and 8% (95%CI 0.00-0.24, I 2 =73%, n=96) respectively. Conclusion: Infusion of NK cells after HCT to prevent relapsed disease results in favorable outcomes with an acceptable toxicity profile. Optimal use of NK cells infusions after HCT is in a pre-emptive fashion to prevent relapsed disease and the efficacy of NK cells infusions after HCT in the setting of overt hematologic relapse is modest. Our findings suggest the need for large prospective clinical trials to establish the potential benefit of NK cells infusion after HCT to prevent relapse of hematologic malignancies without increased non-relapse mortality. Figure 1 Figure 1. Disclosures Abhyankar: Incyte/Therakos: Consultancy, Research Funding, Speakers Bureau. McGuirk: Bellicum Pharmaceuticals: Research Funding; Gamida Cell: Research Funding; Novartis: Research Funding; Novartis: Research Funding; EcoR1 Capital: Consultancy; Fresenius Biotech: Research Funding; Astelllas Pharma: Research Funding; Magenta Therapeutics: Consultancy, Honoraria, Research Funding; Juno Therapeutics: Consultancy, Honoraria, Research Funding; Allovir: Consultancy, Honoraria, Research Funding; Pluristem Therapeutics: Research Funding; Kite/ Gilead: Consultancy, Honoraria, Other: travel accommodations, expense, Kite a Gilead company, Research Funding, Speakers Bureau.

scholarly journals Altered Immune Profiles of Natural Killer Cells in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160171 ◽  
Author(s):  
Qiong-Fang Zhang ◽  
Jian-Ying Shao ◽  
Wen-Wei Yin ◽  
Yang Xia ◽  
Ling Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Hepatitis ◽  
Natural Killer Cells ◽  
Hepatitis B ◽  
Natural Killer ◽  
Chronic Hepatitis B ◽  
Meta Analysis ◽  
Killer Cells

scholarly journals Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 10 ◽  
Author(s):  
Sha Li ◽  
Tsz-him So ◽  
Guoyi Tang ◽  
Hor-Yue Tan ◽  
Ning Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Side Effects ◽  
Herbal Medicine ◽  
Cancer Patients ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Chemotherapeutic Agents ◽  
Breast Cancer Patients ◽  
Chinese Herbal

BackgroundChemotherapy usually induces a variety of side-effects in cancer treatment as it cannot tell normal cells apart from cancer cells and kills both. Chinese herbal medicine (CHM) has been regarded as a potential effective intervention for relieving the side-effects of chemotherapy in breast cancer patients.ObjectiveThis study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the efficacy of CHM as adjuvant therapy for reducing the chemotherapy-induced side-effects in the treatment of breast cancer.MethodsMain electronic databases were searched up to May 2020 for Randomized Controlled Trials (RCTs) evaluating the effect of CHM on breast cancer patients with chemotherapy. The PRISMA statement was adopted in this study and meta-analyses were performed.ResultsThe included studies showed unsatisfied quality. Results based on available literature indicated that the adjunctive use of CHM with chemotherapy may reduce the chemotherapeutic agents-associated adverse events, including nausea and vomiting, diarrhea, alopecia, myelosuppression, and impaired immune function.ConclusionA confident conclusion could not be have due to the lack of large scale and high quality trials.

scholarly journals Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients

2019 ◽  
Vol 27 (6) ◽  
pp. 1114-1125 ◽  
Author(s):  
Lin Xiao ◽  
Dongzhi Cen ◽  
Haining Gan ◽  
Yan Sun ◽  
Nanqi Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Cancer Patients ◽  
Adoptive Transfer ◽  
Killer Cells ◽  
Colorectal Cancer Patients

scholarly journals Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125)

Immunology ◽  
2007 ◽  
Vol 122 (3) ◽  
pp. 418-429 ◽  
Author(s):  
Jennifer A. Belisle ◽  
Jennifer A. A. Gubbels ◽  
Cara A. Raphael ◽  
Martine Migneault ◽  
Claudine Rancourt ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Natural Killer Cells ◽  
Epithelial Ovarian Cancer ◽  
Natural Killer ◽  
Cancer Patients ◽  
Tumour Marker ◽  
Killer Cells
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