Hormonal contraceptive use associated with increased risk of suicidal behavior

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use >10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.

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Oral contraceptive use and risk of suicidal behavior among young women

Psychological Medicine ◽

10.1017/s0033291720003475 ◽

2020 ◽

pp. 1-8

Author(s):

Alexis C. Edwards ◽

Sara Larsson Lönn ◽

Casey Crump ◽

Eve K. Mościcki ◽

Jan Sundquist ◽

...

Keyword(s):

Oral Contraceptive ◽

Oral Contraceptives ◽

Young Women ◽

Suicidal Behavior ◽

Contraceptive Use ◽

Cox Proportional Hazards ◽

Causal Mechanism ◽

Parental History ◽

Oral Contraceptive Use ◽

Increased Risk

Abstract Background Oral contraceptive use has been previously associated with an increased risk of suicidal behavior in some, but not all, samples. The use of large, representative, longitudinally-assessed samples may clarify the nature of this potential association. Methods We used Swedish national registries to identify women born between 1991 and 1995 (N = 216 702) and determine whether they retrieved prescriptions for oral contraceptives. We used Cox proportional hazards models to test the association between contraceptive use and first observed suicidal event (suicide attempt or death) from age 15 until the end of follow-up in 2014 (maximum age 22.4). We adjusted for covariates, including mental illness and parental history of suicide. Results In a crude model, use of combination or progestin-only oral contraceptives was positively associated with suicidal behavior, with hazard ratios (HRs) of 1.73–2.78 after 1 month of use, and 1.25–1.82 after 1 year of use. Accounting for sociodemographic, parental, and psychiatric variables attenuated these associations, and risks declined with increasing duration of use: adjusted HRs ranged from 1.56 to 2.13 1 month beyond the initiation of use, and from 1.19 to 1.48 1 year after initiation of use. HRs were higher among women who ceased use during the observation period. Conclusions Young women using oral contraceptives may be at increased risk of suicidal behavior, but risk declines with increased duration of use. Analysis of former users suggests that women susceptible to depression/anxiety are more likely to cease hormonal contraceptive use. Additional studies are necessary to determine whether the observed association is attributable to a causal mechanism.

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Risk of meningioma associated with exposure of hormonal contraception. A case control study

Majalah Obstetri & Ginekologi ◽

10.20473/mog.v1i12018.36-41 ◽

2018 ◽

Vol 26 (1) ◽

pp. 36

Author(s):

Joni Wahyuhadi ◽

Dini Heryani ◽

Hari Basuki Basuki

Keyword(s):

Contraceptive Use ◽

Case Control Study ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Case Control ◽

Control Group ◽

Contraceptive Pills ◽

Increased Risk ◽

History Of ◽

Control Study

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use >10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.

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Influence of hormonal contraceptives and the occurrence of stroke: integrative review

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2016-0056 ◽

2017 ◽

Vol 70 (3) ◽

pp. 647-655 ◽

Cited By ~ 6

Author(s):

Adman Câmara Soares Lima ◽

Larissa Castelo Guedes Martins ◽

Marcos Venícios de Oliveira Lopes ◽

Thelma Leite de Araújo ◽

Francisca Elisângela Teixeira Lima ◽

...

Keyword(s):

Contraceptive Use ◽

Sedentary Lifestyle ◽

Scientific Evidence ◽

Hormonal Contraceptive ◽

Integrative Review ◽

Hormonal Contraceptives ◽

Contraceptive Agents ◽

Contraceptive Devices ◽

Increased Risk ◽

Different Types

ABSTRACT Objective: To identify scientific evidence regarding the influence of hormonal contraceptive use and the occurrence of stroke. Method: Integrative review of the literature, through database search using the descriptors "contraceptive agents", "contraceptive devices", "contraceptives, Oral" and "Stroke". Original studies in Portuguese, Spanish and English, published in full and available online were included. Studies that did not answer our guiding questions and duplicated studies were excluded. Results: Women using combined oral contraceptives have higher risk of stroke, even with a lower hormonal dosage and different types of progestogen, regardless of the duration of use. The use of contraceptives associated with smoking, hypertension, migraine, hypercholesterolemia, obesity and sedentary lifestyle increases the chance of stroke. Contraceptive patch and vaginal ring are associated to increased risk. Conclusion: Use of combined hormonal contraceptives, except for the injectable and the transdermal ones, increases the chance of occurrence of the event. Progestogen-only contraceptives were considered safe.

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Relationship between Metabolic Syndrome and History of Cervical Cancer among a US National Population

ISRN Oncology ◽

10.1155/2013/840964 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Eribeth K. Penaranda ◽

Navkiran Shokar ◽

Melchor Ortiz

Keyword(s):

Metabolic Syndrome ◽

Cervical Cancer ◽

Contraceptive Use ◽

Hormonal Contraceptive ◽

Cervical Cancer Risk ◽

Colon Cancers ◽

The Metabolic Syndrome ◽

Increased Risk ◽

History Of ◽

Using Data

The metabolic changes present in the metabolic syndrome (MetS) have been associated with increased risk of pancreatic and colon cancers; however, there is little information about the association between MetS and cervical cancer risk. We performed a case-control study using data from the National Health and Nutrition Examination Survey (NHANES) between 1999–2010. We identified women 21 years of age and older, of which an estimated 585,924 (2.3% of the sample) self-reported a history of cervical cancer (cases). About half (48.6%) of cases and 33.2% of controls met criteria for MetS. Logistic regression analysis showed increased odds of history of cervical cancer among women with MetS (OR=1.9; 95% CI 1.06, 3.42; P value ≤ 0.05) for the risk of history of cervical cancer among women with MetS while adjusting for other known risk factors (high number of lifetime sexual partners, multiparty, history of hormonal contraceptive use, and history of smoking) (AOR=1.82; 95% CI 1.02, 3.26; P value ≤ 0.05). In this US surveyed population we found increased odds of history of cervical cancer among subjects with MetS.

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The Effects of Ovulatory Cycle Phase and Hormonal Contraceptive Use on Changes in Perceived Exertion and Pain During Exercise

PsycEXTRA Dataset ◽

10.1037/e741342011-077 ◽

2009 ◽

Author(s):

Ann Caldwell ◽

Angela Bryan ◽

Melissa Heap

Keyword(s):

Perceived Exertion ◽

Contraceptive Use ◽

Hormonal Contraceptive ◽

Cycle Phase ◽

Ovulatory Cycle

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ECTOPIC PREGNANCY WITH ACCEPTOR IMPLANT

JOURNAL OBGIN EMAS ◽

10.25077/aogj.3.1.48-55.2019 ◽

2019 ◽

Vol 3 (1) ◽

pp. 48-55

Author(s):

Putri Zelfitri Zen ◽

Yusrawati Yusrawati

Keyword(s):

Ectopic Pregnancy ◽

Contraceptive Use ◽

Abdominal Cavity ◽

Uterine Cavity ◽

Hormonal Contraceptive ◽

Obstetrics And Gynecology

Objective: To report a case of Ectopic pregnancy with implant receptorsMaterials and Methods: This article describes the case of a 41-year-old woman, diagnosed with an Ectopic Pregnancy on the gravid G5P4A0H4 11-12 weeks. Patients are using implant contraception, which has been used since 2009-2018 (3 installations). The patient came to the obstetrics and gynecology clinic Dr. M. Djamil Padang. The ultrasound gives the impression of Ectopic pregnancy in the infindibule tube. Analysis Ectopic pregnancy can also occur due to the influence of hormonal contraceptive use (progesterone).Results: Patient gets intervention performed laparotomy After the peritoneum is opened it appears fresh red blood amounting to ± 500 cc filling the abdominal cavity. Blood evacuation and exploration are performed, it appears that the source of bleeding originates from the left tubal rupture (Infundibulum) Impression of the left tubal rupture (Infundibulum) ecectic ectopic pregnancy is impaired. Sinistal salpingectomy is performed.Conclusion: Ectopic pregnancy Ectopic pregnancy is all pregnancies where the ovum fertilized by spermatozoa implant and grows outside the uterine cavity endometrial.

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