Surface‐Acoustic‐Wave‐Based Lab‐on‐Chip for Rapid Transport of Cryoprotectants across Cell Membrane for Cryopreservation with Significantly Improved Cell Viability

Droplet streaming and nebulization on a shear horizontal surface acoustic wave device made of 36o Y-cut LiTaO3 have been reported. The streaming pattern inside the droplet is sensitive to the droplet shape, the position to the interdigital transducer, and the aperture size. Droplet nebulization was enhanced with the increased aperture size of the driven IDTs and mainly occurred in horizontal direction along two lateral sides of the droplet, which is perpendicular to the designed SAW propagation direction. The atomization duration increases with the droplet size and decreases with the driven power at a given droplet size. The maximum rate of the atomization is ~0.2 μL/s at an applied power of 6.7 W. This provides a simple and effective method of the integration of both bio-liquid sensing and fluid manipulation on a single substrate for lab-on-chip biosensing platform.

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Theoretical Analysis and Experimental Verification on High-Isolation Surface-Acoustic-Wave Duplexer with On-Chip Compensation Circuit

IEICE Transactions on Electronics ◽

10.1587/transele.2018ecp5075 ◽

2019 ◽

Vol E102.C (10) ◽

pp. 748-755

Author(s):

Masafumi IWAKI ◽

Masanori UEDA ◽

Yoshio SATOH

Keyword(s):

Theoretical Analysis ◽

Acoustic Wave ◽

Surface Acoustic Wave ◽

Experimental Verification ◽

Compensation Circuit ◽

High Isolation ◽

On Chip

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On-chip cell mechanophenotyping using phase modulated surface acoustic wave

Biomicrofluidics ◽

10.1063/1.5084297 ◽

2019 ◽

Vol 13 (2) ◽

pp. 024107 ◽

Cited By ~ 3

Author(s):

Yanqi Wu ◽

Alastair G. Stewart ◽

Peter V. S. Lee

Keyword(s):

Acoustic Wave ◽

Surface Acoustic Wave ◽

On Chip

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Combining Mass Spectrometry, Surface Acoustic Wave Interaction Analysis, and Cell Viability Assays for Characterization of Shiga Toxin Subtypes of PathogenicEscherichia coliBacteria

Analytical Chemistry ◽

10.1021/acs.analchem.8b01189 ◽

2018 ◽

Vol 90 (15) ◽

pp. 8989-8997 ◽

Cited By ~ 8

Author(s):

Daniel Steil ◽

Gottfried Pohlentz ◽

Nadine Legros ◽

Michael Mormann ◽

Alexander Mellmann ◽

...

Keyword(s):

Mass Spectrometry ◽

Acoustic Wave ◽

Cell Viability ◽

Surface Acoustic Wave ◽

Shiga Toxin ◽

Interaction Analysis ◽

Wave Interaction

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Flexible Surface Acoustic Wave Device with AlN Film on Polymer Substrate

Journal of Control Science and Engineering ◽

10.1155/2012/610160 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Jian Zhou ◽

Shurong Dong ◽

Hao Jin ◽

Bing Feng ◽

Demiao Wang

Keyword(s):

Acoustic Wave ◽

Surface Acoustic Wave ◽

Polymer Substrates ◽

Lab On Chip ◽

Flexible Surface ◽

Aln Film ◽

Surface Acoustic Wave Device ◽

Acoustic Wave Devices ◽

Acoustic Wave Device ◽

Wave Device

Surface acoustic wave device withc-axis-oriented aluminum nitride (AlN) piezoelectric thin films on polymer substrates can be potentially used for development of flexible sensors, flexible microfluidic applications, microsystems, and lab-on-chip systems. In this work, the AlN films have been successfully deposited on polymer substrates using the DC reactive magnetron-sputtering method at room temperature, and the XRD, SEM, and AFM methods reveal that low deposition pressure is beneficial to the highlyc-axis-oriented AlN film on polymer substrates. Studies toward the development of AlN thin film-based flexible surface acoustic wave devices on the polymer substrates are initiated and the experimental and simulated results demonstrate the devices showing the acoustic wave velocity of 9000–10000 m/s, which indicate the AlN lamb wave.

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