scholarly journals Steerable Microinvasive Probes for Localized Drug Delivery to Deep Tissue

Small ◽  
2019 ◽  
Vol 15 (37) ◽  
pp. 1901459 ◽  
Author(s):  
Max J. Cotler ◽  
Erin B. Rousseau ◽  
Khalil B. Ramadi ◽  
Joshua Fang ◽  
Ann M. Graybiel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Deep Tissue ◽  
Localized Drug Delivery

Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants

2020 ◽  
Vol 27 (6) ◽  
pp. 854-902 ◽  
Author(s):  
Raluca Ion ◽  
Madalina Georgiana Necula ◽  
Anca Mazare ◽  
Valentina Mitran ◽  
Patricia Neacsu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tio2 Nanotubes ◽  
Therapeutic Agent ◽  
Bone Defects ◽  
Delivery Systems ◽  
Antimicrobial Compounds ◽  
Bone Implant ◽  
Bioactive Agents ◽  
Localized Drug Delivery ◽  
Regeneration Of Bone

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.

scholarly journals Smart Packaging: A Novel Technique For Localized Drug Delivery

2009 ◽  
Vol 96 (3) ◽  
pp. 687a ◽  
Author(s):  
Eva Christabel Williams ◽  
Ryan Toomey ◽  
Norma Alcantar
Keyword(s):  
Drug Delivery ◽  
Smart Packaging ◽  
Novel Technique ◽  
Localized Drug Delivery

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

scholarly journals Biopolymer Hydrogel Scaffolds Containing Doxorubicin as A Localized Drug Delivery System for Inhibiting Lung Cancer Cell Proliferation

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3580
Author(s):  
Chuda Chittasupho ◽  
Jakrapong Angklomklew ◽  
Thanu Thongnopkoon ◽  
Wongwit Senavongse ◽  
Pensak Jantrawut ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Encapsulation Efficiency ◽  
Lung Cancer Cell ◽  
Hydrogel Scaffold ◽  
Hydrogel Scaffolds ◽  
Localized Drug Delivery

A hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy. The encapsulation efficiency and the release profile of doxorubicin from the hydrogel scaffolds were determined using UV-Vis spectrophotometry. The anti-proliferative effect of the scaffolds against the lung cancer cell line was investigated using an MTT assay. The results showed that scaffolds made from different types of natural polymer had different pore configurations and pore sizes. All scaffolds had high encapsulation efficiency and drug-controlled release profiles. The viability and proliferation of A549 cells, treated with gelatin, gelatin/SCMC, and SCMC scaffolds containing doxorubicin significantly decreased compared with control. These hydrogel scaffolds might provide a promising approach for developing a superior localized drug delivery system to kill lung cancer cells.

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery: Rheological Properties andin vivoDegradation

2009 ◽  
Vol 9 (8) ◽  
pp. 786-794 ◽  
Author(s):  
Laurianne Timbart ◽  
M. Yat Tse ◽  
Stephen C. Pang ◽  
Oladunni Babasola ◽  
Brian G. Amsden
Keyword(s):  
Drug Delivery ◽  
Rheological Properties ◽  
Trimethylene Carbonate ◽  
Low Viscosity ◽  
Localized Drug Delivery

Sustained Localized Drug Delivery In Mammalian Lung By Bronchoscopy

2012 ◽  
Author(s):  
George Horng ◽  
Syed Askari ◽  
Yeon Choi ◽  
Warren Grundfest
Keyword(s):  
Drug Delivery ◽  
Mammalian Lung ◽  
Localized Drug Delivery
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