Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery: Rheological Properties andin vivoDegradation

2009 ◽  
Vol 9 (8) ◽  
pp. 786-794 ◽  
Author(s):  
Laurianne Timbart ◽  
M. Yat Tse ◽  
Stephen C. Pang ◽  
Oladunni Babasola ◽  
Brian G. Amsden
2020 ◽  
Vol 27 (6) ◽  
pp. 854-902 ◽  
Author(s):  
Raluca Ion ◽  
Madalina Georgiana Necula ◽  
Anca Mazare ◽  
Valentina Mitran ◽  
Patricia Neacsu ◽  
...  

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.


Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 681
Author(s):  
Monika Sterczyńska ◽  
Marek Zdaniewicz ◽  
Katarzyna Wolny-Koładka

During the production of beer, and especially beer wort, the main wastes are spent grain and hot trub, i.e., the so-called “hot break.” Combined with yeast after fermentation, they represent the most valuable wastes. Hot trub is also one of the most valuable by-products. Studies on the chemical composition of these sediments and their rheological properties as waste products will contribute to their effective disposal and even further use as valuable pharmaceutical and cosmetic raw materials. So far, hot trub has been studied for morphology and particle distribution depending on the raw material composition and beer wort extract. However, there are no preliminary studies on the rheological properties of hot trub and hops. In particular, no attention has yet been paid to the dependence of these properties on the hop variety or different protein sources used. The aim of this study was to examine the effect of different hopping methods on hot trub viscosity and beer wort physicochemical parameters. Additionally, the hop solutions were measured at different temperatures. A microbiological analysis of hop sediments was also performed to determine the post-process survival of selected microorganisms in these wastes. For manufacturers of pumps used in the brewing industry, the most convenient material is that of the lowest viscosity. Low viscosity hot trub can be removed at lower velocities, which reduces costs and simplifies washing and transport. The sediments also had similar equilibrium viscosity values at high shear rates.


2020 ◽  
pp. 095400832098343
Author(s):  
Xiaomu Wen ◽  
Ximing Zhang ◽  
Keke Chen ◽  
Yunjun Luo

Both better mechanical and rheological properties are pursued for composite solid propellant. In this work, varying proportions of a modified hyperbranched polyester (MHBPE) were added to HTPE/AP/Al propellant. The static tensile property as one kind of mechanical properties of MHBPE/HTPE/AP/Al propellant were found to be superior to those of blank HTPE/AP/Al propellant as a result of the entanglement and interpenetration of molecular chains caused by the introduction of the hyperbranched structure. Evaluations on the related improved creep resistance and stress relaxation performance further demonstrated the advantages of introduction of MHBPE to HTPE/AP/Al propellant. Rheological properties of HTPE/AP/Al propellant with and without MHBPE during the casting process were investigated and compared and the results confirmed the improvement benefiting from low viscosity and loose void structure. Thus, modified hyperbranched polyester provided a novel route to potentially meet the requirements for propellant manufacturing and applications.


Biomaterials ◽  
2021 ◽  
pp. 120919
Author(s):  
Christopher C. Parkins ◽  
Joseph H. McAbee ◽  
Lisa Ruff ◽  
Astrid Wendler ◽  
Richard Mair ◽  
...  

2009 ◽  
Vol 96 (3) ◽  
pp. 687a ◽  
Author(s):  
Eva Christabel Williams ◽  
Ryan Toomey ◽  
Norma Alcantar

e-Polymers ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Liang Chen ◽  
Peng He ◽  
Zhifeng Jia ◽  
Xinyuan Zhu ◽  
Deyue Yan

AbstractAn economical strategy to prepare hyperbranched poly(sulfone-amine) modified β-cyclodextrins (HPSA-m-CDs) from natural β-cyclodextrin (β-CD) and other commercially available materials has been reported. The final product has many good properties of hyperbranched poly(sulfone-amine)s (good solubility, low viscosity etc.), while its inclusion ability can also be well kept. It is a feasible approach to prepare functionalized modified cyclodextrin at very low cost, and may have potential applications in the fields of catalysis, drug delivery, food additives, etc.


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