Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants

2020 ◽  
Vol 27 (6) ◽  
pp. 854-902 ◽  
Author(s):  
Raluca Ion ◽  
Madalina Georgiana Necula ◽  
Anca Mazare ◽  
Valentina Mitran ◽  
Patricia Neacsu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tio2 Nanotubes ◽  
Therapeutic Agent ◽  
Bone Defects ◽  
Delivery Systems ◽  
Antimicrobial Compounds ◽  
Bone Implant ◽  
Bioactive Agents ◽  
Localized Drug Delivery ◽  
Regeneration Of Bone

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.

Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

2020 ◽  
Vol 17 (10) ◽  
pp. 911-924
Author(s):  
Rohitas Deshmukh
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Target Tissue ◽  
Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

scholarly journals Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Rongwei Cui ◽  
Qiang Wu ◽  
Jing Wang ◽  
Xiaoming Zheng ◽  
Rongying Ou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery Systems ◽  
Malignant Tumors ◽  
Delivery Systems ◽  
The Past ◽  
Therapeutic Benefits ◽  
Localized Drug Delivery ◽  
Smart Drug ◽  
Smart Drug Delivery

Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.

scholarly journals Current State and Promising Opportunities on Pharmaceutical Approaches in the Treatment of Polymicrobial Diseases

Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 245 ◽  
Author(s):  
Sartini Sartini ◽  
Andi Dian Permana ◽  
Saikat Mitra ◽  
Abu Montakim Tareq ◽  
Emil Salim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Antimicrobial Agents ◽  
Pharmaceutical Formulations ◽  
Delivery Systems ◽  
Antimicrobial Compounds ◽  
Antimicrobial Drugs ◽  
Current State ◽  
Delivery Strategies

In recent years, the emergence of newly identified acute and chronic infectious disorders caused by diverse combinations of pathogens, termed polymicrobial diseases, has had catastrophic consequences for humans. Antimicrobial agents have been clinically proven to be effective in the pharmacological treatment of polymicrobial diseases. Unfortunately, an increasing trend in the emergence of multi-drug-resistant pathogens and limited options for delivery of antimicrobial drugs might seriously impact humans’ efforts to combat polymicrobial diseases in the coming decades. New antimicrobial agents with novel mechanism(s) of action and new pharmaceutical formulations or delivery systems to target infected sites are urgently required. In this review, we discuss the prospective use of novel antimicrobial compounds isolated from natural products to treat polymicrobial infections, mainly via mechanisms related to inhibition of biofilm formation. Drug-delivery systems developed to deliver antimicrobial compounds to both intracellular and extracellular pathogens are discussed. We further discuss the effectiveness of several biofilm-targeted delivery strategies to eliminate polymicrobial biofilms. At the end, we review the applications and promising opportunities for various drug-delivery systems, when compared to conventional antimicrobial therapy, as a pharmacological means to treat polymicrobial diseases.

scholarly journals Erythrocyte as novel cellular drug delivery system

2020 ◽  
Vol 1 (4) ◽  
pp. 151-156
Author(s):  
Subhi SS ◽  
S Thamrook
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Agent ◽  
Degradation Products ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Isolation Techniques ◽  
Novel Approach ◽  
Carrier Systems

Nowadays so many carrier systems are used for delivery of drug or any other therapeutic agent to specific tissues or cells for achieving desired therapeutic efficacy. Using drug delivery systems can improve action of therapeutic agent and reduce their toxicity. As a novel approach the erythrocyte or red blood cells are used for drug delivery. The resealed erythrocyte is a cellular carrier have more advantage than other carrier system. Based on various studies found that erythrocyte have greater potential in delivery of biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biological, antigens, anticancer drug and vaccines. The main problem obtain in case of existing carrier systems are biocompatibility of carrier and its degradation products. The biocompatibility, non-pathogenicity, non-immunogenicity and biodegradability make erythrocyte unique and useful carriers. They also possess longer circulation half-life and zero order drug release kinetics. Resealed erythrocyte carriers have certain impact among the activity of certain therapeutic agent like anti-inflammatory drugs, steroids, chemotherapeutic agents by reducing their side effect upon incorporation with these carriers. The general preparation step of resealed erythrocyte involve separation of erythrocyte from blood the organism of interest and using different methods the erythrocyte broken and the therapeutic agent or drug entrapped into the erythrocyte. This review article highlights the characteristics, isolation techniques of erythrocyte, preparation method, evaluation, application of resealed erythrocyte as carrier in drug delivery systems.

scholarly journals Carrier-free nanoparticles of camptothecin prodrug for chemo-photothermal therapy: the making, in vitro and in vivo testing

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mingtao Ao ◽  
Fei Yu ◽  
Yixiang Li ◽  
Mengya Zhong ◽  
Yonghe Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Photothermal Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Agent ◽  
Delivery Systems ◽  
Amphiphilic Drug ◽  
Carrier Free

Abstract Background Nanoscale drug delivery systems have emerged as broadly applicable approach for chemo-photothermal therapy. However, these nanoscale drug delivery systems suffer from carrier-induced toxicity, uncontrolled drug release and low drug carrying capacity issues. Thus, to develop carrier-free nanoparticles self-assembled from amphiphilic drug molecules, containing photothermal agent and anticancer drug, are very attractive. Results In this study, we conjugated camptothecin (CPT) with a photothermal agent new indocyanine green (IR820) via a redox-responsive disulfide linker. The resulting amphiphilic drug–drug conjugate (IR820-SS-CPT) can self-assemble into nanoparticles (IR820-SS-CPT NPs) in aqueous solution, thus remarkably improving the membrane permeability of IR820 and the aqueous solubility of CPT. The disulfide bond in the IR820-SS-CPT NPs could be cleaved in GSH rich tumor microenvironment, leading to the on demand release of the conjugated drug. Importantly, the IR820-SS-CPT NPs displayed an extremely high therapeutic agent loading efficiency (approaching 100%). Besides, in vitro experimental results indicated that IR820-SS-CPT NPs displayed remarkable tumor cell killing efficiency. Especially, the IR820-SS-CPT NPs exhibited excellent anti-tumor effects in vivo. Both in vitro and in vivo experiments were conducted, which have indicated that the design of IR820-SS-CPT NPs can provide an efficient nanotherapeutics for chemo-photothermal therapy. Conclusion A novel activatable amphiphilic small molecular prodrug IR820-SS-CPT has been developed in this study, which integrated multiple advantages of GSH-triggered drug release, high therapeutic agent content, and combined chemo-photothermal therapy into one drug delivery system. Graphical Abstract

scholarly journals Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 791 ◽  
Author(s):  
Long Binh Vong ◽  
Yukio Nagasaki
Keyword(s):  
Nitric Oxide ◽  
Drug Delivery ◽  
Therapeutic Agent ◽  
Cancer Therapeutics ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
New Drugs ◽  
Therapeutic Drug ◽  
Cancer Treatments ◽  
Specific Distribution

Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects. To overcome the drawbacks of using this gaseous signaling molecule, researchers in the last several decades have focused on innovative medical technologies, specifically nanoparticle-based drug delivery systems (DDSs), because these systems alter the biodistribution of the therapeutic agent through controlled release at the target tissues, resulting in a significant therapeutic drug effect. Thus, the application of nano-systems for NO delivery in the field of biomedicine, particularly in the development of new drugs for cancer treatment, has been increasing worldwide. In this review, we discuss NO delivery nanoparticle systems, with the aim of improving drug delivery development for conventional chemotherapies and controlling multidrug resistance in cancer treatments.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Sign in / Sign up

Export Citation Format

Share Document